Protein Alignment SMC1 and Smc2

DIOPT Version :9

• Sequence 1: NP_651211.2
• Gene: SMC1 / 42853
• FlyBaseID: FBgn0040283
• Length: 1238
• Species: Drosophila melanogaster
• Sequence 2: NP_001288341.1
• Gene: Smc2 / 14211
• MGIID: 106067
• Length: 1191
• Species: Mus musculus
• Alignment Length: 1297
• Identity: 319/1297 - (24%)
• Similarity: 591/1297 - (45%)
• Gaps: 252/1297 - (19%)

  Fly    26 FLEYIEMENFKSYRGHIVVG---PLKQFNAVIGPNGSGKSNFMDAISFVMG-EKTSSLRVKRLND 86
            :::.|.:|.||||.....|.   ||  |||:.|.|||||||.:|:|.|::| ...|.:|...|.|
Mouse     2 YVKSIILEGFKSYAQRTEVNGFDPL--FNAITGLNGSGKSNILDSICFLLGISNLSQVRASNLQD 64

  Fly    87 LIHGSSIGKPVSRSCYVT------AKFVLNEERHMDF---QRAVIGGSSEYRINGESVSSSTYLN 142
            |::.:........|..:|      .:..|..|.|.:.   ::.||||.::|.|||.:.:::...:
Mouse    65 LVYKNGQAGITKASVSITFDNSDKKQSPLGFEAHDEITVTRQVVIGGRNKYLINGVNANNTRVQD 129

  Fly   143 KLEKIGINVKAKNFLVFQGAVENIAMKTPKERTALFEEISGSGLLKDDYNRLKQEMIVAEEETQF 207
            ....:|:||...:||:.||.:..:....|.|..::.||.:|:.:.  :|.::..:..:.::|.:.
Mouse   130 LFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAGTRMY--EYKKIAAQKTIEKKEAKL 192

  Fly   208 TYQKKKGIAAERKEAKHEKMEADRYTRLQNEYNEKQVEYQLFRLFHVERDIRKFTSDLEVRQQ-E 271
              ::.|.|..|......:|::.:|.:.|:.:...:::|: |.||:...:.:|  ..|.:.|.. |
Mouse   193 --KEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEH-LSRLYIAYQFLR--AEDTKERSAGE 252

  Fly   272 VKAVEQRKEAADEILREKKKDAGKITRDLAKIDQEIREFETQMNKRRPLYIKAKEKVTHCKKKLI 336
            :|.::.:.....|:|.|.:|       .:..::.||.|.|           :.|:|.|..|.|
Mouse   253 LKEMQDKIVNLQEVLSENEK-------KIKALNCEIEELE-----------RRKDKETGGKLK-- 297

  Fly   337 SLQKTLETAREADNAHQS--DIRKLEKQLADVEALKKRFEDEIENESQ---RRGKSV-NMEEGL- 394
            ||:.....|:..:...||  |::|  |.||..|..:|..::.:..:|:   .:.|.| .:.:||
Mouse   298 SLEDACAEAQRVNTKSQSAFDLKK--KNLASEETKRKELQNSMAEDSKALAAKEKEVKKITDGLH 360

  Fly   395 -VQEYDRLKQEAEATATQYRSELDSVNREQKSEQD----TLDGE--------TNRRASVEESFKK 446
             :||......||.|.|.|:   .::|:....|.:|    ||.|:        :..:...:::..|
Mouse   361 GLQEASNKDAEALAAAQQH---FNAVSAGLSSNEDGAEATLAGQMIACKNDISKAQTEAKQAQMK 422

  Fly   447 LTLQREEAVKRRD--KLMDH-IKSSQAALEEQNRIKDELRRDV------GTSKEKIAEKQREL-E 501
            |...::|...::.  |.||. .|..|.|.|...:.|::|..::      ...:||:.||.|:| .
Mouse   423 LKHAQQELKSKQAEVKKMDSGYKKDQDAFEAVKKAKEKLETEMKKLNYEENKEEKLLEKHRQLSR 487

  Fly   502 DVRDQLGDAKSDKHEDARRK-------KKQEVVELFKKQVPGVYDRMINMCQPTHKRYNVAVTKV 559
            |:.:..|     |||....|       .|.......:..|.|:...:||:   .......|:..|
Mouse   488 DINNLKG-----KHEALLAKFPNLQFAYKDPEKNWNRNSVKGLVASLINV---KDNSTATALEVV 544

  Fly   560 LGKFMEAIIVDTEKTARHCIQILKEQMLEVETFLPLDYLQVKPL-KERLR---NISDPRNVRLVF 620
            .|:.:..::||||.||:..::  |.::....|.:||:.:..:.: .|.||   |:..|.||.:..
Mouse   545 AGERLYNVVVDTEVTAKKLLE--KGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVAL 607

