Protein Alignment SMC1 and mix-1

DIOPT Version :9

• Sequence 1: NP_651211.2
• Gene: SMC1 / 42853
• FlyBaseID: FBgn0040283
• Length: 1238
• Species: Drosophila melanogaster
• Sequence 2: NP_496331.1
• Gene: mix-1 / 174669
• WormBaseID: WBGene00003367
• Length: 1244
• Species: Caenorhabditis elegans
• Alignment Length: 1328
• Identity: 287/1328 - (21%)
• Similarity: 563/1328 - (42%)
• Gaps: 279/1328 - (21%)

  Fly    27 LEYIEMENFKSYRGHI-VVGPLKQFNAVIGPNGSGKSNFMDAISFVMG-EKTSSLRVKRLNDLI- 88
            ::.|.::.||||:.|. ::.....|||:.|.|||||||.:|:|.|:|| .|..::|.|.:::||
 Worm     3 IKSIHLDGFKSYQKHTDILDFSPTFNAITGYNGSGKSNILDSICFIMGINKLDNIRAKSMHELIS 67

  Fly    89 HGSSIGKPVSRSCYVTAKFVLNEER-------HMD---FQRAVI------GGSSEYRINGESVSS 137
            ||.:       ...|..:|...::|       |:|   .||.:.      |.::.|.:||.:.::
 Worm    68 HGGT-------KAIVQVRFDNTDKRCSPFGMEHLDEIVVQRIITAQATGKGCATSYTLNGHAATN 125

  Fly   138 STYLNKLEKIGINVKAKNFLVFQGAVENIAMKTPKERTALFEEISGSGLLKDDYNRLKQEMIVAE 202
            ....:....:|:||...:||:.||.:..:....|:|...:.||.:|:.:    |::.|::    .
 Worm   126 GKMQDFFRGVGLNVNNPHFLIMQGRITTVLNMKPEEILGMVEEAAGTKM----YDQKKKD----A 182

  Fly   203 EETQFTYQKK-KGI-----------AAERKEAKHEKMEADRYTRLQNEYNEKQVEYQLFRLFHVE 255
            |:|.|....| |.:           ..:.:|.:...:|..|..:|:..::.|   |:.|:.|...
 Worm   183 EKTMFLKDAKLKEVDRIFQSSIDPRMVKFREDRKNMVEVTRLKKLKENFSRK---YEAFQYFQTC 244

  Fly   256 RDIRKFTSDLEVRQQEVKAVEQRKEAADEILREKKKDAGKITRDLAKIDQEIREFETQMNKRRPL 320
            ..::|...::|..::.::.:.::....|..|:.|:.:..|:        :|.|:.:.:
 Worm   245 EAVKKSAKEIEDAKKGIEDLGEKFNQLDLDLKNKEDEKKKM--------EESRDDQHE------- 294

  Fly   321 YIKAKEKVTHCKKKLISLQK------TLETAREADNAHQSDIRKLEKQLADVEALKKRFEDEIEN 379
              :|.....|..|:.|.|||      .:||..:.....:...:.|.|....::|.:|..||
 Worm   295 --EAALSAAHLSKQSIMLQKETVKNQLVETINKLKKEGEQINKSLSKDREVLDAKRKEHED---- 353

  Fly   380 ESQRRGKSVNMEEGLVQEYDRLKQEAEATATQYRSELDSVNREQKSEQDTLDGETNRRASVE--- 441
                 .|:.|.::...|..|      ||..|:||::|:|:.|      .|:..:.....|:|
 Worm   354 -----SKAANSKDIQSQSDD------EALVTKYRNDLESLTR------GTIANDKGEHVSIESEI 401

  Fly   442 ESFKKLTLQREEAV----KRRDKL---MDHIKSSQAALEEQNRIKDELRRDVGTSKEKIAEKQRE 499
            :|.|....|....:    ||.::|   :.|::..:|.|..::      :.|:|::.    ..|:|
 Worm   402 QSCKSTASQMSSGITAAKKRGERLHNQIKHLEGEKATLSARS------KSDIGSAD----NYQKE 456

  Fly   500 LEDVRDQLG------DAKSDK-------HEDARRKKKQEV---------------------VELF 530
            ::::..||.      ||.::|       ||...:.|..:.                     ::.|
 Worm   457 VDEINKQLQLLGFNIDADTEKREHAAKLHESITKLKDMDTRLLNSYKDGRYALNYQRPPLHIDKF 521

  Fly   531 --KKQVPGVYDRMINMCQPTHKRYNVAVTKVLGKFMEAIIVDTEKTARHCIQILKEQMLEVETFL 593
              |:.|.|....:|.| :|..:::.||....||..:..::|.|:..||  |.|..:.....:|.:
 Worm   522 DEKRDVFGYVAHLIKM-KPGCEQFAVAADIALGGVLGNVVVSTQDIAR--ILIDGKAFTSRKTMI 583

  Fly   594 PL--------DYLQVKPLK-ERLRNISDPRN--VRLVFDVLKFEPQEIERAVLFATGNALVCETP 647
            |:        .|..:..:| .|.:.|::..|  |..:.|:::: |..|...:|.|.|..||.::.
 Worm   584 PVSENARNASSYNTLPDVKLRRAKEIAEKYNDTVTKMIDLIEY-PDFISNTILNAVGQILVVDSL 647

