Protein Alignment SMC1 and psm1

DIOPT Version :10

• Sequence 1: NP_651211.2
• Gene: SMC1 / 42853
• FlyBaseID: FBgn0040283
• Length: 1238
• Species: Drosophila melanogaster
• Sequence 2: NP_596049.2
• Gene: psm1 / 2540557
• PomBaseID: SPBC29A10.04
• Length: 1228
• Species: Schizosaccharomyces pombe
• Alignment Length: 1267
• Identity: 426/1267 - (33%)
• Similarity: 700/1267 - (55%)
• Gaps: 147/1267 - (11%)

  Fly    30 IEMENFKSYRGHIVVGPLKQFNAVIGPNGSGKSNFMDAISFVMGEKTSSLRVKRLNDLIHGSSIG 94
            :|:|||||||||.::||.:.|.::|||||:||||.|||||||:|.|:|.||...:.:||:.   |
pombe     7 LEVENFKSYRGHQIIGPFEDFTSIIGPNGAGKSNLMDAISFVLGVKSSHLRSTNVKELIYR---G 68

  Fly    95 KPVSR------------SCYVTAKFVLNEERHMDFQRAVI-GGSSEYRINGESVSSSTYLNKLEK 146
            |.:.|            :.||...:.|:.....:::||:. .|::||:|:.|.|:.|.|...|:|
pombe    69 KILQRDNTDFTDSSNPTTAYVKLMYELDNGEQREYKRAITPSGATEYKIDEEIVTFSEYCGSLQK 133

  Fly   147 IGINVKAKNFLVFQGAVENIAMKTPKERTALFEEISGSGLLKDDYNRLKQEMIVAEEETQFTYQK 211
            ..|.|:|:|||||||.||.||.::|.|.:.|.|:||||...|.:|::.|.|...|...:..::.|
pombe   134 ENILVRARNFLVFQGDVETIASQSPLELSKLVEQISGSLEYKSEYDKSKDEQDKAVNLSAHSFNK 198

  Fly   212 KKGIAAERKEAKHEKMEADRYTRLQNEYNEKQVEYQLFRLFHVERDIRKFTSDL-EVRQQEVKAV 275
            |:||.||.::.:.:|.||:||...:.:.:..|:.|.|::|||:|:.|....::: .::...::.:
pombe   199 KRGINAELRQYQEQKTEAERYQSQKEKRDSAQLVYLLWKLFHLEKSISSNMAEVTRLKADSIQLI 263

  Fly   276 EQRKEAADEILREKKKDAGKITRDLAKIDQEIREFETQMNKRRPLYIKAKEKVTHCKKKLISLQ- 339
            |:|.|...||.:.|:|: |.|.|:|...|:::|:.|..:..:||..|...||....|..|..:|
pombe   264 ERRDENTKEIEKLKEKE-GSIRRNLLAFDRKVRKQEKLIASKRPELISIAEKALESKSNLRKIQR 327

  Fly   340 KTLETARE-ADNAHQSDIRKLEKQLADVEALKKRFEDEIENESQRRGKSVNMEEGLVQEYDRLKQ 403
            |..|..:: :|.|  |.::.||.||..:.|.:|.|..:::.:.|.:|..:..|:  .:||:.|:.
pombe   328 KAAEIEKDYSDQA--STLQVLENQLTSLSAAEKEFLKDMQEKEQLKGLRLLPED--KEEYEGLRS 388

  Fly   404 EAEATATQYRSELDSVNREQKSEQDTLDGETNRRASVEESFKKLTLQREEAVKRRD--------K 460
            ||:...:....:|.::||..|....:.|..|:....:|...|.|    .|:|...|        |
pombe   389 EADKLNSNLLFKLQTLNRNIKVTSQSKDSLTSIVGDLESKIKSL----HESVSSLDTERADLLAK 449

  Fly   461 LMDHIKSSQAALEEQNRIKDELRRDVGTSKE---KIAEKQRELEDVRDQLGDAKSDKHEDARRKK 522
            :.:.|:|.:  ||:.::.|..|     |..|   |..|...||:....::.:|.:|::|..:..|
pombe   450 INEKIESLE--LEKHDQQKKRL-----TYSELFHKTQELNEELQSCLQKILEASADRNESKQDAK 507

  Fly   523 KQEVVELFKKQVPGVYDRMINMCQPTHKRYNVAVTKVLGKFMEAIIVDTEKTARHCIQILKEQML 587
            |:|.:...|:..|.|..|:|::|.||.|:|..|:...|||..:||:|:|:..|:.||..:|||.:
pombe   508 KREALYALKRIYPEVKGRIIDLCTPTQKKYESAIAAALGKNFDAIVVETQAVAKECIDYIKEQRI 572

