Protein Alignment SMC1 and smc1a

DIOPT Version :10

• Sequence 1: NP_651211.2
• Gene: SMC1 / 42853
• FlyBaseID: FBgn0040283
• Length: 1238
• Species: Drosophila melanogaster
• Sequence 2: XP_002935560.1
• Gene: smc1a / 100493711
• XenbaseID: XB-GENE-972620
• Length: 1232
• Species: Xenopus tropicalis
• Alignment Length: 1237
• Identity: 606/1237 - (48%)
• Similarity: 865/1237 - (69%)
• Gaps: 39/1237 - (3%)

  Fly    26 FLEYIEMENFKSYRGHIVVGPLKQFNAVIGPNGSGKSNFMDAISFVMGEKTSSLRVKRLNDLIHG 90
            ||:.||:||||||:|..::||..:|.|:||||||||||.|||||||:|||||:||||.|.|||||
 Frog     3 FLKLIEIENFKSYKGRQIIGPFHRFTAIIGPNGSGKSNLMDAISFVLGEKTSNLRVKTLRDLIHG 67

  Fly    91 SSIGKPVSRSCYVTAKFVLNEERHMDFQRAVIGGSSEYRINGESVSSSTYLNKLEKIGINVKAKN 155
            :.:|||.:...:|:..:..:......|.|.::||||||:||.:.|..|.|.::|||:||.:||:|
 Frog    68 APVGKPAANRAFVSMVYSEDSGEEKVFSRVIVGGSSEYKINNKVVQLSEYSDELEKLGILIKARN 132

  Fly   156 FLVFQGAVENIAMKTPKERTALFEEISGSGLLKDDYNRLKQEMIVAEEETQFTYQKKKGIAAERK 220
            |||||||||:||||.||||||||||||.||.|..:|::.|:||:.|||:|||.|.:||.||||||
 Frog   133 FLVFQGAVESIAMKNPKERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERK 197

  Fly   221 EAKHEKMEADRYTRLQNEYNEKQVEYQLFRLFHVERDIRKFTSDLEVRQQEVKAVEQRKEAADEI 285
            |||.||.||:||.||::|....||:.|||:|:|.|.:|.|...||.|:.:.::..::..:..:|.
 Frog   198 EAKQEKEEAERYQRLKDEVARAQVQLQLFKLYHNESEIEKLNKDLSVKNKGIEKDKKHMDKVEEE 262

  Fly   286 LREKKKDAGKITRDLAKIDQEIREFETQMNKRRPLYIKAKEKVTHCKKKLISLQKTLETAREADN 350
            |::||||.||:.|:...|::||:|.:.::|::||.||||||..:|..|||.:.:|:|:.|::...
 Frog   263 LKDKKKDLGKMMREQQAIEKEIKEKDAELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKQYK 327

  Fly   351 AHQSDIRKLEKQLADVEALKKRFEDEIENESQRRGKSVNMEEGLVQEYDRLKQEAEATATQYRSE 415
            ..::|:.:|||::..||..::.||:.:|.|||.:|:.:.:||..|::|.|||:||...|.....|
 Frog   328 KRKADMDELEKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQVKKYHRLKEEASKRAATLAQE 392

  Fly   416 LDSVNREQKSEQDTLDGETNRRASVEESFKKLTLQREEAVKRRDKLMDHIKSSQAALEEQNRIKD 480
            |:..||:||::||.||.|..::...|...|:...:.||..||.:||.::|.:|:.:||||..:::
 Frog   393 LEKFNRDQKADQDRLDLEERKKVETEAKIKQKLREIEENQKRIEKLEEYIATSKQSLEEQKNLEE 457

  Fly   481 ELRRDVGTSKEKIAEKQRELEDVRDQLGDAKSDKHEDARRKKKQEVVELFKKQVPG-VYDRMINM 544
            .|..:|..:|.:|.|...||..|.:|||||:.|:.|.:|:::|.|::|..|:..|| ||.|:|::
 Frog   458 TLTEEVELAKRRIDEINSELNQVMEQLGDARIDRQESSRQQRKAEIMESIKRLYPGSVYGRLIDL 522

  Fly   545 CQPTHKRYNVAVTKVLGKFMEAIIVDTEKTARHCIQILKEQMLEVETFLPLDYLQVKPLKERLRN 609
            ||||.|:|.:||||||||.|:|||||:|||.|.|||.:|||..|.|||||||||:|||..|:||.
 Frog   523 CQPTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLRE 587

