DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMC1 and psm1

DIOPT Version :9

Sequence 1:	NP_651211.2	Gene:	SMC1 / 42853	FlyBaseID:	FBgn0040283	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	NP_596049.2	Gene:	psm1 / 2540557	PomBaseID:	SPBC29A10.04	Length:	1228	Species:	Schizosaccharomyces pombe

Alignment Length:	1267	Identity:	426/1267 - (33%)
Similarity:	700/1267 - (55%)	Gaps:	147/1267 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 IEMENFKSYRGHIVVGPLKQFNAVIGPNGSGKSNFMDAISFVMGEKTSSLRVKRLNDLIHGSSIG 94
            :|:|||||||||.::||.:.|.::|||||:||||.|||||||:|.|:|.||...:.:||:.   |
pombe     7 LEVENFKSYRGHQIIGPFEDFTSIIGPNGAGKSNLMDAISFVLGVKSSHLRSTNVKELIYR---G 68

  Fly    95 KPVSR------------SCYVTAKFVLNEERHMDFQRAVI-GGSSEYRINGESVSSSTYLNKLEK 146
            |.:.|            :.||...:.|:.....:::||:. .|::||:|:.|.|:.|.|...|:|
pombe    69 KILQRDNTDFTDSSNPTTAYVKLMYELDNGEQREYKRAITPSGATEYKIDEEIVTFSEYCGSLQK 133

  Fly   147 IGINVKAKNFLVFQGAVENIAMKTPKERTALFEEISGSGLLKDDYNRLKQEMIVAEEETQFTYQK 211
            ..|.|:|:|||||||.||.||.::|.|.:.|.|:||||...|.:|::.|.|...|...:..::.|
pombe   134 ENILVRARNFLVFQGDVETIASQSPLELSKLVEQISGSLEYKSEYDKSKDEQDKAVNLSAHSFNK 198

  Fly   212 KKGIAAERKEAKHEKMEADRYTRLQNEYNEKQVEYQLFRLFHVERDIRKFTSDL-EVRQQEVKAV 275
            |:||.||.::.:.:|.||:||...:.:.:..|:.|.|::|||:|:.|....::: .::...::.:
pombe   199 KRGINAELRQYQEQKTEAERYQSQKEKRDSAQLVYLLWKLFHLEKSISSNMAEVTRLKADSIQLI 263

  Fly   276 EQRKEAADEILREKKKDAGKITRDLAKIDQEIREFETQMNKRRPLYIKAKEKVTHCKKKLISLQ- 339
            |:|.|...||.:.|:|: |.|.|:|...|:::|:.|..:..:||..|...||....|..|..:|
pombe   264 ERRDENTKEIEKLKEKE-GSIRRNLLAFDRKVRKQEKLIASKRPELISIAEKALESKSNLRKIQR 327

  Fly   340 KTLETARE-ADNAHQSDIRKLEKQLADVEALKKRFEDEIENESQRRGKSVNMEEGLVQEYDRLKQ 403
            |..|..:: :|.|  |.::.||.||..:.|.:|.|..:::.:.|.:|..:..|:  .:||:.|:.
pombe   328 KAAEIEKDYSDQA--STLQVLENQLTSLSAAEKEFLKDMQEKEQLKGLRLLPED--KEEYEGLRS 388

  Fly   404 EAEATATQYRSELDSVNREQKSEQDTLDGETNRRASVEESFKKLTLQREEAVKRRD--------K 460
            ||:...:....:|.::||..|....:.|..|:....:|...|.|    .|:|...|        |
pombe   389 EADKLNSNLLFKLQTLNRNIKVTSQSKDSLTSIVGDLESKIKSL----HESVSSLDTERADLLAK 449

  Fly   461 LMDHIKSSQAALEEQNRIKDELRRDVGTSKE---KIAEKQRELEDVRDQLGDAKSDKHEDARRKK 522
            :.:.|:|.:  ||:.::.|..|     |..|   |..|...||:....::.:|.:|::|..:..|
pombe   450 INEKIESLE--LEKHDQQKKRL-----TYSELFHKTQELNEELQSCLQKILEASADRNESKQDAK 507

  Fly   523 KQEVVELFKKQVPGVYDRMINMCQPTHKRYNVAVTKVLGKFMEAIIVDTEKTARHCIQILKEQML 587
            |:|.:...|:..|.|..|:|::|.||.|:|..|:...|||..:||:|:|:..|:.||..:|||.:
pombe   508 KREALYALKRIYPEVKGRIIDLCTPTQKKYESAIAAALGKNFDAIVVETQAVAKECIDYIKEQRI 572

  Fly   588 EVETFLPLDYLQVKPLKERLRNISDPRNVRLVFDVLKFEPQEIERAVLFATGNALVCETPEDAMK 652
            .:.||.|:|.:...|:.::.|...  :..||..|||.|| .|.||.::.|.||.|:|    |:|.
pombe   573 GIMTFFPMDTIAASPVNQKFRGTH--KGARLAIDVLNFE-SEYERVMISAVGNTLIC----DSMT 630

  Fly   653 VAYEID-RSRFDA--LALDGTFYQKSGLISGGSHDLARKAKRWDEKHMAQLKMQKERLQEELKEL 714
            ||.::. ..|.:|  :.|:||...|:|||:|||.: .|.||.||:.....|...|:||..::.|:
pombe   631 VARDLSYNKRLNAKTVTLEGTVIHKTGLITGGSSN-NRSAKHWDDHDFDLLTQTKDRLMHQIGEI 694

