DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SMC1 and smc4

DIOPT Version :9

Sequence 1:NP_651211.2 Gene:SMC1 / 42853 FlyBaseID:FBgn0040283 Length:1238 Species:Drosophila melanogaster
Sequence 2:NP_775360.2 Gene:smc4 / 192332 ZFINID:ZDB-GENE-020419-21 Length:1289 Species:Danio rerio


Alignment Length:1340 Identity:340/1340 - (25%)
Similarity:614/1340 - (45%) Gaps:263/1340 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 DDVAQRVATAP----VRKPDDETAFLEYIEMENFKSYRGHIVVGPL-KQFNAVIGPNGSGKSNFM 65
            :::...:..||    ..:|......:.:|...|||||.|..::||. |:|:.:||||||||||.:
Zfish    58 EEILGSIPPAPPPAMSSEPGAPRLMITHIVNRNFKSYAGEQILGPFHKRFSCIIGPNGSGKSNVI 122

  Fly    66 DAISFVMGEKTSSLRVKRLNDLIHGSSIGKPVSRSCYVTAKF--VLNEERHMDFQRAVIGGSSEY 128
            |::.||.|.:...:|.|:|:.||| ||.|.|..:||.|...|  ::::|.. |:.  ||..||.|
Zfish   123 DSMLFVFGYRAQKIRSKKLSVLIH-SSDGHPDIQSCTVEVHFQKIIDKEGD-DYD--VIPDSSFY 183

  Fly   129 --RINGESVSSSTYLNK-----------LEKIGINVKAKNFLVFQGAVENIAMKTPKERT----- 175
              |..|:..||:.|:|.           |...||::....||:.||.||.|||..||.:|     
Zfish   184 VARTAGKDNSSAYYINTKKATFKDVGTLLRSHGIDLDHNRFLILQGEVEQIAMMKPKGQTEHDEG 248

  Fly   176 --ALFEEISGSGLLKDDYNRLKQEMIVAEEETQFTYQKKKGIAAERKEAKHEKMEADRYTRLQNE 238
              ...|:|.||..||:..|.|.:.:....|:......:.|.:..|:...:.||.:|..:..|:|:
Zfish   249 MLEYLEDIIGSCRLKEPINILCRRVEALNEQRGEKLNRVKMVEKEKSALEGEKNKAVDFLSLEND 313

  Fly   239 YNEKQVEYQLFRLFHVERDIRKFTSDLEVRQQEVKAVEQRKEAAD------EILREKKKDAGKIT 297
            ..:|:   .|...|:| .|::...|..|..:|:::  |..|:.:|      |.::.|.:|...:.
Zfish   314 IFKKR---NLLCHFYV-HDLQSRVSVKEAEKQQIQ--EDTKDLSDKSSQLTEEMKSKNEDLKAVE 372

  Fly   298 RDLAKIDQEIREFETQMNKRRPL---YIKAKEKVTHCKKKLISLQKTLETARE------------ 347
            :.|.|:.:.|   |:|..|...|   .::.:||:.|.|.|...|||.|:..:|            
Zfish   373 KKLTKLTKYI---ESQKEKFTQLDLQDVEVREKLKHTKSKTKKLQKQLQKDQEKLEEVRGVPASS 434

  Fly   348 -----ADNAHQSDIRK---LEKQ-LADV-EALKKRF----EDEIENESQ--RRGKSVNMEEGLVQ 396
                 ..:|.:.::.|   ||:| ||:| |:||:..    ||:.:.|.:  ...||||...   .
Zfish   435 EKIITEASAQKEELEKKKLLEEQKLAEVMESLKEETKGLQEDKEKKEKELLELSKSVNETR---S 496

  Fly   397 EYDRLKQEAEATATQYRSELDSVNREQKSEQDTLDGETNRRASVEESFKKLTLQREEAVKRRDKL 461
            ..|..:.|.:...:|:.:.::.:|:.:.:.|:|:|....|||::::...|:..|.|:        
Zfish   497 RMDVAQSELDIYLSQHNTAINQLNQAKSALQETVDTLRERRAAIKDLQVKIPAQEEQ-------- 553

  Fly   462 MDHIKSSQAALEEQNRIKDELRRDVGTSKEKIAEKQRELEDVRDQLGDAKSDKHEDARRKKKQEV 526
               :|..:..||:.:....:.|..||..::|:||              |||....:..|.|..:.
Zfish   554 ---LKKDERELEQISEQDKQTRAQVGDMRQKVAE--------------AKSSLSSNRSRSKVLDT 601

  Fly   527 VELFKK--QVPGVYDRMINMCQPTHKRYNVAVTKVLGKFMEAIIVDTEKTARHCIQILKEQMLEV 589
            :...|:  ::||:..|:.:: ....::|:||::...|. ::.|:|||..||:.|:..||.|.:.|
Zfish   602 LMQQKRSGKIPGILGRLGDL-GAIDEKYDVAISSSCGS-LDNILVDTIDTAQKCVTFLKAQNIGV 664

  Fly   590 ETFLPLDYLQVKPLKERLRNISDPRNVRLVFDVLKFEPQEIERAVLFATGNALVCETPEDAMKVA 654
            .||:.||  ::|..::.:.:||.|.|:..:||:::.:.:.:..|..||..:.||.:..|.|.:||
Zfish   665 ATFIGLD--KMKVWQQSMGSISTPENIPRLFDMVRVKDESVRPAFYFALRDTLVAKDLEQATRVA 727

