Protein Alignment SMC1 and smc-3

DIOPT Version :9

• Sequence 1: NP_651211.2
• Gene: SMC1 / 42853
• FlyBaseID: FBgn0040283
• Length: 1238
• Species: Drosophila melanogaster
• Sequence 2: NP_001255118.1
• Gene: smc-3 / 176559
• WormBaseID: WBGene00004873
• Length: 1205
• Species: Caenorhabditis elegans
• Alignment Length: 1324
• Identity: 313/1324 - (23%)
• Similarity: 578/1324 - (43%)
• Gaps: 275/1324 - (20%)

  Fly    27 LEYIEMENFKSYRGHI-VVGPLKQFNAVIGPNGSGKSNFMDAISFVMGEKTSSLRVKRLNDLIHG 90
            ::.:.:..|:||:.:. |.|...:.|.|:|.||||||||..||.||:.::.:.|:.::...|:|
 Worm     3 IKEVRITGFRSYKDNTNVSGFSPRSNVVVGRNGSGKSNFFHAIQFVLSDEYAHLKEEQRLGLLH- 66

  Fly    91 SSIGKPVSRSCYVTAKFVLNEERHMDFQ-------RAVIGGSSEYRINGESVSSSTYLNKLEKIG 148
            .|.|..|:.: .|...|..:|:|.|.|:       |.|.....:|.|:.:.|..:..:|.:|..|
 Worm    67 ESTGPKVAHA-RVEITFDNSEKRLMAFENSEVKIVRQVGKKKDQYYIDNKMVPRAEVVNLMESAG 130

  Fly   149 INVKAKNFLVFQGAVENIAMKTPKERTALFEEISGSGLLKDDYNRLKQEMIVAEEETQFTYQKKK 213
            .:.....::|.||.:..:|......:..|..|::|:.:    |:..|:|.:...:||:...:|.:
 Worm   131 FSRSNPYYIVKQGKINELATSPDAYKLKLLREVAGTRV----YDERKEESLKILKETKMKTEKIQ 191

  Fly   214 GIAA---ERKEA-KHEKMEADRYTRLQNEYNEKQVEYQLFRLFHVERDIRKFTSD---LEVRQQE 271
            |:..   ||.:. ::||.:...|.:|  :..::.|||.::...:.|....|...|   :|:.|::
 Worm   192 GLLKYIDERLQTLENEKEDLKEYQKL--DKTKRSVEYTMYDNTNKEAIKEKTKLDEQKVELNQKD 254

  Fly   272 VKAVEQRKEAADEI--LREKKKDAGKITRDLAKIDQEIREFETQMNKRRPLYIKAKEKVTHCKKK 334
            .....|..:...|:  |:..||....:.|.|.:..:.::..||:|         .:||:| .|.:
 Worm   255 NNVKSQLNDVIAEMAKLKTDKKKLESLGRGLREDKETLQAEETKM---------VEEKMT-LKLE 309

  Fly   335 LISLQKTLETARE---ADNAHQS------DIRKLEKQLADVEALKKRFEDEIENESQRRGKSVNM 390
            :.||.:  |..||   ..||..|      :|.|.|::|   :.:|..:...:|.|| |....:.:
 Worm   310 IDSLNE--ENTRERQGRQNAEHSLQGVGDEIFKNEEEL---DTIKPEYAKLLEEES-RLKTDIRI 368

  Fly   391 EEGLVQEYDRLKQEAEATATQYRSELDSVNREQKSEQDTLDGETNRRAS---VEESFKKLTLQRE 452
            :|...:|.  |.::.:      ||:..||:...|..::.:     ||.|   .:...::.|:|:|
 Worm   369 DESRAKEI--LAKQGQ------RSQFSSVDDRDKFLRNEI-----RRISGLIADNKEREETIQKE 420

  Fly   453 EA-VKRRD-KLMDHIKSSQAALEEQNRIKDELRRDVGTSKEK------IAEK--QRELEDVRDQL 507
            .| |:|.| ||.:.|:|....::| ||.:.:......||.::      :|::  .||.:.:||::
 Worm   421 LADVEREDEKLNNEIQSISRTIDE-NRYEMDTFAAKSTSLKQEYDAAYVAQQTAAREEKAIRDKI 484

  Fly   508 GDAKSD---KHEDARR----------KKKQEVVELFKKQ---------VPGVYDRMINMCQPTHK 550
            |:.:.|   .::..||          ...::|:|.||..         :.|.|..:|.:.: ...
 Worm   485 GNTEQDISAANDQLRRIVARPVYNGITGVRKVIEEFKHDNRNGQHDDVINGYYGTVIELAE-VPD 548

  Fly   551 RYNVAVTKVLGKFMEAIIVDTEKTARHCIQILKEQMLEVE-TFLPLDYLQVKPLKERLRNISDPR 614
            .:..||..:....:...:|:|::.|...::...|..|..| .|.|::.:..    .|.|::|:..
 Worm   549 MFRTAVEVIAQNRLFYHVVETDRIATKILRKFNEMQLPGEINFFPMNRVSA----PRQRDLSNNS 609

