Protein Alignment SMC1 and dpy-27

DIOPT Version :9

• Sequence 1: NP_651211.2
• Gene: SMC1 / 42853
• FlyBaseID: FBgn0040283
• Length: 1238
• Species: Drosophila melanogaster
• Sequence 2: NP_497771.1
• Gene: dpy-27 / 175492
• WormBaseID: WBGene00001086
• Length: 1469
• Species: Caenorhabditis elegans
• Alignment Length: 1395
• Identity: 335/1395 - (24%)
• Similarity: 576/1395 - (41%)
• Gaps: 342/1395 - (24%)

  Fly    17 VRKPDDETAFLEYIEMENFKSYRGHIVVGPL-KQFNAVIGPNGSGKSNFMDAISFVMGEKTSSLR 80
            :..||.....:..|.:||||||.|..::||. |....::|||||||||.:||:.||.|.|...:|
 Worm    83 ISDPDGNRMIILNIYVENFKSYAGKHILGPFHKNLTMILGPNGSGKSNVIDALLFVFGFKAGKIR 147

  Fly    81 VKRLNDLIH-GSSIGKPVSRSCYVTAKFVLNEERHMD--------------FQRAV-IGGSSEYR 129
            .|:|:.||: |.:.     .||.||..|.:.::..::              ..|.: ...:|:||
 Worm   148 TKKLSALINSGGNY-----ESCSVTIMFQMVKDMPVENYDKYEVLTDNCVCITRTINRENNSKYR 207

  Fly   130 INGESVSSSTYLNKLEKIGINVKAKNFLVFQGAVENIAM-----KTPKERTAL--FEEISGSGLL 187
            |:.:..|.......|.:.||::....||:.||.||.||:     |.|.|...|  .|:|.|:...
 Worm   208 IDDKDASQKDVQELLLRAGIDMTHNRFLILQGEVEAIALMKPTSKNPNEEGMLEYIEDIVGTNRF 272

  Fly   188 KDDYNRLKQEMIVAEEETQFTYQKKKGIAAERKEAKHEKME-----ADRYTRLQNEYNEK---QV 244
            ....::|...:.:.|.::     .:.|.:..|.|...:..|     ...|....|..|..   :|
 Worm   273 VAPISKLMHRVSLLEHKS-----SQYGASVRRHEGHLKVFEKAMVIGMAYLNTFNNLNYLRGIRV 332

  Fly   245 EYQLFRLFHVERDIRKFTSDLEVRQQEVKAVEQRK----EAADEILREKKKDAGKITRDLAKIDQ 305
            ::.|.|.....||.:   ..|..|..|   :|:.|    ||.||: |:|:.....:...:.:::.
 Worm   333 KHNLCRYAETMRDAK---MSLVTRTGE---LEENKDIMLEAKDEV-RKKETHERSLNSIVTELEN 390

  Fly   306 EIREFETQMNKRRPLYIKAKEKVTHCKKKLISLQKTLETAREADNAHQSDIRKLEKQLADVEALK 370
            :..:::::.|.......|.|:.:..|.:.|..|.|      |.|                 ||.:
 Worm   391 KRIDWQSKKNDWHARDAKRKQGLKSCTQDLGKLMK------ERD-----------------EARR 432

  Fly   371 KRFEDEIENESQRRGKSVNMEEGLVQEYDRLKQE---AEATATQYRSELDSVNREQKSEQDTLDG 432
            ::||.|...|:.|..|. ||:    .|:|:||::   .:.|||:     :.:..:|||..|
 Worm   433 EKFEIETAPENARISKQ-NMQ----LEWDQLKEQENVCQRTATE-----NLIKYDQKSSAD---- 483

  Fly   433 ETNRRASVEESFKKLT---LQREEAVKRRDKLMDHIKSSQAALEEQNRIKDELRRDVGTSKEKIA 494
                ||..::..|||:   ||...|....|.....:|.....:|:..:..|||:   ||.:..:|
 Worm   484 ----RAKHDDLEKKLSDELLQSMRAKAELDVSESELKDMTIMMEQGQKRVDELK---GTLQTMMA 541

  Fly   495 EKQR---ELEDVRDQLGD--AKSDK------H----EDARRKKK----QEVVELFKKQ------- 533
            |..|   ||..|..:|.|  .|.||      |    |...|.||    |||:|....|
 Worm   542 ENIRDNTELNAVTTELQDRKLKFDKAVEKLPHLKSTEQLLRSKKYELDQEVIEASNTQEVTYRHQ 606

  Fly   534 -------------VPGVYDRMINMCQPTHKRYNVAVTKVLGKFMEAIIVDTEKTARHCIQILKEQ 585
                         .||...|:.::.....| ::.|::.|....::..:|.|....|..|....|.
 Worm   607 ATAKLHELKEAGLFPGFKGRLGDLASIPIK-FDTAISTVFFAQLDYHVVQTSDECRIGIGFCHEY 670

  Fly   586 MLEVETFLPLDYLQ----------VKPLKERLRNISDPRNVRLVFDVLKFEPQEIERAVLFATGN 640
            .|...||:.||:|:          :|...|||            ||.:.....||.|...|...:
 Worm   671 KLPRTTFVFLDHLKDTDTSGMDSTMKFPAERL------------FDKIHCVNPEIRREFYFLIHD 723

