DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SMC1 and Smc1b

DIOPT Version :9

Sequence 1:NP_651211.2 Gene:SMC1 / 42853 FlyBaseID:FBgn0040283 Length:1238 Species:Drosophila melanogaster
Sequence 2:NP_536718.1 Gene:Smc1b / 140557 MGIID:2154049 Length:1248 Species:Mus musculus


Alignment Length:1223 Identity:499/1223 - (40%)
Similarity:762/1223 - (62%) Gaps:16/1223 - (1%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 LEYIEMENFKSYRGHIVVGPLKQFNAVIGPNGSGKSNFMDAISFVMGEKTSSLRVKRLNDLIHGS 91
            ||.:.:|||||:||..|:||.|:|..:||||||||||.|||:||||||||::||||.:.:||||:
Mouse     4 LELLLVENFKSWRGRQVIGPFKRFTCIIGPNGSGKSNVMDALSFVMGEKTTNLRVKNIQELIHGA 68

  Fly    92 SIGKPVSRSCYVTAKFVLNEERHMDFQRAVIGGSSEYRINGESVSSSTYLNKLEKIGINVKAKNF 156
            ..|||||.|..||..::.:......|.|.:.||.|||....:.||.|.|:.:||.|||.|||:|.
Mouse    69 HTGKPVSSSASVTIIYIEDSGEEKTFTRIIRGGCSEYHFGDKPVSRSVYVAQLENIGIIVKAQNC 133

  Fly   157 LVFQGAVENIAMKTPKERTALFEEISGSGLLKDDYNRLKQEMIVAEEETQFTYQKKKGIAAERKE 221
            |||||.||:|:||.|||||..|||||.||....:|...|:::..|||:.||.:..||.:|||||.
Mouse   134 LVFQGTVESISMKKPKERTQFFEEISTSGEFIGEYEAKKKKLQKAEEDAQFHFNVKKNVAAERKH 198

  Fly   222 AKHEKMEADRYTRLQNEYNEKQVEYQLFRLFHVERDIRKFTSDLEVRQQEVKAVEQRKEAADEIL 286
            ||.||.||:.|..|..|....:::..||:|::.|..|....::||.....:..|:......:.|.
Mouse   199 AKIEKEEAEHYQNLLEELKINKIQLMLFQLYYNEEKINVLNTELEQMDGNLSVVKDTLSHHENIF 263

  Fly   287 REKKKDAGKITRDLAKIDQEIREFETQMNKRRPLYIKAKEKVTHCKKKLISLQKTLETAREADNA 351
            :.||||.|.:||.|.:..:|::..|..:|::||.||||||..:|..||| .|.|.|.|..|...:
Mouse   264 KAKKKDYGMLTRQLQQTAKELKSVEAILNQKRPQYIKAKENTSHHLKKL-DLSKKLITDNEKQCS 327

  Fly   352 HQSD-IRKLEKQLADVEALKKRFEDEIENESQRRGKSVNMEEGLVQEYDRLKQEAEATATQYRSE 415
            .|.| ||.|..:|||::...|.||.::|.:..::|:.:.:|...:..|..||::..........:
Mouse   328 KQEDGIRALVAELADLDRAWKSFEKQMEEKILQKGRDIELENSQLDRYKLLKEQVRRKVGIMTQQ 392

  Fly   416 LDSVNREQKSEQDTLDGETNRRASVEESFKKLTLQREEAVKRRDKLMDHIKSSQAALEEQNRIKD 480
            |:.:..|||:|::.|..|..|....:.:.|::..|.||..||.:||.::.|:....||::.:.::
Mouse   393 LEKLQWEQKAEKERLAFEKRRHGDTQGNLKQIKEQIEEHKKRIEKLEEYTKTCMDCLEDKKQQEE 457

  Fly   481 ELRRDVGTSKEKIAEKQRELEDVRDQLGDAKSDKHEDARRKKKQEVVELFKKQVP-GVYDRMINM 544
            .|::::..:|.:::|...||..:|::|.:|..|.||..|::|:.||:|..|:..| .|:.|::::
Mouse   458 ALKKEIENTKSRMSEVNEELSLIRNELQNAGIDNHEGKRQQKRAEVLEHLKRLYPDSVFGRLLDL 522

  Fly   545 CQPTHKRYNVAVTKVLGKFMEAIIVDTEKTARHCIQILKEQMLEVETFLPLDYLQVKPLKERLRN 609
            |.|.||:|.:||||:.|::|.||:|.:||.|:.||:.||.:..|.||||.||||.:||:.||||.
Mouse   523 CHPIHKKYQLAVTKLFGRYMVAIVVASEKIAKDCIRFLKAERAEPETFLALDYLDIKPINERLRE 587

  Fly   610 ISDPRNVRLVFDVLKFEPQEIERAVLFATGNALVCETPEDAMKVAYEIDRSRFDALALDGTFYQK 674
            |   :..:::.||:|.:..::::.:.|..||.|||||.|:|..:|:. ...|..|:|||||.:.|
Mouse   588 I---KGCKMMIDVIKTQFPQLKKVIQFVCGNGLVCETVEEARHIAFG-GPERRKAVALDGTLFLK 648

