Protein Alignment SMC1 and smc-6

DIOPT Version :9

• Sequence 1: NP_651211.2
• Gene: SMC1 / 42853
• FlyBaseID: FBgn0040283
• Length: 1238
• Species: Drosophila melanogaster
• Sequence 2: NP_496476.2
• Gene: smc-6 / 174776
• WormBaseID: WBGene00010056
• Length: 1149
• Species: Caenorhabditis elegans
• Alignment Length: 1302
• Identity: 294/1302 - (22%)
• Similarity: 488/1302 - (37%)
• Gaps: 361/1302 - (27%)

  Fly     2 TEEDDDVAQRVATAPVRKPDDETAFLEYIEME-NFKSYRGH-IVVGPLKQFNAVIGPNGSGKSNF 64
            |.|...|:.|||:..:      |.|:.:..:: :||:.:.: ..:|         ||||||||..
 Worm    37 TGERIAVSGRVASVKL------TNFMCHANLQIDFKTAQNNCFYIG---------GPNGSGKSAL 86

  Fly    65 MDAISFVMGEKTSSLRVKRLNDLIHGSSI------GKPVSRSCYVTAKFVLNEERHMDFQRAVIG 123
            ..||:..:|.:.|.      ||  .|:::      |...|:.........||  .|.||...:
 Worm    87 FAAINLGLGGRGSD------ND--RGNTVKSYIKDGTTQSKITITLTNAGLN--AHPDFDDLI-- 139

  Fly   124 GSSEYRINGESVSSSTYLNKLEKIGINVKAKNFLVFQGAVENIAMKTPKERTALFEEISGSGLLK 188
             |.|..||   .:||||:.|..|:   ..:.|.      ||.|..:.                 |
 Worm   140 -SIERTIN---QASSTYIMKSVKV---TSSDNH------VERIVSRK-----------------K 174

  Fly   189 DDYNRLKQEMIVAEEETQF--TYQKKKGIAAERKEAKHEKMEADRYTRLQNEYNEKQVEYQLFRL 251
            .|.:|:.....:......|  :..:.:...|..|.|...|:..:. |.|:|           .||
 Worm   175 ADVDRIVSRFSIHLSNPAFWMSQDRSRSFLANFKPANVYKLYLES-TNLEN-----------IRL 227

  Fly   252 FHVERDIRKFTSDLEVRQQEVKAVEQRKEAADEILREKKKDAGKITRDLAKIDQEIREFETQMNK 316
            .::     :|...|:    |..|:.|.|  |.|||.|:||         .|..||.|:.:.::::
 Worm   228 SYI-----RFADALD----ECFALIQLK--AGEILNEQKK---------LKRMQEQRDLQAKLDQ 272

  Fly   317 RRPLYIKAKEKVTHCKKKLIS--LQKTLETAREADNAHQSDIRK--LEKQLADVEALKK--RFED 375
            .|.|......|:..||.:..:  ::.||: .:||....|.:.:|  .:.:.|..|..||  .|.|
 Worm   273 DRALVASFCWKLLFCKVRDYNDQIELTLK-KQEAQKTLQDETKKEYAKNRAARTEVEKKIQEFRD 336

  Fly   376 EIE---NESQRRGKSVNMEEGLVQEYDRLKQEAEATATQYRSELDSVNR-------------EQK 424
            |:|   .|.....:.::.::..|.|::...:|.|.:..:..||...:.|             |::
 Worm   337 EVEVQDAEIAEAREDLDAKKRKVLEFEEKIRECEQSIRKKTSEKKYMERTIVNAKNEVRILLEKQ 401

  Fly   425 SEQDTLDGETNRRASVEESFKKLTLQRE------EAVKRRDKLMDHIKSSQAALEEQNRIKDELR 483
            ..||.    |.|...||..:|.::.|||      |:.|.|:|| |.:.:.....||:   |..::
 Worm   402 GNQDL----TKRLTKVENDYKDISQQRENMELGGESAKLREKL-DTVITDYKRKEEE---KYTIQ 458

  Fly   484 RDVGTSKEKIAEKQRELEDVRDQLGDAKSDKHEDARRKKKQEVVELFKKQVPGVYDRMINMCQPT 548
            ||:...:.||   ::::|.:|......|     ||..|....:.|:..:         ||.   :
 Worm   459 RDINQLRRKI---EQDMETMRRSRATKK-----DAINKFGSHMAEILME---------INR---S 503

  Fly   549 HKRYNVAVTKVLGKFMEAIIVDTEKTARHCIQILKEQMLEVETFLPLDYLQVKPLK---ERLR-- 608
            ..|:.......|||::..|......|...||..|      ...||...:|..:.|:   :.||
 Worm   504 KSRFQTVPKGPLGKYITLIDPKWAFTVEECIGNL------ANNFLCSSHLDAEILRNIFQSLRIP 562

