DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SMC1 and him-1

DIOPT Version :9

Sequence 1:NP_651211.2 Gene:SMC1 / 42853 FlyBaseID:FBgn0040283 Length:1238 Species:Drosophila melanogaster
Sequence 2:NP_001040658.2 Gene:him-1 / 172116 WormBaseID:WBGene00001860 Length:1262 Species:Caenorhabditis elegans


Alignment Length:1246 Identity:496/1246 - (39%)
Similarity:753/1246 - (60%) Gaps:53/1246 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 LEYIEMENFKSYRGHIVVGPLKQFNAVIGPNGSGKSNFMDAISFVMGEKTSSLRVKRLNDLIHGS 91
            |..:|:||||||:|...:||..:|.|:||||||||||.|||||||:|||.|||||::..|||||:
 Worm    16 LHTLEIENFKSYKGKHTIGPFTRFTAIIGPNGSGKSNLMDAISFVLGEKPSSLRVRKYADLIHGA 80

  Fly    92 SIGKPVSRSCYVTAKFVLNEERHMDFQRAVIGGSSEYRINGESVSSSTYLNKLEKIGINVKAKNF 156
            .|.|||::.|.||..:..::.:...|.|.|..|:||:.::|::|:|:.|..::|.|.|.:||:||
 Worm    81 PINKPVAKKCRVTMNYKYSDGKVKAFTRGVNNGTSEHLLDGQTVTSAAYSQEMESINIFIKARNF 145

  Fly   157 LVFQGAVENIAMKTPKERTALFEEISGSGLLKDDYNRLKQEMIVAEEETQFTYQKKKGIAAERKE 221
            ||:|||:||||||||||||.||||:|.|...:.:|.|||.||..||::||....|::|||.|::|
 Worm   146 LVYQGAIENIAMKTPKERTQLFEELSRSHEFQAEYERLKVEMTKAEDDTQHNMNKRRGIAQEKRE 210

  Fly   222 AKHEKMEADRYTRLQNEYNEKQVEYQLFRLFHVERDIRKFTSDLEVRQQEVKAVEQRKEAADEIL 286
            ||.||.||::|..::||...|.....|.:|||.||.|.:...::..:::.:.::|..:...:..:
 Worm   211 AKMEKDEAEKYQTMKNELAAKSTMLFLHQLFHCERTIDESKEEINAQKKTIASLEATRSKEEAKI 275

  Fly   287 REKKKDAGKITRDLAKIDQEIREFETQMNKRRPLYIKAKEKVTHCKKKLISLQKTL---ETAREA 348
            ....::..|..|::.|:.:::.:.||.:.:::...:..|..|.|..|||...:|.|   |:..|.
 Worm   276 AAVHQEHRKALREVQKMTRKLDQKETDLAEKQQNMLTLKVSVAHEHKKLEIAKKMLAAAESKAEN 340

  Fly   349 DNAHQSDIRKLEKQLADVEALKKRFEDEIENESQRRGKSVNMEEGLVQEYDRLKQEAEATATQYR 413
            ::...:|::|.:|:|   |..|..:|.||::..||  ..:|:.:..|:||.:||.:|:..:...:
 Worm   341 NSTQLADLKKSKKEL---EKKKAAYEAEIQDMMQR--GELNLSDEQVREYGQLKDQAQRESAMVQ 400

  Fly   414 SELDSVNREQKSEQDTLDGETNRRASVEESFKKLTLQREEAVKRRD----KLMDHIKSSQAALEE 474
            .||....:..:.::.:|:.|..|:...:|..|    .:|..|:|.:    .|...||.::   ||
 Worm   401 RELLMAEQVFEGDKSSLNHELRRQKEHQERVK----AKEGDVRRIETQIATLAQRIKETE---EE 458

  Fly   475 QNRIKDELRR---DVGTSKEKIAEKQRELEDVRDQLGDAKSDKHEDARRKKKQEVVELFKKQVP- 535
            ...:|.:|::   ||...|...||..:||..|..||.:|..|..|..|.:::.|.:|..||..| 
 Worm   459 TKILKADLKKIENDVVIDKSAAAEYNKELVAVVRQLSEASGDSAEGERNQRRTEALEGLKKNFPE 523

  Fly   536 GVYDRMINMCQPTHKRYNVAVTKVLGKFMEAIIVDTEKTARHCIQILKEQMLEVETFLPLDYLQV 600
            .||.|::::|||:|||:|:|.||:|.|.|.:|:.|||:||...|..||:.....|||||.|.|.|
 Worm   524 SVYGRLVDLCQPSHKRFNIATTKILQKHMNSIVCDTEETAAKAIVYLKDHRYPPETFLPNDALVV 588

  Fly   601 KPLKERLRNISDPRNVRLVFDVLKFEPQEIERAVLFATGNALVCETPEDAMKVAY---EIDRSRF 662
            .||.|:||.|..|..|:|||||:..:.|...:|:.|..|||||||:.|||.::||   |: :.||
 Worm   589 NPLNEKLREIKKPAGVKLVFDVINPQHQAARKALQFVCGNALVCESQEDAKQLAYGGGEL-KDRF 652

