Protein Alignment SMC1 and SMC4

DIOPT Version :9

• Sequence 1: NP_651211.2
• Gene: SMC1 / 42853
• FlyBaseID: FBgn0040283
• Length: 1238
• Species: Drosophila melanogaster
• Sequence 2: NP_001002800.1
• Gene: SMC4 / 10051
• HGNCID: 14013
• Length: 1288
• Species: Homo sapiens
• Alignment Length: 1312
• Identity: 318/1312 - (24%)
• Similarity: 584/1312 - (44%)
• Gaps: 253/1312 - (19%)

  Fly    27 LEYIEMENFKSYRGHIVVGPL-KQFNAVIGPNGSGKSNFMDAISFVMGEKTSSLRVKRLNDLIHG 90
            :.:|..:|||||.|..::||. |:|:.:||||||||||.:|::.||.|.:...:|.|:|:.|||.
Human    84 ITHIVNQNFKSYAGEKILGPFHKRFSCIIGPNGSGKSNVIDSMLFVFGYRAQKIRSKKLSVLIHN 148

  Fly    91 SSIGKPVSRSCYVTAKF--VLNEERHMDFQ-----------RAVIGGSSEYRINGESVSSSTYLN 142
            |...|.: :||.|...|  ::::|.. |::           .|....:|.|.|:|:..:.....|
Human   149 SDEHKDI-QSCTVEVHFQKIIDKEGD-DYEVIPNSNFYVSRTACRDNTSVYHISGKKKTFKDVGN 211

  Fly   143 KLEKIGINVKAKNFLVFQGAVENIAMKTPKERT-------ALFEEISGSGLLKDDYNRLKQEMIV 200
            .|...||::....||:.||.||.|||..||.:|       ...|:|.|.|.|.:....|.:.:.:
Human   212 LLRSHGIDLDHNRFLILQGEVEQIAMMKPKGQTEHDEGMLEYLEDIIGCGRLNEPIKVLCRRVEI 276

  Fly   201 AEEETQFTYQKKKGIAAERKEAKHEKMEADRYTRLQNEYNEKQVEYQLFRLFHVERDIRKFTSDL 265
            ..|.......:.|.:..|:...:.||..|..:..|:||...|:.....:.::.:::.|.:..:..
Human   277 LNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQK 341

  Fly   266 EVRQQEVKAVEQRKEAADEILREKKKDAGKITRDLAKIDQEIREFETQMNKRRPLYIKAKEKVTH 330
            |...::.|.:.::.......::.|.||.....:.|.||.:.|.|.:.:..:.....::.:||:.|
Human   342 EKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLKH 406

  Fly   331 CKKKLISLQKTLETAREADNAHQSDIRKLEKQLADVEALKKRFEDEIENESQRRGKSVNMEEGLV 395
            ...|...|:|.|:..:|.....:|...|....:.:........|.|.|.|          |:.|.
Human   407 ATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNALEKEKEKE----------EKKLK 461

  Fly   396 QEYDRLKQEAEATATQYRSELDSVNREQKSEQDTLDGETNRRASVEESFKKLTLQREE------- 453
            :..|.||||.:           .:.:|::|.:..|.|.:.   ||.|:..|:.:.:.|
Human   462 EVMDSLKQETQ-----------GLQKEKESREKELMGFSK---SVNEARSKMDVAQSELDIYLSR 512

  Fly   454 ---AVKRRDKLMDHIKSSQAALEEQNRIKDELRRDVGTSKEKIAEKQRELE-------------- 501
               ||.:..|..:.:.::...|:|:.....::...:..:::::.||::||:
Human   513 HNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVH 577

  Fly   502 DVRDQLGDAKSDKHEDARRKKKQEVVELFKK--QVPGVYDRMINMCQPTHKRYNVAVTKVLGKFM 564
            |:..::.:|||....:..|.|..:.:...||  ::||:|.|:.:: ....::|:||::... ..:
Human   578 DLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDL-GAIDEKYDVAISSCC-HAL 640

  Fly   565 EAIIVDTEKTARHCIQILKEQMLEVETFLPLDYLQVKPLKERLRNISDPRNVRLVFDVLKFEPQE 629
            :.|:||:...|:.|:..||.|.:.|.||:.||.:.|  ..:::..|..|.|...:||::|.:.::
Human   641 DYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAV--WAKKMTEIQTPENTPRLFDLVKVKDEK 703

