Protein Alignment SMC1 and SelR

DIOPT Version :10

• Sequence 1: NP_651211.2
• Gene: SMC1 / 42853
• FlyBaseID: FBgn0040283
• Length: 1238
• Species: Drosophila melanogaster
• Sequence 2: XP_061501760.1
• Gene: SelR / 1272971
• VectorBaseID: AGAMI1_003951
• Length: 1342
• Species: Anopheles gambiae
• Alignment Length: 1247
• Identity: 262/1247 - (21%)
• Similarity: 473/1247 - (37%)
• Gaps: 362/1247 - (29%)

  Fly    30 IEMENFKSYRGHIVVGPLKQFNAVIGPNGSGKSNFMDAISFVMG-EKTSSLRVKRLNDLIHGSSI 93
            |.::||..:| |:||...|:.|.::|.||||||..:.|::..:| ....:.|...|.|||.....
Mosquito   299 IVLKNFMCHR-HMVVEFNKRANLLVGKNGSGKSAILAAMTIGLGCNAGQTNRCSSLKDLIKHGET 362

  Fly    94 GKPVSRSCYVTAKFVLNEERH---MDFQRAV-IGGSSEYRI---NGESVSSSTYLNKLEKIGINV 151
            ...:......||....:.||:   :..:|.: ..|...|::   :|::||:|.  .:|:||
Mosquito   363 QAVIEIHLENTAFNAYDPERYGGRIICERTLNASGGGSYKLKNEHGQTVSTSR--AELQKI---- 421

  Fly   152 KAKNFLVFQGAVENIAMKTPKERTALFEEISGSGLLKDDYNRLKQEMIVAEEETQFTYQKKKGIA 216
                .|.|     ||.:..|  ...|.::::.| ||||           ::|..|:|:..|....
Mosquito   422 ----LLAF-----NIQVDNP--ICVLNQDLARS-LLKD-----------SDESKQYTFFSKATQI 463

  Fly   217 AERKEAKHEKMEADRYTRLQNEYNEKQVEYQLFRLFHVERDIRKFTSDLEV--RQQEVKAVEQRK 279
            ...|:..:|.....:..|......||.:||....:..:|..    .|:||.  |..|:.:..|.|
Mosquito   464 DTIKQKLNECAVIAKKARDVLVVKEKSLEYLSNEIVVLEEK----QSNLESAGRMGELLSELQAK 524

  Fly   280 EAADEILREKKKDAGKITRDLAKIDQEIREFETQMNKRRPLYIKA-------KEKVTHCKKKLIS 337
            .|...:: ::::....:..:|.|:...|.|.|.::..|..|..|.       :..:...|::.::
Mosquito   525 LAWRNVI-DQEEQLAAVDDELKKLRTSIEEQEHRIRNREALVAKTDSTIDTYRADIESKKQEYVA 588

  Fly   338 LQKTLETAREADNAHQSDIRKLEKQLADVEALKKRFEDEIENESQRRGKSVNMEEGLVQEYDRLK 402
            |::...|.|              :.|.||:|.:...|..:.|.|:|              ..|::
Mosquito   589 LKEAYGTVR--------------RTLQDVQAKQAAIERGMRNASER--------------VTRIQ 625

  Fly   403 QEAEATATQYRSELDSVNREQKSEQDTLDGETNRRASVEESFKKLTLQREEAVKRRDKLMDHIKS 467
            ::|.    |...:|...||:..|:.:                     ||::||          ::
Mosquito   626 KDAR----QIEQDLQERNRDGLSQVE---------------------QRKQAV----------ET 655

  Fly   468 SQAALEEQNRIKDELRRDVGTSKEKIAEKQRELE---DVRDQLGDAKSDKH--------EDARRK 521
            .:|.|:|:|   |||       ...||..|||::   :....:.||:.:||        |..|.:
Mosquito   656 EKAQLKERN---DEL-------ASMIASAQREVDLMYNTMAHVKDAREEKHHERCAKQSETTRIE 710

  Fly   522 KKQEVVE--------LFKKQVPGVYDRMINMCQP-----------------THKRYNVAVTKVLG 561
            |:.|..|        ::...:|.:..|:..:.|.                 .:|:::..|...||
Mosquito   711 KQLEQFESAPRSKLAVYGTNMPALVARIRQLHQQGQFSEMPRGPLGQYIEVRNKKWSGIVETALG 775