  Fly   641 ALVCETPEDAMKVAYEIDR---SRFDALALDGTFYQKSGLISGGSH------------------- 683
            .||.::.|:|.:    ||:   .|.....|:|:...:||.::||..
 Worm   724 ILVVDSLEEATR----IDKKYPGRHRYCTLNGSILNRSGALTGGGKPTTGRIRNDNNPNMSGVKK 784

  Fly   684 -DLARKAKRWDEKH----MAQLKMQKERLQEEL---------------KELVKKSRKQ-SELATV 727
             ||: |.:...|||    .|.||:|.:  |||:               :||:..:::| :.:|.:
 Worm   785 VDLS-KLRAAQEKHNHALEAHLKLQLK--QEEIRADNGPIIKQLEIRKRELIMSTKEQKTRIAEL 846

  Fly   728 ESQIKGLENRL----KYSMVDLESSKKSISQYDNQLQQVQSQLDEFGPKILEIERRM-------- 780
            :|.|...|.|:    :.::.||:..:..|:....|:::.|....:...:|.:.:|:|
 Worm   847 KSSIAAHERRMVNYREVTVEDLDEKRAQIADLKRQVEESQKSSAKIKQQIEQYKRKMDRMFMELV 911

  Fly   781 QNREEHIQEIKENMNNVEDKVYASFCRRLGV-----KNIRQYEERELVMQQERARKRAEFE---- 836
            |..::.|::.|:.|..:|..:    .|:..:     .::.|.|::...::.....||:|.:
 Worm   912 QKNKDSIEQAKDRMGQLEQDI----ARQTAIIENNPSHLEQAEKKLSELEHMCLEKRSEADALAQ 972

  Fly   837 -------QQIDSINSQL-------DFEKQKDTKKNVERWERSVQDEEDALEGLKLAEARYLKEID 887
                   :.||.||:||       |.::.:.|               :|:...:.|:|.|...:|
 Worm   973 LEVGEDVKGIDIINAQLQTSTASIDAQRARYT---------------EAVAARREADAAYQTTVD 1022

  Fly   888 EDKEKMEKFKQDKQAKKQAVDDMEEDISKARKDVANLAKEIHNVGSHLSAVESKIEAKKNERQNI 952
                .....||......:.:||:|   :|...|.|.|               ..||:...:.:.:
 Worm  1023 ----NYNMVKQTYDELMRIIDDLE---NKTMADNAEL---------------DIIESAWMQPEKL 1065

  Fly   953 LLQAKTDCIVVPLLRGSLDDAVRQSDPDVPSTSAAME-----------NIIEVDYSSLPREYTKL 1006
            ....|               .||.:|||:   :|.|.           ::||....:......::
 Worm  1066 YPPGK---------------FVRYNDPDI---AAKMTDGHVVLPYECISMIEPHREAYEEHEARM 1112

  Fly  1007 KDDSAFKKTHEMLQKDLQSKLDVLERIQTPNMKALQKLDAVTEKVQSTNEEFENARKKAKRAKAA 1071
            .:|..|:.|...:.| |:..:|...| :..| |.::....:...:.:   |..:|:|.:.:.||.
 Worm  1113 LEDDVFEDTANKICK-LEKDVDKFRR-EFDN-KGVRDYAMIVSLLMN---EVTSAKKFSDKLKAH 1171

  Fly  1072 FERVKNERSSRFVACCQHISDAI-------DGIYKKLAR-NEAAQAYIGPDNPEEPYLDGINYNC 1128
            .|::...|.:||    ...|:|:       ..:|:.:.. .:|:..::......:|:..||.::
 Worm  1172 REKLNELRMARF----NEFSEALAFLGTTTQMLYQLITNGGDASLKFVEEGKSTDPFDGGIKFS- 1231

  Fly  1129 VAPGKR-FQPMNNLSGGEKTIAALALLFSTHSFHPAPFFVLDEIDAALDNTNIGKVASYIR--DH 1190
            |.|.|: ::.:.||||||||:|:|..:|:.|.:.|.|.:|:||||||||..|:..:|:||:  :.
 Worm  1232 VRPAKKSWKLIENLSGGEKTLASLCFVFAMHHYRPTPLYVMDEIDAALDLNNVSLIANYIKHSER 1296

  Fly  1191 TTNLQTIVISLKEEFYGHADALVGITPGEG 1220
            |.|.|.|:|||:.:.:...:.|:||...:|
 Worm  1297 TRNAQFIIISLRNQMFEVGNRLLGIYKIDG 1326

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC1	NP_651211.2	Smc	26..1216	CDD:224117	331/1380 (24%)
		ABC_SMC1_euk	27..>171	CDD:213242	55/165 (33%)
		SMC_hinge	535..653	CDD:214944	31/127 (24%)
		DUF4700	<697..>810	CDD:292399	29/140 (21%)
		ABC_SMC1_euk	<1130..1232	CDD:213242	40/94 (43%)
dpy-27	NP_497771.1	Smc	91..1322	CDD:224117	331/1381 (24%)
		P-loop_NTPase	91..>247	CDD:304359	54/160 (34%)
		SMC_hinge	620..736	CDD:284001	31/132 (23%)
		P-loop_NTPase	<1235..1331	CDD:304359	39/92 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D326079at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820