  Fly   621 DVLKFEPQEIERAVLFATGNALVCETPEDAMKVAYEIDRSRFDALALDGTFYQKSGLISGGSHDL 685
            .::.::| |:::.:.|..|...||...::|.|||:: .|.....:.|.|..:...|.:|||:...
Mouse   608 SLVDYKP-ELQKGMEFVFGTTFVCNNMDNAKKVAFD-KRIMTRTVTLGGDVFDPHGTLSGGARSQ 670

  Fly   686 ARKAKRWDEKHMAQLKMQKERLQEELKELVKKSRKQSELATVESQIKGLEN------------RL 738
            |...       :.:.:..|: :|:||:      .|::||..:|.::.||:|            .:
Mouse   671 AASI-------LTKFQEVKD-VQDELR------TKENELRALEEELAGLKNVAEKYRQLKQQWEM 721

  Fly   739 KYSMVDLESSKKSISQYDNQLQQVQSQLDEFGPKILEIERRMQNREEHIQEIKENMNNVEDKVYA 803
            |....||..:|...|.|..|    |.:||.....|.|.|..:::.:|..::.:|....:|:|
Mouse   722 KTEEGDLLQTKLQQSSYHKQ----QEELDALKKTIEESEETLKSTKEIQKKAEEKYEALENK--- 779

  Fly   804 SFCRRLGVKNIRQYEERELVMQQER-----------ARKRAEFEQQIDSINSQLDFEKQKDTKKN 857
                   :||.....|:||...|::           ::|..|.:|::::|..:|:         .
Mouse   780 -------MKNAEAEREKELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELE---------E 828

  Fly   858 VERWERSVQDEEDAL-EGLKLAEARYLK---EIDEDKEKMEKFKQDKQAKKQAVDDMEEDISKAR 918
            ::|...|.:.:.||: |.:|..|.:..|   |:.::||.:.| .||:..|::.:...:::|.|.:
Mouse   829 LKREHASNEQQLDAVNEAIKAYEGQIEKMAAEVAKNKESVNK-AQDELMKQKQIITAQDNIIKDK 892

  Fly   919 KDVANLAKEIHNVGSHLSAVESKIEAKKNERQNILLQAKTDCIVVPLLRGSLDDAVRQSDPDVPS 983
              .|.:||  ||:.::    ||:::.|:                       ||.::.:...:...
Mouse   893 --CAEVAK--HNLQNN----ESQLKIKE-----------------------LDHSISKHKREADD 926

  Fly   984 TSAAMENIIEVDYSSLPRE-YTKLKDDSAF-------KKTHEMLQKDLQSKLDVLERI-QTPNMK 1039
            .:|.:..::. ||..:..| :...:.:||:       |:..:.||| ||   :|.|:: :..|::
Mouse   927 AAAKVSKMLS-DYDWINAEKHLFGQPNSAYDFKTNNPKEAGQRLQK-LQ---EVKEKLGRNVNLR 986

  Fly  1040 ALQKLDAVTE-----------------KVQSTNEEFENARKKAKRAKAAFERVKNERSSRFVACC 1087
            |:..|....|                 |:.:|.|:.:  :||.:....|:::|..:..|.|
Mouse   987 AMNVLTEAEERYNDLMKKKRIVENDKSKILATIEDLD--QKKNQALNIAWQKVNKDFGSIF---- 1045

  Fly  1088 QHISDAIDGIYKKLARNEAAQAYIGPDNPE-EPYLDGINYNCVAPGKRF-QPMNNLSGGEKTIAA 1150
               |..:.|          |.|.:.|  || :..|||:.:. ||.|..: :.:..||||::::.|
Mouse  1046 ---STLLPG----------ANAMLAP--PEGQTVLDGLEFK-VALGNTWKENLTELSGGQRSLVA 1094

  Fly  1151 LALLFSTHSFHPAPFFVLDEIDAALDNTNIGKVASYIRDHTTNLQTIVISLKEEFYGHADAL 1212
            |:|:.|...|.|||.::|||:|||||.::...:...:|.|.|:.|.||:||||..:.:|:.|
Mouse  1095 LSLILSMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFTHSQFIVVSLKEGMFNNANVL 1156

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC1	NP_651211.2	Smc	26..1216	CDD:224117	319/1297 (25%)
		ABC_SMC1_euk	27..>171	CDD:213242	49/156 (31%)
		SMC_hinge	535..653	CDD:214944	30/121 (25%)
		DUF4700	<697..>810	CDD:292399	28/124 (23%)
		ABC_SMC1_euk	<1130..1232	CDD:213242	34/84 (40%)
Smc2	NP_001288341.1	Smc	1..1168	CDD:224117	319/1297 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810