DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMC1 and smcl-1

DIOPT Version :9

Sequence 1:	NP_651211.2	Gene:	SMC1 / 42853	FlyBaseID:	FBgn0040283	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	NP_509956.2	Gene:	smcl-1 / 183453	WormBaseID:	WBGene00008085	Length:	537	Species:	Caenorhabditis elegans

Alignment Length:	460	Identity:	111/460 - (24%)
Similarity:	203/460 - (44%)	Gaps:	84/460 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   784 EEHIQEI-KENMNNVEDKVYASFCRRLGVKNIRQYEERELVMQQERARK----------RAEFEQ 837
            ||::.|: |.|.             |...:||..|.:..|.:.::.|.:          ..||:.
Worm   113 EEYLLELGKMNF-------------RFAGQNISVYNKTTLKVTRKSAEELGAFFDIVSNSIEFKP 164

  Fly   838 QIDSINSQLDFEKQKDTKKNVERWER---SVQDEEDALEGLKLAEARYL--KEIDEDKEKM--EK 895
            :.|.:.::|:|     .:..|.||.:   |::.|::....|.|.:. ||  |||.|.|||.  |:
Worm   165 EYDELKAKLNF-----AESTVLRWAKMIDSIELEKEKFITLTLYKL-YLCDKEIQETKEKFVAEQ 223

  Fly   896 FKQD-KQAKKQ-AVDDMEEDISKA------RKDVANLAKEIHNVGSHLSAVE---SKIEAKKNER 949
            .|.: |.||.. .:....|.|.|.      :.:...:..:.||...:|..|:   |.:..|..||
Worm   224 LKVNAKNAKMPLRISRYSEAIPKQTPSPNFKNNAIVVRPKTHNHYDNLITVDKLNSYLNEKVTER 288

  Fly   950 QNILLQAKTDCIVVPLLRGSLDDAVRQSDPDVPSTSAAMENIIEVDYSSLPREYTKLKDD---SA 1011
            :.:|..|        :...:::....:..|::.:.        |:||:.||..|.|..||   ::
Worm   289 RELLQFA--------VNHPNMNIRFSEEGPNIYAR--------EIDYTELPEYYKKESDDIIATS 337

  Fly  1012 FKKTHEMLQKDL----QSKLDVLERIQTPNMKALQKLDAVTEKVQSTNEEFENARKKAKRAKAAF 1072
            :|::  ||:|::    |..||      ..|:|....:|.:..:::....:...|......|:..:
Worm   338 YKRS--MLEKEIKKIRQCWLD------ENNIKDDANIDNINMRIKEATTKHTLALNIESEARLNW 394

  Fly  1073 ERVKNERSSRFVACCQHISDAIDGIYKKLARNEAAQAYIGPDNPEEPYLDGINYNCVAPGKRFQP 1137
            |:::..||:||......:..::..||.::|::|.:.|::.|.:.||||| .|:............
Worm   395 EKLRVMRSARFNNFMAPLQTSLSRIYAEIAQDEDSLAFLRPLDEEEPYL-AIDAFVKERHSEHIS 458

  Fly  1138 MNNLSGGEKTIAALALLFSTHSFHPAPFFVLDEIDAALDNTNIGKVASYIRDHTTNLQT-IVISL 1201
            .....||.:.|..|||:|:.|.:.|:|..|:|:||..|.:....|:..|:   :...|| .:::.
Worm   459 TRTFHGGSRMIVDLALIFAIHEWKPSPLVVIDDIDRNLYHEASKKIEPYL---SRQKQTQFIVTT 520

  Fly  1202 KEEFY 1206
            ||:.|
Worm   521 KEDSY 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMC1	NP_651211.2	Smc	26..1216	CDD:224117	111/460 (24%)
		ABC_SMC1_euk	27..>171	CDD:213242
		SMC_hinge	535..653	CDD:214944
		DUF4700	<697..>810	CDD:292399	6/26 (23%)
		ABC_SMC1_euk	<1130..1232	CDD:213242	22/78 (28%)
smcl-1	NP_509956.2	ABC_ATPase	8..>123	CDD:330224	4/9 (44%)
smcl-1	NP_509956.2	SMC_N	<112..520	CDD:330553	108/453 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18937
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910