  Fly   655 YEIDRSRFDALALDGTFYQKSGLISGGSHDLARKAKRWDEKHMAQLKMQKERL---------QEE 710
            ::.|: |:..:.|.|...:::|.::||..                 ::.|.|:         ||:
Zfish   728 FQKDK-RWRVVTLQGQIIEQAGTMTGGGG-----------------RVMKGRMGSSVCADVTQEQ 774

  Fly   711 LKELVKKSRKQ-SELATVESQIKGLENRLKYSMVDLESSKKSISQYDNQLQQVQSQLDEFGPKIL 774
            |.::.....|: ::|...:.:...||.::..:..:|...|.::.:|...:|.:..|.....|:|.
Zfish   775 LDKMESALNKEVTQLQDCQKRKNQLEEKVHKARCELRDMKNTLEKYTATIQSLTEQELHLKPQIK 839

  Fly   775 EIE-------------RRMQNREEHIQEIKENMNNVEDKVYASFCRRLGVKNIRQYEERELVMQQ 826
            ::|             ::|:...|..::..|..:|...||.|.      ||.:     ..|::..
Zfish   840 DLEANVIAAAPDKAKQKQMEKSLEAYRKDFEAASNKAGKVEAE------VKRL-----HTLIVDI 893

  Fly   827 ERARKRAEFEQQIDSINSQLD-------------------FEKQKDTKKNVERWERSVQDEEDAL 872
            ...:.:|: :.::|.||:|||                   .:|.:|   .|.|.|:.:.:.|..:
Zfish   894 NSHKLKAQ-QDKLDQINTQLDQCSSAVTKAQVAIKTAGRNLKKSED---GVSRLEQEISENEKLM 954

  Fly   873 EGLKLAEARYLKEIDEDK-EKMEKFKQDKQAKKQAVDD----------MEEDISKARKDVANLAK 926
            |.|    ...||:::|.. |.|:.::|.::|..:..|.          ::|.....:|:..::..
Zfish   955 EEL----TEQLKKLEEQAGEIMQSYQQAEEALPEVQDQHRAVVQEIKALQEQEHALQKESLSVRL 1015

  Fly   927 EIHNVGSHLSAVESKIEAKKNERQNILLQAKTDCIVVPLLRGSLDDAVRQ-SDPDVPSTSAAMEN 990
            ::.::.:.::...:||:..:.|...:.|. ..|.:....|.....|.::. .:|||         
Zfish  1016 KVEHIDTAITECHNKIKHWQKEASKLCLH-HIDGVPAEELPALNPDQLQDIGNPDV--------- 1070

  Fly   991 IIEVDYSSLPREYTKLKDD----SAFKKTHEMLQKDLQSKLDVLERIQTPNMKALQKLDAVTEKV 1051
             |:.:.:.|......:|.:    :.|||..|:          .|:|:        .:||.:|.:.
Zfish  1071 -IKNEIALLEDRCANMKPNLGAIAEFKKKEEL----------YLQRV--------AELDDITTQR 1116

  Fly  1052 QSTNEEFENARKKAKRAKAAFERVKNERSSRFVACCQHISDAIDGIYKKLARNEAAQAYIGPD-- 1114
            .|.....|:.||              :|...|:|....|::.:...|:.|.        :|.|  
Zfish  1117 DSFKRGCEDLRK--------------QRLHEFMAGFNIITNKLKENYQMLT--------LGGDAE 1159

  Fly  1115 ----NPEEPYLDGINYNCVAPGKRFQPMNNLSGGEKTIAALALLFSTHSFHPAPFFVLDEIDAAL 1175
                :..:|:.:||.::...|.|.::.:.||||||||:::|||:|:.|.|.|.|.:.:|||||||
Zfish  1160 LELVDSLDPFSEGIMFSVRPPKKSWKKIYNLSGGEKTLSSLALVFALHHFKPTPLYFMDEIDAAL 1224

  Fly  1176 DNTNIGKVASYIRDHTTNLQTIVISLKEEFYGHADALVGI 1215
            |..|:..||.||.:.|.|.|.|:|||:...:..||.|:||
Zfish  1225 DFKNVSIVACYIYEQTKNAQFIIISLRNNMFEMADRLIGI 1264

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SMC1NP_651211.2 Smc 26..1216 CDD:224117 337/1316 (26%)
ABC_SMC1_euk 27..>171 CDD:213242 64/159 (40%)
SMC_hinge 535..653 CDD:214944 36/117 (31%)
DUF4700 <697..>810 CDD:292399 24/135 (18%)
ABC_SMC1_euk <1130..1232 CDD:213242 43/86 (50%)
smc4NP_775360.2 ABC_SMC4_euk 81..>240 CDD:213241 64/162 (40%)
SMC_N 82..1273 CDD:280601 337/1316 (26%)
DUF4349 <274..435 CDD:305044 39/169 (23%)
SMC_hinge 612..726 CDD:214944 36/117 (31%)
MIT_CorA-like <866..1025 CDD:294313 33/177 (19%)
ABC_SMC4_euk <1180..1274 CDD:213241 43/85 (51%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1196
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D326079at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.820

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