  Fly   630 IERAVLFATGNALVCETPEDAMKVAYEIDRSRFDALALDGTFYQKSGLISGGSHDLARKAKRWDE 694
            |.:|..||..:.||.:..:.|.:|||:.|| |:..:.|.|...::||.::||..
Human   704 IRQAFYFALRDTLVADNLDQATRVAYQKDR-RWRVVTLQGQIIEQSGTMTGGGS----------- 756

  Fly   695 KHMAQLKMQKERLQEELKELVKKSRKQSELATVESQIKGLENRLKYSMVDLESSKKSISQYDNQL 759
                  |:.|.|:...|  :::.|  :.|:..:|||::             ..|||::     |:
Human   757 ------KVMKGRMGSSL--VIEIS--EEEVNKMESQLQ-------------NDSKKAM-----QI 793

  Fly   760 QQVQSQLDEFGPKILEIERRMQN--------------REEHIQ-EIKENMNNV------------ 797
            |:.:.||:|...|:...||.|:|              :||::. ::||...||
Human   794 QEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKL 858

  Fly   798 -EDKV------YASFCRRLG-----VKNIR----QYEERELVMQQERARKRAEFEQQIDSINSQL 846
             |:.|      |.:...:.|     ||.:.    :....:|..||::          :|.||.||
Human   859 LEENVSAFKTEYDAVAEKAGKVEAEVKRLHNTIVEINNHKLKAQQDK----------LDKINKQL 913

  Fly   847 D-------------------FEKQKD----TKKNVERWERSVQDEEDALEGLKLAEARYLKEIDE 888
            |                   .:|.:|    |:|.::..|:.|.|....|:.|:...|..:|..:.
Human   914 DECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNA 978

  Fly   889 DKEKMEKFKQDKQAKKQAVDDMEEDISKARKDVANLAKEIHNVGSHLSAVESKIEAKKNERQNIL 953
            .:|.:.:.:::.:...|.:..::|:....:||..::..::..:..|::...|||:....|...|.
Human   979 AEESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQIDGHIAEHNSKIKYWHKEISKIS 1043

  Fly   954 LQAKTDCIVVPLLRGSLDDAVRQSDPDVPSTSAAMENIIEVDYSSLPREYTKLKDD----SAFKK 1014
            |....|..:..:...|.:|.....:||..:...|:          |.....::|.:    :.:||
Human  1044 LHPIEDNPIEEISVLSPEDLEAIKNPDSITNQIAL----------LEARCHEMKPNLGAIAEYKK 1098

  Fly  1015 THEMLQKDLQSKLDVLERIQTPNMKALQKLDAVTEKVQSTNEEFENARKKAKRAKAAFERVKNER 1079
            ..|:          .|:|:        .:||.:|.:..|..:.:|:.||              :|
Human  1099 KEEL----------YLQRV--------AELDKITYERDSFRQAYEDLRK--------------QR 1131

  Fly  1080 SSRFVACCQHISDAIDGIYKKLARNEAAQAYIGPD------NPEEPYLDGINYNCVAPGKRFQPM 1138
            .:.|:|....|::.:...|:.|.        :|.|      :..:|:.:||.::...|.|.::.:
Human  1132 LNEFMAGFYIITNKLKENYQMLT--------LGGDAELELVDSLDPFSEGIMFSVRPPKKSWKKI 1188

  Fly  1139 NNLSGGEKTIAALALLFSTHSFHPAPFFVLDEIDAALDNTNIGKVASYIRDHTTNLQTIVISLKE 1203
            .||||||||:::|||:|:.|.:.|.|.:.:||||||||..|:..||.||.:.|.|.|.|:|||:.
Human  1189 FNLSGGEKTLSSLALVFALHHYKPTPLYFMDEIDAALDFKNVSIVAFYIYEQTKNAQFIIISLRN 1253

  Fly  1204 EFYGHADALVGI 1215
            ..:..:|.|:||
Human  1254 NMFEISDRLIGI 1265

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC1	NP_651211.2	Smc	26..1216	CDD:224117	318/1312 (24%)
		ABC_SMC1_euk	27..>171	CDD:213242	57/157 (36%)
		SMC_hinge	535..653	CDD:214944	34/117 (29%)
		DUF4700	<697..>810	CDD:292399	31/146 (21%)
		ABC_SMC1_euk	<1130..1232	CDD:213242	41/86 (48%)
SMC4	NP_001002800.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..55
		ABC_SMC4_euk	82..>241	CDD:213241	57/158 (36%)
		SMC_N	83..1274	CDD:280601	318/1312 (24%)
		DUF4349	<327..427	CDD:305044	19/99 (19%)
		SMC_hinge	613..727	CDD:214944	34/117 (29%)
		ABC_SMC4_euk	<1181..1275	CDD:213241	41/85 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D326079at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820