  Fly   562 KFMEAIIVDTEKTARHCIQILKEQMLEVETFLPLDYLQVKPLKE-RLRNISDPRNVRLVFDVLKF 625
            ..:.|..|.|::..|....:||.:..:::.........||.|.: |...:.:.....|:.:::|.
Mosquito   776 GCLSAFFVSTQEDWRTLDALLKREFPDLQNRTIFTGRFVKELYDVRSGCVQEQDGTHLLMNLIKV 840

  Fly   626 -EPQEIERAV-LFATGNALVCETPEDAMKVAYEIDR-----SRFDALALDGTFYQKSGLISGGSH 683
             :|..:.|.: ..|....||.|....|:::..||:.     |:.........|:.:....|.|
Mosquito   841 NDPVVMNRLIDSAAIDTILVTEHQSVAIQLTSEIENVPQNLSKVIVAEPCAEFFPQPKYRSYG-- 903

  Fly   684 DLARKAKRWDEKHMAQLK----MQKERLQEELKELVKKSRKQSELATVESQIKGLENRLKYSMVD 744
             |.:|..|:.:..|.:||    .::|:||.||.||.....|:.|
Mosquito   904 -LQQKPPRYLQVSMDELKRHTQQRREQLQRELNELNSAYAKEDE--------------------- 946

  Fly   745 LESSKKSISQYDNQLQQVQSQLDEFGPKILEIERRMQNREEHIQEIKENMNNVEDKVYASFCRRL 809
                                       ::.|:.|::..|::|::::::.:...|.::.    :..
Mosquito   947 ---------------------------RLQEMTRKLHQRQQHMKKLQQELLTNEQQLQ----QLA 980

  Fly   810 GVKNIRQYEERELVMQQERARKR---AEFEQQIDSINSQLDFEKQKDTKKNVERWERSVQDEEDA 871
            ||  :.:.|..|..:::|....|   |:.::.|:...::||     ..::.|::.|::.|.::||
Mosquito   981 GV--VFEGETEETTLREELEHSRTILAKLQKGIEEEQAKLD-----QVRRTVQQEEQTAQAKKDA 1038

  Fly   872 LEGLKLAEARYLKEIDE------DKEKMEKFKQDKQAKKQAVDDMEEDISKARKDVANLAKEIHN 930
            :..::...||....||:      |.:...|.||  ||.|::.:.|||   :.|..||
Mosquito  1039 MGAVEAEIARIQASIDKEQQARHDLQTNHKVKQ--QALKRSTESMEE---RKRTRVA-------- 1090

  Fly   931 VGSHLSAVESKIEAKKNERQNILLQAKTDCIVVPLLRGSLDDAVRQSDPDVPSTSAAMENIIEVD 995
                |||...:...:.:|                  :|...|...|    :||.
Mosquito  1091 ----LSAALEQARQEASE------------------KGERPDESEQ----IPSV----------- 1118

  Fly   996 YSSLPREYTKLKDDSAFKKTHEMLQKDLQSKLDVLE-RIQTPNMKALQ-KLDAVTEKVQSTNEEF 1058
                                     :.|:.|:...| ||:.  :.|.| ||:.|.|:::..|.|.
Mosquito  1119 -------------------------EQLKGKIHTTEKRIRL--VSATQDKLEDVVEELEGKNRER 1156

  Fly  1059 ENARKKAKRAKAAFERVKNERSSRFVACCQHISDAIDGIYKKLARNEAAQA------------YI 1111
            :...:.:...:...:.:::.|.|||    .|:        .||..:.|.:.            |:
Mosquito  1157 DELIRYSTALRDLTQMMRDIRKSRF----SHL--------HKLTTHMALRVKHKFTNIMQIRNYL 1209

  Fly  1112 GP--DNPEEPYL-------DGINYNCVAPGKRFQPMNNLSGGEKTIAALALLFSTHSFHPAPFFV 1167
            |.  .|.||..|       |....|.|:..|      :|||||::.|.:|.|.:..|....|||.
Mosquito  1210 GKLRVNQEECRLSLSVVPRDANVQNAVSTTK------SLSGGERSYATVAFLIALWSCVSTPFFF 1268

  Fly  1168 LDEIDAALDNTN 1179
            |||.|...|..|
Mosquito  1269 LDEYDVFTDQVN 1280

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC1	NP_651211.2	SMC_N	26..1222	CDD:481474	262/1247 (21%)
SelR	XP_061501760.1	None