Protein Alignment SMC1 and Smc5

DIOPT Version :10

• Sequence 1: NP_651211.2
• Gene: SMC1 / 42853
• FlyBaseID: FBgn0040283
• Length: 1238
• Species: Drosophila melanogaster
• Sequence 2: NP_001413081.1
• Gene: Smc5 / 226026
• MGIID: 2385088
• Length: 1102
• Species: Mus musculus
• Alignment Length: 1261
• Identity: 250/1261 - (19%)
• Similarity: 479/1261 - (37%)
• Gaps: 365/1261 - (28%)

  Fly    20 PDDETAFLE----YIEMENFKSYRGHIVVGPLKQFNAVIGPNGSGKSNFMDAISFVMGEKTSSLR 80
            |.....|:|    .|.||||.:| ....|.|....|.:||.||:|||:.:.||...:..|.:.:.
Mouse    42 PRPSGTFVEGSIVRIAMENFLTY-DICEVSPGPHLNMIIGANGTGKSSIVCAICLGLAGKPAFMG 105

  Fly    81 VKRLNDLIHGSSIGKPVSRSCYVTAKFVLNEE-----------RHMDFQRAVIGGSSEYRINGES 134
                    ....:|..|.|.|   :|.::..|           |.:|    ||...|.:.||.:.
Mouse   106 --------RADKVGFFVKRGC---SKGLVEIELFRTSGNLIITREID----VIKNQSFWFINKKP 155

  Fly   135 VSSSTYLNKLEKIGINVKAKNFLVFQGAVENIAMKTPKERTALFEEISGSGLLKDDYNRLKQEMI 199
            |:......::..:.|.            |.|:....|:::...|.::|            |.|::
Mouse   156 VTQKIVEEQVAALNIQ------------VGNLCQFLPQDKVGEFAKLS------------KIELL 196

  Fly   200 VAEEET-----QFTYQKKKGIAAERKEAKHEKMEADRYTRLQNEYNEKQVEYQLFRLFHVERDIR 259
            .|.|::     ...|.      .|.|..:.::.:.:...:.:.||.||.|:    |....::|:.
Mouse   197 EATEKSVGPPEMHRYH------CELKNFREKEKQLETSCKEKTEYLEKMVQ----RNERYKQDVE 251

  Fly   260 KFTS------------------DLEVRQQEVKAVEQRKEAADEILREKKKDAGKITRDLAKIDQE 306
            :|..                  :.|..:||.:.|:..::...|.:|:.|:....:||.:.:||::
Mouse   252 RFYERKRHLDLIEMLEAKRPWVEYENVRQEYEGVKLIRDRVKEEVRKLKEGQIPMTRRIEEIDRQ 316

  Fly   307 IREFETQMNKRRPLYIKAKEKVTHCKKKLISLQKTLETAREADNAHQSDIRKLEKQLADV-EALK 370
                      |..|.::.|||.|..|:           |.:.....|..|.:.::|:.:: :||.
Mouse   317 ----------RHTLEVRIKEKSTDIKE-----------ASQKCKQRQDLIERKDRQIKELQQALT 360

  Fly   371 KRFEDEIENESQRRGKSVNMEEGLVQEYDRLKQEAEATATQYRSELDSV-NREQKSEQDTLDGET 434
            .:     :||...|.|.::....::::              .:|||.:. |.|....|  :|..|
Mouse   361 VK-----QNEELDRQKRISNTRKMIED--------------LQSELKTAENCENLQPQ--IDTVT 404

  Fly   435 NRRASVEESFKKLTLQREEAVKRRDKLMDHIKSSQAALEEQNR-IKDELRRDVGTSKEKIAEKQR 498
            |....|:|  :|...:.|...|:|:|.|         ||:|.| :.|.:.|
Mouse   405 NDLRRVQE--EKALCEGEIIDKQREKEM---------LEKQRRSVSDHITR-------------- 444

  Fly   499 ELEDVRDQLGDAKSDKHEDARRKKKQEVVEL------FKKQVPGVYDRMINMCQPTHKRYNVAVT 557
                 .|.|.:.|.||.....|.....|:.|      ||::|          |:|.....|:...
Mouse   445 -----FDNLMNQKEDKLRQRYRDTYDAVLWLRNNRDRFKQRV----------CEPIMLTINMKDN 494

  Fly   558 KVLGKFMEAIIVDTEKTARHCIQILKEQMLEVETFLPLDYLQVKPLKERLRNISDPRNVRLVFDV 622
            | ..|::|..|...:..|     .:.|...::|.|              ||.:.|.:.:|:
Mouse   495 K-NAKYVENHISSNDLRA-----FVFESQEDMEIF--------------LREVRDNKKLRV---- 535

