Protein Alignment SMC1 and smc6

DIOPT Version :9

• Sequence 1: NP_651211.2
• Gene: SMC1 / 42853
• FlyBaseID: FBgn0040283
• Length: 1238
• Species: Drosophila melanogaster
• Sequence 2: XP_031758814.1
• Gene: smc6 / 100495796
• -ID: -
• Length: 1122
• Species: Xenopus tropicalis
• Alignment Length: 1238
• Identity: 232/1238 - (18%)
• Similarity: 439/1238 - (35%)
• Gaps: 338/1238 - (27%)

  Fly    23 ETAFLEYIEMENFKSYRGHIVVGPLK---QFNAVIGPNGSGKSNFMDAISFVMGEKTS-SLRVKR 83
            |...:|.|.:.||..   |.::||.:   ..|.|:|.||||||..:.|:...:|.|.: :.|...
 Frog    77 EVGIIESISLRNFMC---HSMLGPFRFGPNVNFVVGNNGSGKSAILTALIVGLGGKAAFTNRGST 138

  Fly    84 LNDLIHGSSIGKPVSRSCYVTAKFVLNEERHMDF-------------QRAVIGGSSEYRINGESV 135
            :...|.|......:|    :|.:     .|..|.             ||....|...|::  :|.
 Frog   139 IKGFIKGGENFAEIS----ITLR-----NRGQDAYKPDVFGNSITVRQRITTEGGRTYKL--KSA 192

  Fly   136 SSSTYLNKLEKIGINVKAKNFLVFQGAVENIAMKTPKERTALFEEISGSGLLKDDYNRLKQEMIV 200
            :.:...||.|::.:.:...|.     .|:|......:|.:.||.:....   .|.|....:...:
 Frog   193 TGAVISNKKEELTMILDHFNI-----QVDNPVSVLTQEMSKLFLQSKNE---SDKYKFFMKATQL 249

  Fly   201 AEEETQFTYQKKKGIAAERKEAKHE--KMEADRYTRLQNEYNEKQVEYQLFR------------- 250
            .:.:..::|      ..|.|...|:  |:.::|...|:.:..:|:..:....
 Frog   250 EQMKEDYSY------IMETKSKTHDQVKIGSERLCDLRQDCIQKEESFNSIASLGEMKMNLDNLK 308

  Fly   251 -------LFHVERDIRKFTSDLEVRQQEVKAVEQRKE-------AADEILREKKKDAGKITRDLA 301
                   :...|:.|:.....:...:......|||.:       .|:|..|.|:::..|||::.|
 Frog   309 NSMAWALVIEAEKQIKPIRDQIVTEEGHTVKYEQRIDECQGKVNIAEEKFRAKQEELDKITQEAA 373

  Fly   302 KIDQEIREFETQMNKRRPLYIKAKEKVTHCKKKLISLQKTLETAREADNAHQSDIRKLEKQLADV 366
            ::              :|..|..|:.|          ||..::..:|:.::...|.:|::...|.
 Frog   374 EL--------------KPKVIALKDDV----------QKKRKSYNDAEASYNRQIMELKRSEKDA 414

  Fly   367 EALKKRFEDEIE----NESQRRGKSVNMEEGLVQEYDRLKQEAEATATQYRSELDSVNREQKSEQ 427
            |.|.||.| |::    |.|:|...:...|...:.|.....|..:.|.:|...:|.....:.|.:.
 Frog   415 EQLSKRIE-ELKKRDGNASEREKMARQQEIAQITERKEELQNHDITISQKIKQLQEAIEKHKEKW 478

  Fly   428 DTLDG-ETNRRASVEESFKKLTLQREEAVKRRDKLMDHIKSSQAALEEQNRIKDELRRDVGTSKE 491
            ..::. |.|.:..:|:..::|....|....|..:...:|.|..||::|...:....::..|....
 Frog   479 IRIENEEQNVKQRLEQHKRQLRELHESKTDRLKRFGKNIPSLLAAIDEAYNLGRFRKKPFGPLGA 543

  Fly   492 KIAEKQRELE-----DVRDQLGDAKSDKHED------------ARRKKKQEVVELFKKQVPGVYD 539
            .|..|.:||.     .::..|.....|.|:|            ::.::.|.:|..|..   .|||
 Frog   544 YIHLKDQELALAVECCLKGLLFAFCCDNHQDEGILQNIMSKQYSQGRRPQIIVSEFWN---NVYD 605

