Protein Alignment SMC1 and smc-5

DIOPT Version :10

• Sequence 1: NP_651211.2
• Gene: SMC1 / 42853
• FlyBaseID: FBgn0040283
• Length: 1238
• Species: Drosophila melanogaster
• Sequence 2: NP_494935.1
• Gene: smc-5 / 173874
• WormBaseID: WBGene00016151
• Length: 1076
• Species: Caenorhabditis elegans
• Alignment Length: 1286
• Identity: 257/1286 - (19%)
• Similarity: 463/1286 - (36%)
• Gaps: 384/1286 - (29%)

  Fly     1 MTEEDDDVAQRVATAPVRKPDDETAFLEYIEMENFKSYRGHIVVGPLKQFNAVIGPNGSGKSNFM 65
            |..:|.|.|     .|....|.....|..:...||.:|. |....|....|.::|.||||||:.:
 Worm     1 MASQDSDEA-----LPANYKDYPDGSLLRVVFHNFLTYE-HTSFLPTASLNMILGHNGSGKSSII 59

  Fly    66 DAISFVMGEKTSSL-RVKRLNDLI-HGSSIGKPVSRSCYVTAKFVLNEERHMDFQRAVI--GGSS 126
            ..|....|....|| |.:|:.:.| ||.:.|       ||... :.::::.....|..|  |...
 Worm    60 CGICLACGGSPKSLGRSERIVEYIRHGCTEG-------YVEIA-IADKQKGPQVVRLTIRVGEQP 116

  Fly   127 EYRINGESVSSSTYLNKLEKIGINVKAKNFLVFQGAVENIAMKTPKERTALFEEISGSGLLKDDY 191
            :||:| :|.::.:.:..|.| ..|::..|...|          ..:::...|.|.|...||::
 Worm   117 KYRLN-DSATTQSEIADLRK-HYNIQIDNPCAF----------LAQDKVKSFSEQSSIELLRN-- 167

  Fly   192 NRLKQEMIVAEEETQFTYQKKKGIAAERKEAKHEKMEADRYTRLQNEYNEKQVEYQLFRLFHVER 256
                               .:|..:|:..:.                              |:
 Worm   168 -------------------TEKAASADLDQQ------------------------------HI-- 181

  Fly   257 DIRKFTSDLEVRQQEVKAVEQRKEAADEILREKKKDAGKITRDLAKIDQEIREFETQMNKRRPLY 321
                   ||..::::..::|.:...::..::..:.:.|||   :..::          |.|:.|.
 Worm   182 -------DLMKQREDSTSIEDKCTTSENAIKRLEDEIGKI---MPLVE----------NYRKKLA 226

  Fly   322 IKAKEKVTHCKKKLISLQK-TLETAREADNAHQS--DIRKLEKQLADVEALKKRFEDEIENESQR 383
            :::|.::...|.|::..:| ..|...|..|...:  :.|::||.:|:.|..:|..||.|:.:
 Worm   227 LQSKLRLLEKKMKIMEFEKFDREYKAELQNMDGAMIEYREVEKSIAECEKHRKNLEDRIKKD--- 288

  Fly   384 RGKSVNMEEGLVQEYDRLKQEAEATATQYRSELDSVNR---------EQKSEQDTLDGETNRRAS 439
                                         ||::..:.|         ::|.::..::....|..:
 Worm   289 -----------------------------RSQISQMQRSCNEILAKVQEKGDKKLMEDMMQRAKA 324

  Fly   440 VEESFKKLTLQREEAVKRRDKLMDHIKSS-QAALEEQNRIKDELRRDVGTSKEKIAEKQRELEDV 503
            ..||.||...|.|:.|::..|::|..::. |.|::..|.. :|.:.::.:.::|.:..:|:
 Worm   325 KLESAKKAADQHEKDVEKARKMIDQARARLQEAVDTLNGY-EEFQSEMKSLEQKYSTAERD---- 384

  Fly   504 RDQLGDAKSDKHEDARRKKKQEVVELFKKQVPGVYDRMINMCQPTHKRYNVAVTKVLGKFMEAII 568
                    |.:.|||.:||..|:.:|..|:.....:..:|    ...||     :||..|..
 Worm   385 --------SRQEEDAIQKKSYEMRQLENKKRDEEQNSQLN----RQDRY-----RVLQNFSS--- 429

  Fly   569 VDTEKTARHCIQILKEQMLEVETFLPLDYLQVKPLKERLRNISDPRNVRLVFDVLKFEPQEIERA 633
             |..|..|...|  .....:.:.::|                        :.|
 Worm   430 -DASKAYRWYQQ--NRSQFKGDVYMP------------------------IMD------------ 455