  Fly   663 DALALDGTFYQKSGLISGGSHDLARKAKRWDEKHMAQLKMQKERLQEELKELVKKSRKQSELATV 727
            .|:::|||.:|:||::||||.||.:|:|:||||.:.||:.::.:|.|::.:|.|..|::.|:.:|
 Worm   653 KAVSMDGTLFQQSGVMSGGSADLRQKSKKWDEKVVKQLREKRNQLNEKIADLQKHRRRELEVESV 717

  Fly   728 ESQIKGLENRLKYSMVDLESSKK-SISQYDNQLQQVQSQLDEFGPKILEIERRMQNREEHIQEIK 791
            .|:|.|.|.||.....||::.:: .:.:..|:|:.:.::::...|:|...:.:::..|..::.::
 Worm   718 RSKINGNEQRLAMMKRDLKNMREMQLERLQNELEGMTAEMNMLPPRISNCQEKLERSESTLKSLQ 782

  Fly   792 ENMNNVEDKVYASFCRRLGVKNIRQYEERELVMQQERARKRAEFEQQIDSINSQLDFEKQKDTKK 856
            ...|.|.|:::|.||.|:|:.:||.||.||:.::||...|...|:..|..:..::||..::|..:
 Worm   783 TKSNEVADRIFADFCTRVGIASIRDYENREMRIKQEMEDKLRSFDDDIQKLAYEIDFVTEQDGNR 847

  Fly   857 NVERWERSVQDEEDALEGLKLAEARYLKEIDEDKEKMEKFKQDKQAKKQAVDDMEEDISKARKDV 921
            .||..:..|...:...:.:|..|......:.|..|.||:.|:..:.||.....:|.:.::.:| :
 Worm   848 KVEVEKEKVSQIDRQYKDMKKKEKTAAAALKEHTESMEQDKEVLEEKKALSHKLETEWNEVKK-I 911

  Fly   922 ANLA-KEIHNVGSHLSAVESKIEAKKNERQNILLQAKTDCIVVPLLRGSL----------DDAVR 975
            |.:| |:.......|..:||.:..|:.||.::|...|...|.:||..||:          ||...
 Worm   912 AQVAMKDFTKAEKELLRLESLLTKKQYERHSLLHSVKLGQIALPLKSGSMADVEYEEDDGDDTAS 976

  Fly   976 QSD------PDVPSTSAAMENIIEVDYSSLPREYTKLKDDSAFKKTHEMLQKDLQSKLDVLERIQ 1034
            ||.      |.|.......|..|:::|.||||||..:.||...::....|..::......:.::.
 Worm   977 QSSQSATDGPSVSEEQIQREQHIKINYDSLPREYKDVDDDDGVRQMSNRLNVEIDELQKNVSKMN 1041

  Fly  1035 TPNMKALQKLDAVTEKVQSTNEEFENARKKAKRAKAAFERVKNERSSRFVACCQHISDAIDGIYK 1099
            .||:||.|::..|.|:...:.||.|||||||||.:..||:||.:|..||......:::.||.|||
 Worm  1042 APNLKANQRMAEVKEREAESTEELENARKKAKRIRQQFEKVKTDRYRRFQDFFDPVANTIDDIYK 1106

  Fly  1100 KLARNEAAQAYIGPDNPEEPYLDGINYNCVAPGKRFQPMNNLSGGEKTIAALALLFSTHSFHPAP 1164
            :|:||.:|||::|.||.||||||||.||||||||||:||:||||||||||||||||:.|..:|||
 Worm  1107 QLSRNTSAQAFLGADNMEEPYLDGIQYNCVAPGKRFRPMDNLSGGEKTIAALALLFAVHGRNPAP 1171

  Fly  1165 FFVLDEIDAALDNTNIGKVASYI----RDHTTNLQTIVISLKEEFYGHADALVGITPGEGDCLVS 1225
            |||||||||||||||||||||||    |:|   :|.||||||||||..||:|:||.|....|..|
 Worm  1172 FFVLDEIDAALDNTNIGKVASYICESAREH---MQIIVISLKEEFYNKADSLIGIFPYPAACTTS 1233

  Fly  1226 NVYIMDLTTFE 1236
            .|...|||.|:
 Worm  1234 GVLTFDLTRFK 1244

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SMC1NP_651211.2 Smc 26..1216 CDD:224117 487/1224 (40%)
ABC_SMC1_euk 27..>171 CDD:213242 78/143 (55%)
SMC_hinge 535..653 CDD:214944 60/118 (51%)
DUF4700 <697..>810 CDD:292399 29/113 (26%)
ABC_SMC1_euk <1130..1232 CDD:213242 73/105 (70%)
him-1NP_001040658.2 SMC_N 15..1232 CDD:280601 490/1232 (40%)
ABC_SMC1_euk 16..>160 CDD:213242 78/143 (55%)
Vps53_N 232..>334 CDD:282020 21/101 (21%)
SMC_hinge 523..641 CDD:214944 59/117 (50%)
ABC_SMC1_euk <1137..1240 CDD:213242 73/105 (70%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160167574
Domainoid 1 1.000 854 1.000 Domainoid score I19
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H4597
Inparanoid 1 1.050 868 1.000 Inparanoid score I209
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53603
OrthoDB 1 1.010 - - D326079at2759
OrthoFinder 1 1.000 - - FOG0001963
OrthoInspector 1 1.000 - - oto18192
orthoMCL 1 0.900 - - OOG6_101499
Panther 1 1.100 - - LDO PTHR18937
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1351
SonicParanoid 1 1.000 - - X1284
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1514.940

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