  Fly   715 VKKSRKQS---------ELATVESQIKGLENRLKYSMV--DLESSKKSISQYDNQLQQVQSQLDE 768
              :.:|.|         :|.::||:|..|::  ||::|  .:|..||.|..|::.:::.|
pombe   695 --EYQKSSCVITESDTVKLHSLESEISLLKD--KYTVVSRSVEDKKKEIGHYESLIKEKQ----- 750

  Fly   769 FGPKILEIERRMQNREEHIQEIKENMNNVEDKVYASFCRRLGVKNIRQYEERELVMQQERARKRA 833
              |.:.|:|..::|..:...|::..:..||:|:::.||:|:|:.:|..|:|......|...:|:.
pombe   751 --PHLSELEMELRNFVKSRDELQIQVEKVEEKIFSGFCKRIGISDIHTYDEIHRTFTQSFTQKQL 813

  Fly   834 EFEQQIDSINSQLDFEKQK--DTKKNVERWERSVQDEEDALEGLKLAEARYLKEIDEDKEKMEKF 896
            ||.:|...:.:::.||||:  ||:..:||..                     |.|::|:|.::.:
pombe   814 EFTKQKSLLENRISFEKQRVSDTRLRLERMH---------------------KFIEKDQESIDNY 857

  Fly   897 KQDKQAKKQAVDDMEEDISKARKDVAN---------------------LAKEIHNVGSHLSAVES 940
            :|:::|.:..|...|.::...::|.|:                     |..|:..:..:::.:||
pombe   858 EQNREALESEVATAEAELELLKEDFASENSKTEKILLAASEKKLVGKRLVSELTKLSGNITLLES 922

  Fly   941 KIEAKKNERQNILLQAKTDCIVVPLLRGSL-----DDAVRQSD------PDVPSTSAAMENI-IE 993
            :|:...:|...||.:.|.:.|.|||..|||     ||.....|      |..|..:  .|.. :|
pombe   923 EIDRYVSEWHAILRKCKLEDIDVPLREGSLTSIPIDDVSNSGDITMGEEPSEPVIN--FEKFGVE 985

  Fly   994 VDYSSLPREYTKLKDDSAFKKTHEMLQKDLQSKLDVLERIQTPNMKALQKLDAVTEKVQSTNEEF 1058
            |||..|..|   |::|.: :....:||:.|:...:.|::: :||::|:::|:.|..::...:|||
pombe   986 VDYDELDEE---LRNDGS-ESMASVLQEKLREYSEELDQM-SPNLRAIERLETVETRLAKLDEEF 1045

  Fly  1059 ENARKKAKRAKAAFERVKNERSSRFVACCQHISDAIDGIYKKLARNEA----AQAYIGPDNPEEP 1119
            ..|||.||.||..|..||.:|..:|.|...|||:.||.|||:|.::.|    ..||:..|:.:||
pombe  1046 AAARKAAKNAKERFNAVKQKRLQKFQAAFSHISEQIDPIYKELTKSPAFPLGGTAYLTLDDLDEP 1110

  Fly  1120 YLDGINYNCVAPGKRFQPMNNLSGGEKTIAALALLFSTHSFHPAPFFVLDEIDAALDNTNIGKVA 1184
            ||.||.::.:.|.|||:.|:.|||||||:|||||||:.||:.|:|||||||||||||.||:.|:|
pombe  1111 YLGGIKFHAMPPMKRFRDMDQLSGGEKTMAALALLFAIHSYQPSPFFVLDEIDAALDQTNVTKIA 1175

  Fly  1185 SYIRDH-TTNLQTIVISLKEEFYGHADALVGI 1215
            :|||.| ::..|.:|||||.:.:..::|||||
pombe  1176 NYIRQHASSGFQFVVISLKNQLFSKSEALVGI 1207

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMC1	NP_651211.2	Smc	26..1216	CDD:224117	426/1267 (34%)
		ABC_SMC1_euk	27..>171	CDD:213242	68/153 (44%)
		SMC_hinge	535..653	CDD:214944	46/117 (39%)
		DUF4700	<697..>810	CDD:292399	32/123 (26%)
		ABC_SMC1_euk	<1130..1232	CDD:213242	54/87 (62%)
psm1	NP_596049.2	Smc	3..1228	CDD:224117	426/1267 (34%)
		ABC_SMC1_euk	4..>170	CDD:213242	73/165 (44%)
		DUF342	<428..523	CDD:302792	26/105 (25%)
		SMC_hinge	520..635	CDD:214944	48/121 (40%)
		ABC_SMC1_euk	<1120..1223	CDD:213242	54/88 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	651	1.000	Domainoid score	I20
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4597
Inparanoid	1	1.050	650	1.000	Inparanoid score	I127
OMA	1	1.010	-	-		QHG53603
OrthoFinder	1	1.000	-	-		FOG0001963
OrthoInspector	1	1.000	-	-		oto101614
orthoMCL	1	0.900	-	-		OOG6_101499
Panther	1	1.100	-	-	LDO	PTHR18937
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1351
SonicParanoid	1	1.000	-	-		X1284
TreeFam	1	0.960	-	-
	14	13.860