  Fly   609 ------------------NISDP-RNVRLVFDVLKFEPQEIERAVLFATGNALVCE--------- 645
                              |:.:| .:.:.::.||||...::...::..:.    ||
 Worm   563 AQDRPTIIVAKCNGRAYTNLHEPSSDFKSIYRVLKFSDPDVHNVIIDKSN----CEQFILIEDKT 623

  Fly   646 ----------TPEDAMKVAYEIDRSRFDALALDGTFYQKSGLISGGSH----------DLARKAK 690
                      .|::|:| ||.:|.|:..|...:..:...||   .|.|          |:
 Worm   624 EAMELMGSNYPPQNAVK-AYTLDGSQAYANGPNSQYRFYSG---RGGHARGTFGNDQGDV----- 679

  Fly   691 RWDEKHMAQLKMQKERLQEELKELVKKSRKQSELATVESQ-IKGLENRLKYSMVDLESSKKSISQ 754
              ||..:|       ||.|:.|         ||...:|:| ::..::.||....:.:.:|.:|.:
 Worm   680 --DEGALA-------RLIEDTK---------SEAMRLETQDLRKQDHELKVIYNERDQTKAAIDE 726

  Fly   755 YDNQLQQVQSQLDEFGPKILEIERRMQNREEHIQEIKENMNNVEDKVYASFCRRLGVKNIRQYEE 819
            :|.:|..::||         |:::..|.::.. .|:.:..|  ||:          |:|:.:..|
 Worm   727 FDRKLSNLRSQ---------ELQKERQAKDLR-AELAQTAN--EDQ----------VENLNESIE 769

  Fly   820 RELVMQQERARKRAEFEQQIDSINSQLDFEKQKDTKKNVERWERSVQDEEDALEGLKLAEARYLK 884
                          |.:::|..|..::     ||..|||   .....|....::..|.|| ..|.
 Worm   770 --------------EMQKKIPLIEDEV-----KDILKNV---ADITADMAPVIQERKEAE-HTLA 811

  Fly   885 EIDEDKEKMEKFKQDKQAKKQAVDDMEEDISKARKDVANLAKEIHNVGSHLSAVESKIEAKKNER 949
            ||.::........|..|.:....||..| |.|.|.|   ..|....|..|   .|:|:   |:||
 Worm   812 EIQKETRDFASKSQKLQNELSKYDDAGE-ILKIRLD---KVKADEGVFFH---TEAKL---KSER 866

  Fly   950 QNILLQAKTDCIVVPLLRGSLDDAVRQSDPDV---PSTSAAMENIIE----VDYSSLPREYTKLK 1007
            .:.:...:.|....|:..|..|      .||:   |||:.|...|.|    ||.:::..:.|
 Worm   867 DDAMEMVENDKKNHPMPPGETD------PPDLSSFPSTTEAQRKIEEMQKAVDRATVGCDTT--- 922

  Fly  1008 DDSAFKKTHEMLQKDLQSKLDVLERIQTPNMKALQKLDAVTEKVQSTNEEFENARKKAKRAKAAF 1072
                  .|.|.: ||.:.||           |.|:.|..:.|.|....:....||.||..:...|
 Worm   923 ------ITLECV-KDFKDKL-----------KRLKYLCRMIEDVLIELKNLHAARVKAYPSLKKF 969

  Fly  1073 ERVK-NERSSRFVACCQHISDAIDGIYKKLARNEAAQ------AYIG--PDNPEEPYLDGINY-- 1126
            ..:| ..:....:|...|....::..::|...|...|      |..|  |:..|...:|..:|
 Worm   970 TELKVCNKFQELLAVRGHFIGGLEFDHEKETLNVNVQSSKEKDAMAGRRPEVLEVEEVDEHSYDD 1034

  Fly  1127 ---NCVAP-----------GKRFQPMNNLSGGEKTIAALALLFSTHSFHPAPFFVLDEIDAALDN 1177
               :...|           .||.:.:..|||||::....||:.|.......||.::||.|..:|.
 Worm  1035 DSDDSTGPRRKKSKKSGQKKKRVRDLKGLSGGERSFVTAALVMSLWEVMEQPFRMMDEFDVFMDM 1099

  Fly  1178 TN 1179
            .|
 Worm  1100 MN 1101

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC1	NP_651211.2	Smc	26..1216	CDD:224117	287/1278 (22%)
		ABC_SMC1_euk	27..>171	CDD:213242	39/151 (26%)
		SMC_hinge	535..653	CDD:214944	27/160 (17%)
		DUF4700	<697..>810	CDD:292399	23/113 (20%)
		ABC_SMC1_euk	<1130..1232	CDD:213242	18/61 (30%)
smc-6	NP_496476.2	SMC_N	75..1128	CDD:330553	284/1258 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900