  Fly   675 SGLISGGSHDLARKAKRWDEKHMAQLKMQKERLQEELKELVKKSRKQSELATVESQIKGLENRLK 739
            ||:|||||.||..||..||||.:..|:.::.:|.:|||||:|..||:::|..:::.::|...|||
Mouse   649 SGVISGGSSDLKHKALCWDEKELHNLRDKRSQLVQELKELMKTLRKETDLKQIQTLVQGTNTRLK 713

  Fly   740 YSMVDLES-SKKSISQYDNQLQQVQSQLDEFGPKILEIERRMQNREEHIQEIKENMNNVEDKVYA 803
            ||..:||. .||.::.:..:..|:||:|.....:...:...:..:::.|:|.::.::.|||.::.
Mouse   714 YSQNELEMIKKKHLATFYREQSQLQSELLNIDSQCTMLSEGINKQQQKIEEFQDKIDEVEDDIFQ 778

  Fly   804 SFCRRLGVKNIRQYEERELVMQQERARKRAEFEQQIDSINSQLDFEKQKDTKK--NVERWERSVQ 866
            .||..:||:|||::|.:.:..|||..:||.|||:|...:|.||::.:.:..||  |::..:.::|
Mouse   779 DFCEEIGVENIREFENKHVKQQQENDQKRLEFEKQKTRLNIQLEYSRNQLKKKLNNIDTLKTTIQ 843

  Fly   867 DEEDALEGLKLAEARYLKEIDEDKEKMEKFKQDKQAKKQAVDDMEEDISKARKDVANLAKEIHNV 931
            ..::.::.||..|...||.::|...|.|:.|:....:...::.:...|.:.||.|..:.:|:..:
Mouse   844 KGKEDIDNLKKTEEECLKIVEELMVKQEQIKEVLATQSSNIEKIHIQIEEERKKVLAVDREVGKL 908

  Fly   932 GSHLSAVESKIEAKKNERQNILLQAKTDCIVVPLLRGSLDDAVRQSDPDVPSTSAA-----MENI 991
            ...:..::..:|.|..|:.|:||..|...|.:.|:.|||:|.:.....:..||.|.     .|..
Mouse   909 QKEVVIIQGSLEQKLLEKHNLLLDCKVQDIDISLVLGSLEDIIEMELTETESTQATADIYEKEAS 973

  Fly   992 IEVDYSSLPREYTKLKDDSAFKKTHEMLQKDLQSKLDVLERIQTPNMKALQKLDAVTEKVQSTNE 1056
            |::|||.|..:...|:.|...:....:|.:.:.|:.:.|.:...||::|.:.|..|.:|.|.:.:
Mouse   974 IQIDYSPLREDLKALQSDKEVEAHLTLLLQQVASQENTLLKTTAPNLRAQENLKTVRDKFQESAD 1038

  Fly  1057 EFENARKKAKRAKAAFERVKNERSSRFVACCQHISDAIDGIYKKLARNEAAQAYIGPDNPEEPYL 1121
            .||.:||:|:..:..||:||..|...|..|.:|||.:||.|||||.||.:|||::.|:|||||||
Mouse  1039 VFEASRKEARICRQEFEQVKRRRYDAFSQCFEHISVSIDQIYKKLCRNNSAQAFLSPENPEEPYL 1103

  Fly  1122 DGINYNCVAPGKRFQPMNNLSGGEKTIAALALLFSTHSFHPAPFFVLDEIDAALDNTNIGKVASY 1186
            |||:||||||||||.||:|||||||.:|||||||:.|||.|||||||||:||||||||||||:||
Mouse  1104 DGISYNCVAPGKRFMPMDNLSGGEKCVAALALLFAVHSFRPAPFFVLDEVDAALDNTNIGKVSSY 1168

  Fly  1187 IRDHT-TNLQTIVISLKEEFYGHADALVGITPGEGDCLVSNVYIMDLTTFEDT 1238
            |::.: ...|.|:||||||||..||||:|:.|...:|:.|:|..:||:.:.||
Mouse  1169 IKEQSQEQFQMIIISLKEEFYSKADALIGVYPEHNECMFSHVLTLDLSKYPDT 1221

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SMC1NP_651211.2 Smc 26..1216 CDD:224117 491/1199 (41%)
ABC_SMC1_euk 27..>171 CDD:213242 81/143 (57%)
SMC_hinge 535..653 CDD:214944 53/118 (45%)
DUF4700 <697..>810 CDD:292399 32/113 (28%)
ABC_SMC1_euk <1130..1232 CDD:213242 68/102 (67%)
Smc1bNP_536718.1 Smc 3..1199 CDD:224117 491/1199 (41%)
ABC_SMC1_euk 4..>148 CDD:213242 81/143 (57%)
DUF342 <421..492 CDD:302792 20/70 (29%)
SMC_hinge 513..628 CDD:214944 52/117 (44%)
ABC_SMC1_euk <1112..1215 CDD:213242 68/102 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1219..1248 2/3 (67%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 1151 1.000 Domainoid score I17
eggNOG 1 0.900 - - E1_COG1196
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1171 1.000 Inparanoid score I200
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53603
OrthoDB 1 1.010 - - D326079at2759
OrthoFinder 1 1.000 - - FOG0001963
OrthoInspector 1 1.000 - - otm43758
orthoMCL 1 0.900 - - OOG6_101499
Panther 1 1.100 - - O PTHR18937
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1284
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1312.840

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