  Fly   588 EVETFLPLDYLQVKPLKERLRNISDPRNVRLVFDVLKFEPQEIERAVLFATGNALVCETPEDAMK 652
            .:.||.|:|.:...|:.::.|...  :..||..|||.|| .|.||.::.|.||.|:|    |:|.
pombe   573 GIMTFFPMDTIAASPVNQKFRGTH--KGARLAIDVLNFE-SEYERVMISAVGNTLIC----DSMT 630

  Fly   653 VAYEID-RSRFDA--LALDGTFYQKSGLISGGSHDLARKAKRWDEKHMAQLKMQKERLQEELKEL 714
            ||.::. ..|.:|  :.|:||...|:|||:|||.: .|.||.||:.....|...|:||..::.|:
pombe   631 VARDLSYNKRLNAKTVTLEGTVIHKTGLITGGSSN-NRSAKHWDDHDFDLLTQTKDRLMHQIGEI 694

  Fly   715 VKKSRKQS---------ELATVESQIKGLENRLKYSMV--DLESSKKSISQYDNQLQQVQSQLDE 768
              :.:|.|         :|.::||:|..|::  ||::|  .:|..||.|..|::.:::.|
pombe   695 --EYQKSSCVITESDTVKLHSLESEISLLKD--KYTVVSRSVEDKKKEIGHYESLIKEKQ----- 750

  Fly   769 FGPKILEIERRMQNREEHIQEIKENMNNVEDKVYASFCRRLGVKNIRQYEERELVMQQERARKRA 833
              |.:.|:|..::|..:...|::..:..||:|:::.||:|:|:.:|..|:|......|...:|:.
pombe   751 --PHLSELEMELRNFVKSRDELQIQVEKVEEKIFSGFCKRIGISDIHTYDEIHRTFTQSFTQKQL 813

  Fly   834 EFEQQIDSINSQLDFEKQK--DTKKNVERWERSVQDEEDALEGLKLAEARYLKEIDEDKEKMEKF 896
            ||.:|...:.:::.||||:  ||:..:||..                     |.|::|:|.::.:
pombe   814 EFTKQKSLLENRISFEKQRVSDTRLRLERMH---------------------KFIEKDQESIDNY 857

  Fly   897 KQDKQAKKQAVDDMEEDISKARKDVAN---------------------LAKEIHNVGSHLSAVES 940
            :|:::|.:..|...|.::...::|.|:                     |..|:..:..:::.:||
pombe   858 EQNREALESEVATAEAELELLKEDFASENSKTEKILLAASEKKLVGKRLVSELTKLSGNITLLES 922

  Fly   941 KIEAKKNERQNILLQAKTDCIVVPLLRGSL-----DDAVRQSD------PDVPSTSAAMENI-IE 993
            :|:...:|...||.:.|.:.|.|||..|||     ||.....|      |..|..:  .|.. :|
pombe   923 EIDRYVSEWHAILRKCKLEDIDVPLREGSLTSIPIDDVSNSGDITMGEEPSEPVIN--FEKFGVE 985

  Fly   994 VDYSSLPREYTKLKDDSAFKKTHEMLQKDLQSKLDVLERIQTPNMKALQKLDAVTEKVQSTNEEF 1058
            |||..|..|   |::|.: :....:||:.|:...:.|::: :||::|:::|:.|..::...:|||
pombe   986 VDYDELDEE---LRNDGS-ESMASVLQEKLREYSEELDQM-SPNLRAIERLETVETRLAKLDEEF 1045

  Fly  1059 ENARKKAKRAKAAFERVKNERSSRFVACCQHISDAIDGIYKKLARNEA----AQAYIGPDNPEEP 1119
            ..|||.||.||..|..||.:|..:|.|...|||:.||.|||:|.::.|    ..||:..|:.:||
pombe  1046 AAARKAAKNAKERFNAVKQKRLQKFQAAFSHISEQIDPIYKELTKSPAFPLGGTAYLTLDDLDEP 1110

  Fly  1120 YLDGINYNCVAPGKRFQPMNNLSGGEKTIAALALLFSTHSFHPAPFFVLDEIDAALDNTNIGKVA 1184
            ||.||.::.:.|.|||:.|:.|||||||:|||||||:.||:.|:|||||||||||||.||:.|:|
pombe  1111 YLGGIKFHAMPPMKRFRDMDQLSGGEKTMAALALLFAIHSYQPSPFFVLDEIDAALDQTNVTKIA 1175

  Fly  1185 SYIRDH-TTNLQTIVISLKEEFYGHADALVGI 1215
            :|||.| ::..|.:|||||.:.:..::|||||
pombe  1176 NYIRQHASSGFQFVVISLKNQLFSKSEALVGI 1207

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC1	NP_651211.2	SMC_N	26..1222	CDD:481474	426/1267 (34%)
psm1	NP_596049.2	SMC_N	6..1207	CDD:481474	424/1265 (34%)