  Fly   615 NVRLVFDVLKFEPQEIERAVLFATGNALVCETPEDAMKVAYEIDRSRFDALALDGTFYQKSGLIS 679
            |.|.:.||:.:|.| .::.....|.|.::..|.:.|   |.::....||.:::||....|.|:::
 Worm   610 NARPMSDVIDYEVQ-YDKVFKSITANVIIVRTLDQA---ARDLRNEGFDVVSVDGDQMSKKGVMT 670

  Fly   680 GGSHDLARKAKRWDEKHMAQLKMQKERLQEELKELVKKSRKQSELATVESQIKGLENRLKYSMVD 744
            ||..|..|.        ..:|..||:|..:||.||      |..||..|..::
 Worm   671 GGFIDKKRS--------KLELHTQKDRFTKELAEL------QKSLAEAEKMVR------------ 709

  Fly   745 LESSKKSISQYDNQLQQVQSQLDEFGPKILEIERRMQNREEHIQEIKENMNNVEDKVYASFCRR- 808
             |.:::: .:..|::||.::|:.:|             ..:| :|:.|..|.:..:.|.....:
 Worm   710 -ERTQEA-EKIRNRMQQHENQIGDF-------------HRKH-RELTEAKNAISQQFYMVTSTKE 758

  Fly   809 ------LGVKNIRQYEERELVMQQERARKRAEFEQQIDS-INSQLDFEKQKDTKK---------- 856
                  ||:||    ..|||:.|:|      .|||:|.| ::|||..::::..||
 Worm   759 PKKDQLLGIKN----HLRELLAQKE------NFEQEIGSNMSSQLTSDEEQTVKKLRKKVDEMTK 813

  Fly   857 ---NVERWERSVQDEEDALEGLKLAEARYLKE-----IDE--DKEKMEKFKQDKQAKKQAVDDME 911
               .|.|....:...::|:|.|...:....||     :|:  |.|:..|.:.........:..||
 Worm   814 QLATVSRRRMDLMHRKNAIENLLTKKLYKTKESLTARVDDISDNERRHKLENANAQLTSLLTRME 878

  Fly   912 EDISKARKDVANLAKEIHNVGSHLSA----VESKIEAKKN-ERQNILLQAKTDCIVVPLLRGSLD 971
                ..||.:|....|:.:..:...|    :::.:|.::: |:|....|.:.|.|.      :.:
 Worm   879 ----STRKQLATAISELQDYETKEKALQINIDNVLEQQRDLEKQQADFQLQYDKIT------AKE 933

  Fly   972 DAVRQSDPDVPSTSAAMENIIEVDYSSLPREYTKLKDDSAFKKTHEMLQKDLQSKL----DVLER 1032
            |.|:|...|    |.....::    .:||.:        .|.|...:..::|:.||    :.|::
 Worm   934 DEVKQKRED----SLKKMRLL----GALPTD--------TFSKWQNVKPRELEKKLLECVNELKK 982

  Fly  1033 IQTPNMKAL-QKLDAVTEKVQSTNEEFENARKKAKRAKAAFERVKNERSSRFVACCQHISDAIDG 1096
            .:..|.||| |.:.|.::|     ||......:.|:::.:.|.:.....:|..       :|||.
 Worm   983 YENVNKKALDQYMTASSQK-----EELTKRMAEQKKSEDSIEELLKVLENRKY-------EAIDL 1035

  Fly  1097 IYKKLARN-EAAQAYIGPDNPEEPYL---------DGIN----YNCVAPGKRF---------QPM 1138
            .:|::.:| |.....:.|....:..:         :|||    |..::....|         :.|
 Worm  1036 TFKQVKKNFEQVFKQLVPHGRGKMQMRAREQRDDEEGINSVELYEGISVLVSFVSDDGDSETREM 1100

  Fly  1139 NNLSGGEKTIAALALLFSTHSFHPAPFFVLDEIDAALDNTNIGKVASYIRD-------HTTNLQT 1196
            ..||||:|::.|||::||.....||||::.||||||||..:...||..|:.       .||..:.
 Worm  1101 TQLSGGQKSLVALAIIFSIQKCDPAPFYLFDEIDAALDAQHRKSVADMIQSLSDQAQFVTTTFRP 1165

  Fly  1197 IVISLKEEFYG--------HADAL 1212
            .:::..|:|||        |.|::
 Worm  1166 ELLATAEKFYGVRFRNKVSHIDSV 1189

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC1	NP_651211.2	Smc	26..1216	CDD:224117	313/1324 (24%)
		ABC_SMC1_euk	27..>171	CDD:213242	44/151 (29%)
		SMC_hinge	535..653	CDD:214944	26/118 (22%)
		DUF4700	<697..>810	CDD:292399	23/119 (19%)
		ABC_SMC1_euk	<1130..1232	CDD:213242	35/107 (33%)
smc-3	NP_001255118.1	Smc	1..1198	CDD:224117	313/1324 (24%)
		ABC_SMC3_euk	3..>151	CDD:213239	44/149 (30%)
		SMC_hinge	534..646	CDD:214944	26/120 (22%)
		P-loop_NTPase	<1093..1187	CDD:304359	33/93 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910