  Fly   623 LKFEPQEIERAVLFATGNALVCETPEDAMKVAYEIDRS---RFDALALDGTFYQKSGLISGGSHD 684
                             ||::      |.|::| .|::   ..:.|...|.|.....|.......
Mouse   536 -----------------NAVI------APKISY-ADKAPSRSLNDLKQYGFFSYLRELFDAPDPV 576

  Fly   685 LARKAKRWDEKHMAQLKMQKERLQEELKELVKKSRKQSELATVESQIKGLENRLKYSMVDLESSK 749
            ::....::   |:.::.:..||.:|.::.:::::|.: ::.|.|.         ||.:.....|.
Mouse   577 MSYLCCQY---HIHEVPVGTERTRERIERVIQETRLK-QIYTAEE---------KYVLKTSVYSN 628

  Fly   750 KSISQYDNQLQQVQSQLDEFGPKILEIERRMQNREEHIQEIKENMNNVEDKVYA--SFCRRLGVK 812
            |.||      .....::.:|....:::|:| ::.||.::|:...:..|:..:.|  ...|.|.:|
Mouse   629 KVIS------SNTSLKVAQFLTVTVDLEQR-RHLEEQLKEMNRQLEAVDSGLAALRDTNRHLELK 686

  Fly   813 -NIRQYEERELVMQQERARKRAEFEQQIDSINSQLDFEKQKDTKKNVERWER---------SVQD 867
             |..:.:::||:   ||..::.:.||:|.|..:.:...:| || .|:|..||         :||.
Mouse   687 DNELRLKKKELL---ERKTRKRQLEQKISSKLASIRLMEQ-DT-CNLEEEERKASTKIKEINVQK 746

  Fly   868 EE--DALEGL-KLAEARYLKEID---------EDKEKME-----KFKQDKQAKKQAV--DDMEED 913
            .:  ..|.|| |:..:..::::|         .:|.|:|     ...|.:..::|.:  ||..:.
Mouse   747 AKLVTELTGLVKICTSFQIQKVDLILQNTTVISEKNKLEADYMASSSQLRVTEQQFIELDDNRQR 811

  Fly   914 ISKARKDVANLAKEIHNVGSHLSAVESKIEAKKNERQNILLQAKTDCIVVPLLRGSLDDAVRQSD 978
            :.:..|::...|:::.|:.:. .||..:.:.:                 ||.:......:...:.
Mouse   812 LLQKCKELMKKARQVCNLSAD-QAVPQEFQTQ-----------------VPTIPNGHSSSPPMAF 858

  Fly   979 PDVPSTSAAMENIIEVDYSSLPREYTKLKDDSAFKKTHEMLQKDLQSKLDVLERIQTPNMKALQK 1043
            .|:|:|      :.|:| :.|..|.::.   |.|...:..:..:..||.:|             :
Mouse   859 QDLPNT------LDEID-ALLTEERSRA---SCFTGLNPSVVVEEYSKREV-------------E 900

  Fly  1044 LDAVTEKVQSTNEEFENARKKAKRAKAAF--------ERVKNERSSRFVACCQHISDAIDGIYKK 1100
            :..:||::|....|.:..|:...:.|..:        |:: ||:.|.|.:..|.
Mouse   901 IQQLTEELQGKKVELDEYRENISQVKERWLNPLKELVEKI-NEKFSNFFSSMQC----------- 953

  Fly  1101 LARNEAAQAYIGPDNPEEPYLDGINYNCVAPGKRFQPMNNL--------SGGEKTIAALALLFST 1157
                 |.:..:..:|.|:....||....     :|:....|        ||||::::.:..|.:.
Mouse   954 -----AGEVDLHTENEEDYDKYGIRIRV-----KFRSSTQLHELTPHHQSGGERSVSTMLYLMAL 1008

  Fly  1158 HSFHPAPFFVLDEIDAALDNTNIGKV 1183
            ...:..||.|:|||:..:|..|..:|
Mouse  1009 QELNRCPFRVVDEINQGMDPINERRV 1034

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC1	NP_651211.2	SMC_N	26..1222	CDD:481474	249/1255 (20%)
Smc5	NP_001413081.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..44		1/1 (100%)
		P-loop containing Nucleoside Triphosphate Hydrolases	51..>196	CDD:476819	41/184 (22%)
		SMC_prok_B	196..1054	CDD:274008	206/1067 (19%)
		Flexible hinge	441..644		51/298 (17%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<976..1078	CDD:476819	16/64 (25%)