  Fly   540 RMINMCQPTHKRYNVAVTKVLGKFMEAIIVDTEKTARHCIQILKEQMLEVETFLPL-DYLQVKPL 603
              ::.....|..:...:|        |:.:|....|...|     .|..:||.|.: |..:.
 Frog   606 --VSQRASFHPNHPTVLT--------ALEIDHPVVANCLI-----DMRGIETILIIKDKTEA--- 652

  Fly   604 KERLRNISDPRNVRLVFDVLKFEPQEIERAVLFATGNALVCETPEDAMKVAYEIDRSRFDALALD 668
            :|.::....|||.|..|                 ||     |..:......|..|..|...|:.|
 Frog   653 REIMQKRVPPRNCREAF-----------------TG-----EGDQVYTNRYYSSDTRRATLLSRD 695

  Fly   669 GTFYQKSGLISGGSHDLARKAKRWDEKHMAQLKMQKERLQEELKELVKKSRKQSELATVESQIKG 733
                                           ::.:...|:|||::.      ..::||::..:..
 Frog   696 -------------------------------VEAEISHLEEELRDF------GGQVATLQQSVHS 723

  Fly   734 LENRLKYSMVDLESSKKSISQYDNQLQQVQSQLDEFGPKILEIERRMQNREEHIQEIKENMNNVE 798
            ::.       |::.::.::.:|.|..:|:|::|.....:|.|:|
 Frog   724 VDK-------DIKENEDNLRKYYNSKKQIQTELRTLSEQIAELE--------------------- 760

  Fly   799 DKVYASFCRRLGVKNIRQYEERELVMQQERARKRAEFEQQIDSINSQLDFEKQK---------DT 854
                          |:.:....::...::.|.:..|.   |:.:..:::..::.         ..
 Frog   761 --------------NVEEQPSTDIATLEKEAAENTEI---IELVKQEVELAQENMGNLKLLLTTA 808

  Fly   855 KKNVERWERSVQDEEDALEGLKLAEARYLKEIDEDKEKMEKFKQDKQAKKQAVDDMEEDISKARK 919
            :.|.|..:|.:....|..|.:|    ..|..||::.|..      |:.||..||.:::.:.:.:|
 Frog   809 ESNYEEIKRKIISVSDVAEPVK----EDLHRIDQEVENC------KRHKKHYVDKLKKHLDRIQK 863

  Fly   920 DVANLAKEIHNVGSHLSAVESKIEAKKNERQNILLQAKTDC---IVVPLLRGSLDDAVRQSDPDV 981
                 .||      .::..|.::|.|       :.|||..|   |.|.....|||..:.:....:
 Frog   864 -----RKE------EVAGKEQELEVK-------ISQAKYICPERIEVSRTARSLDTEINRLREKI 910

  Fly   982 PSTSAAMENIIEVDYSSLPREYTKLKDDSAFKKTHEMLQKDLQSKLDVLERIQTPNMKALQKLDA 1046
            .|     |.::..:...:..:|.:.|:          ..:|.:.|:..|.|..|       .||.
 Frog   911 NS-----EEVLHGNREEIIMQYYEAKE----------RYQDAERKIKHLNRFIT-------LLDT 953

  Fly  1047 VTEKVQSTNEEFENARKKAKRAKAAFERVKNERSSRFVACCQHISDAIDGIYKKLARNEAAQAYI 1111
            :.|:.....::|:  |....|.|..|..:.::|        :| |..|:..:|    ||.....:
 Frog   954 IMEQRHECFQKFQ--RSLTLRCKCFFNSLLSQR--------KH-SGKINFDHK----NETLSITV 1003

  Fly  1112 GPDNPEEPYLDGINYNCVAPGKRFQPMNNLSGGEKTIAALALLFSTHSFHPAPFFVLDEIDAALD 1176
            .|....:..|              ..|.:|||||::.:.:..:.|..|...:||..|||.|..:|
 Frog  1004 QPGEGNKAEL--------------SDMRSLSGGERSFSNVCFILSLWSIAESPFRCLDEFDVYMD 1054

  Fly  1177 NTN 1179
            ..|
 Frog  1055 MVN 1057

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC1	NP_651211.2	Smc	26..1216	CDD:224117	231/1235 (19%)
		ABC_SMC1_euk	27..>171	CDD:213242	37/160 (23%)
		SMC_hinge	535..653	CDD:214944	23/118 (19%)
		DUF4700	<697..>810	CDD:292399	15/112 (13%)
		ABC_SMC1_euk	<1130..1232	CDD:213242	16/50 (32%)
smc6	XP_031758814.1	Smc	81..1101	CDD:224117	231/1234 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910