  Fly   648 EDAMKVAY-EIDRSRFDALALDGTFYQKSGLISGGSHDLARKAKRWDEKHMAQLKMQKERLQEEL 711
            :.|.::|| |:.::|.  :...|...:.:|:::||.:|...|......:.|...:.|.|..|.||
 Worm   648 DVAREIAYDEVAKTRM--ITRRGDDVRTNGIMTGGYNDPGNKPALIALEPMYARRPQIEAQQREL 710

  Fly   712 KELVKKSRKQSELATVESQ-IKGLENRLKYSMVDLESSKKSISQYDNQLQQVQSQLDEFGPKILE 775
            ..|    .::.:|....|| .:.|.|:|..:|..|...|.:|:.            .|||..:.:
 Worm   711 DAL----NRELQLTEASSQKCRDLNNQLATAMRKLAQVKTNINN------------SEFGIVVRD 759

  Fly   776 IERRMQNREEHIQEIK---ENMNNVEDKVYASFCRRLGVKNIRQYEERELVMQQERARKRAEFEQ 837
            ::...:..|::..||:   :.:.:||||          :|.:...:.::...|::|.::.....|
 Worm   760 LKVHSEEYEKNQAEIEATVKTLKDVEDK----------IKTLESMKNKDKNSQEKRKKELTALLQ 814

  Fly   838 QIDSINSQLDFEKQKDTKK------NVERWERSVQDEEDALEGLKLAEARYLKEIDEDKEK---- 892
            :.:...:|.....:|..::      .||..|::::.:|...|..|       ||.||.:||
 Worm   815 KAEQTVAQNKNRGEKARREVMLLQATVEEMEKTIKKDEGIWEQKK-------KECDELEEKLPNA 872

  Fly   893 ---MEKFKQDKQAKKQAVDDMEEDISKARKDVANLAKEIHNVGSHLSAVESKIEAKKNERQNILL 954
               ::..:.:::|.:..::|::.:..:....:..:|||.    ..|...::|.::|:.|::..|
 Worm   873 IAALKDAELEQKAAQAKLNDLKNNQRQISTRLGKIAKEC----DALIREKAKTKSKREEKEKEL- 932

  Fly   955 QAKTDCIVVPLLRGSLDDAVRQSDPDVPSTSAAMENIIEVDYSSLPREYTKLKDDSA-FKKTHEM 1018
                             .:::||  :..:...|...:         :::..|.|:.| |.|...:
 Worm   933 -----------------TSLQQS--EASNRKEARSKL---------KKFEWLSDEEAHFNKKGGL 969

  Fly  1019 LQ-------------KDLQSKLDVLER---IQTPNMKALQKLDAVTEKVQSTNEEFENARKKAKR 1067
            ..             |:|..|::.|||   ||.     :..||....||.....:.|...:....
 Worm   970 YDFEGYTVSKGKDEIKELTDKIETLERSCCIQN-----VSNLDTCEAKVLDIKNKRERITEDFNM 1029

  Fly  1068 AKAAFERVKNERSSRFVACCQHISDAIDGIYKKLARNEAAQAYIGPDNPE-EPYLDGINYNCVAP 1131
            .|.....:..::....:...:.::.....|:..|..:  |.|.:.|  || :...:|:.......
 Worm  1030 LKKTIATLDKKKVDELIRAHESVNKDFGQIFNCLLPD--AHASLVP--PEGKTVCEGLEVKVSFG 1090

  Fly  1132 GKRFQPMNNLSGGEKTIAALALLFSTHSFHPAPFFVLDEIDAALDNTNIGKVASYIRDHTTNLQT 1196
            |.....::.||||::::.||:|:.:...|.|||.::|||:|||||.::...:...|:.|..:.|.
 Worm  1091 GVVKDSLHELSGGQRSLVALSLILAMLKFKPAPLYILDEVDAALDLSHTANIGMMIKTHFHHNQF 1155

  Fly  1197 IVISLKEEFYGHADAL--VGITPGEGDC 1222
            |::|||:..:.:||.|  .....|...|
 Worm  1156 IIVSLKQGMFSNADVLFQTRFADGHSTC 1183

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC1	NP_651211.2	Smc	26..1216	CDD:224117	285/1320 (22%)
		ABC_SMC1_euk	27..>171	CDD:213242	47/162 (29%)
		SMC_hinge	535..653	CDD:214944	31/128 (24%)
		DUF4700	<697..>810	CDD:292399	27/116 (23%)
		ABC_SMC1_euk	<1130..1232	CDD:213242	32/95 (34%)
mix-1	NP_496331.1	Smc	1..1172	CDD:224117	284/1315 (22%)
		ABC_SMC2_euk	1..>157	CDD:213240	47/160 (29%)
		SMC_hinge	527..654	CDD:284001	32/130 (25%)
		TMPIT	765..>854	CDD:285135	17/98 (17%)
		P-loop_NTPase	<1086..1184	CDD:304359	32/98 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810