  Fly   634 VLFATGNALVCETPEDAMKVAYEI---DRSRFDALALDGTFYQKSGLISGGSH------DLARKA 689
                    :|.:|||.|..:...:   ||:.|..     .:.:...||:|..|      .:....
 Worm   456 --------MVLKTPEAAKALENSVGVRDRTMFVC-----CYKEDELLINGKQHSWRINTSVVPAE 507

  Fly   690 KRWDEKHMAQLKMQKERLQEELKELVKKS-RKQSELATVESQIKGLENRLKYSMVDLESSKKSIS 753
            |.:.|...|||..:..||  ..|.||... ...:.|......:.|| ||:.:...|:|.....:|
 Worm   508 KIYSEDIDAQLPSELSRL--GFKYLVSNCFDAPAPLKQFLCNVSGL-NRIPFGGSDVEKKIAEVS 569

  Fly   754 Q-----------------------YDNQLQQVQSQL-------DEFGPKILEIERRMQNR-EEHI 787
            |                       |.|...|.||..       |:|. |:..:.:|..|. .|.|
 Worm   570 QAIEQTRYSVFLTANIRCQNSKSRYANNTLQSQSATREANTWRDQFF-KVSPVAKRTDNSILEEI 633

  Fly   788 QEIKENMNNVEDKVYASFCRRLGVKNIRQYEERELVMQQERARKRAEFEQQIDSINSQLDFEKQK 852
            |::|..:                  :||..:.||         ||...:::.|.:..:   :.|.
 Worm   634 QKLKAEI------------------DIRSEQLRE---------KRGAIQKERDVLRQE---QMQW 668

  Fly   853 DTKKNVE-RWERSVQDEEDALEGLKLAEARYLKEIDEDKEKMEKFKQDKQAK----------KQA 906
            .:||.|. :|:..:..|...||.|: .|...:..|:|:...:|| |...:.|          |:.
 Worm   669 KSKKQVHTKWKTELASEMAKLEALE-NEVVDISAIEEEYANVEK-KAILETKKMLENSIRWHKEI 731

  Fly   907 VD--------DMEEDISKARKDVANLAKEIH-----NVGSHLSAVESKIEAKKNERQNILLQAKT 958
            :|        ::.|.|.|:|.:.:|...|.|     ::.|...|.|..::...|.::........
 Worm   732 IDKHRLIGIFELSESICKSRVNKSNSEAETHRSKLEDLKSVKDAAEDLLKTALNHKKAAASALMK 796

  Fly   959 DCIVVPLLRGSLDDAVRQ---------SDPDVPSTSAAMENIIEVDYSSLPREYTKLKDDSAFKK 1014
            :|.:..|....:..|..:         .:.|||:....::..|..:.:.|     ||.:||....
 Worm   797 ECSLKTLDESKMSPAENKIYSSLVKMFEEADVPTDMNTLDQAITSEKTRL-----KLAEDSGEDG 856

  Fly  1015 T--HEMLQKDLQSKLDVLERIQTPNMKALQKLDAVTEKVQSTNEEFENARKKAKRAKAAFERVKN 1077
            :  ||...|.|...| |||:  |...|.::....:.:|:   .:|..|.||:   .:...|:: |
 Worm   857 SIVHEQRLKVLDDDL-VLEK--TRQEKLIENRARIHDKL---GDEINNWRKE---VETMIEQI-N 911

  Fly  1078 ERSSRF---VACCQHISDAIDGIYKKLARNEAAQAYIGPDNPEEPYLDGINYN-----CVAPGKR 1134
            ....:|   :.|...:|..:                  |:||    ||...|.     |...|:.
 Worm   912 VNYVQFFDSLGCRGEVSLEV------------------PENP----LDIEKYGIMIMVCFRKGES 954

  Fly  1135 FQPMNN--LSGGEKTIAALALLFSTHSFHPAPFFVLDEIDAALDNTNIGKV 1183
            .:.::|  .||||:::|.:..|.:.....|.||..:|||:..:|.||..||
 Worm   955 MKRLDNKVQSGGERSVATMLYLLALQQLCPVPFRCIDEINQGMDPTNERKV 1005

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC1	NP_651211.2	SMC_N	26..1222	CDD:481474	251/1261 (20%)
smc-5	NP_494935.1	P-loop containing Nucleoside Triphosphate Hydrolases	20..>180	CDD:476819	45/231 (19%)
		SMC_prok_B	165..1001	CDD:274008	205/1090 (19%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<947..1052	CDD:476819	20/59 (34%)