  Fly   610 ISDPRNVRLVFDVLKFEPQEIERAVLFATGNALVCETPEDAMKVAYEIDRSRFDALALDGTFYQK 674
            :   :..:||.||:::||..|::|:.:|.||||||:..|||.::|:. ...|...:|||||.:||
 Frog   588 L---KGAKLVIDVIRYEPPHIKKALQYACGNALVCDNVEDARRIAFG-GHQRHKTVALDGTLFQK 648

  Fly   675 SGLISGGSHDLARKAKRWDEKHMAQLKMQKERLQEELKELVKKSRKQSELATVESQIKGLENRLK 739
            ||:||||:.||..||:|||||.:.:||.:||||.|||||.:|..||::||..|:||..||:.|||
 Frog   649 SGVISGGASDLKAKARRWDEKAVDKLKEKKERLTEELKEQMKAKRKEAELRQVQSQAHGLQMRLK 713

  Fly   740 YSMVDLESSK-KSISQYDNQLQQVQSQLDEFGPKILEIERRMQNREEHIQEIKENMNNVEDKVYA 803
            ||..|||.:| :.::....:..:::|:|..|.|:|.:|:|.:|:||..::::||.||.|||:|:.
 Frog   714 YSQSDLEQTKTRHLAMNLQEKSKLESELANFSPRINDIKRIIQSREREMKDLKEKMNQVEDEVFE 778

  Fly   804 SFCRRLGVKNIRQYEERELVMQQERARKRAEFEQQIDSINSQLDFEKQ--KDTKKNVERWERSVQ 866
            .|||.:||:|||::||.::..|.|.|:||.|||.|...:..|||:||.  |:.:..|:.||:||:
 Frog   779 EFCREIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDYEKNQLKEDQGKVQTWEQSVK 843

  Fly   867 DEEDALEGLKLAEARYLKEIDEDKEKMEKFKQDKQAKKQAVDD---MEEDISK----ARKDVANL 924
            .:::.:|.||..|.|::|.|||...:::..|....|||..|:|   :.|||.|    |.|:|.:|
 Frog   844 KDDNEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHLMEDIRKKLGSANKEVTHL 908

  Fly   925 AKEIHNVGSHLSAVESKIEAKKNERQNILLQAKTDCIVVPLLRGSLDDAVRQ----------SDP 979
            .||:       :|:|:|:|.|:::|.|:|...|...|.:||.:|::||..::          |..
 Frog   909 QKEV-------TAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQEEGGSQGEESVSSS 966

  Fly   980 DVPSTSAAMENIIEVDYSSLPREYTKLKD---DSAFKKTHEMLQKDLQSKLDVLERIQTPNMKAL 1041
            ...||..|.|.::|:|||.|..:   |||   |...|:....|.:.|..:..:|:||..|||||:
 Frog   967 QRSSTVYAKEALLEIDYSDLSED---LKDAVADDDIKQEMSALHQKLNEQQSILQRIAAPNMKAM 1028

  Fly  1042 QKLDAVTEKVQSTNEEFENARKKAKRAKAAFERVKNERSSRFVACCQHISDAIDGIYKKLARNEA 1106
            :||::|.:|.|.|::|||.|||:||:||.|||:.|.||..||.||.:.::..||.|||.|:||.:
 Frog  1029 EKLESVRDKFQETSDEFEAARKRAKKAKQAFEQTKKERFDRFNACFESVATNIDEIYKALSRNSS 1093

  Fly  1107 AQAYIGPDNPEEPYLDGINYNCVAPGKRFQPMNNLSGGEKTIAALALLFSTHSFHPAPFFVLDEI 1171
            |||::||:|||||||||||||||||||||:||:||||||||:|||||||:.||:.|:||||||||
 Frog  1094 AQAFLGPENPEEPYLDGINYNCVAPGKRFRPMDNLSGGEKTVAALALLFAIHSYKPSPFFVLDEI 1158

  Fly  1172 DAALDNTNIGKVASYIRDHT-TNLQTIVISLKEEFYGHADALVGITPGEGDCLVSNVYIMDLTTF 1235
            |||||||||||||:||::.: :|.|.||||||||||..|::|:|:.|.:|||::|.|...|||.:
 Frog  1159 DAALDNTNIGKVANYIKEQSMSNFQAIVISLKEEFYTKAESLIGVYPEQGDCVISKVLTFDLTKY 1223

  Fly  1236 ED 1237
            .|
 Frog  1224 PD 1225

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC1	NP_651211.2	SMC_N	26..1222	CDD:481474	598/1220 (49%)
smc1a	XP_002935560.1	SMC_N	3..1210	CDD:426784	598/1220 (49%)