Protein Alignment SMC1 and smc2

DIOPT Version :9

• Sequence 1: NP_651211.2
• Gene: SMC1 / 42853
• FlyBaseID: FBgn0040283
• Length: 1238
• Species: Drosophila melanogaster
• Sequence 2: XP_002936738.3
• Gene: smc2 / 100486893
• XenbaseID: XB-GENE-5826169
• Length: 1202
• Species: Xenopus tropicalis
• Alignment Length: 1320
• Identity: 326/1320 - (24%)
• Similarity: 579/1320 - (43%)
• Gaps: 306/1320 - (23%)

  Fly    30 IEMENFKSYRGHIVVG---PLKQFNAVIGPNGSGKSNFMDAISFVMG-EKTSSLRVKRLNDLIH- 89
            |.::.||||.....:.   ||  |||:.|.|||||||.:|:|.|::| ...:.:|...|.||::
 Frog     6 IIIDGFKSYAQRTEINGFDPL--FNAITGLNGSGKSNILDSICFLLGISNLTQVRASNLQDLVYK 68

  Fly    90 --GSSIGK---PVSRSCYVTAKFVLNEERHMDF---QRAVIGGSSEYRINGESVSSSTYLNKLEK 146
              .:.|.|   .::...|...:..|..|.|.:.   ::.||||.::|.|||.:.:::...:....
 Frog    69 NGQAGITKATVSITFDNYDKKQSPLGFEAHDEITVTRQVVIGGRNKYLINGVNANNTRVQDLFCS 133

  Fly   147 IGINVKAKNFLVFQGAVENIAMKTPKERTALFEEISGSGLLKDDYNRLKQEMIVAEEETQFTYQK 211
            :|:||...:||:.||.:..:....|.|..|:.||.:|:.:                      |:.
 Frog   134 VGLNVNNPHFLIMQGRITKVLNMKPPEILAMIEEAAGTRM----------------------YEC 176

  Fly   212 KKGIAA----ERKEAKHEKMEA---DRYTRLQNEYNEKQ---VEYQLFRLFHVERDIRKFTSDLE 266
            || |||    |:||||.::::.   :..|...::..|::   :|||     .:.|:| :..|.|.
 Frog   177 KK-IAAQKTIEKKEAKLKEIQTILEEEITPTIHKLKEERSSYLEYQ-----KIMREI-EHLSRLY 234

  Fly   267 VRQQ-------EVKAVEQRKEAADEILR---------EKKKDAGKITRDLAKI-DQEI------- 307
            :..|       :|::.|:.||..|.||:         .|.|:.||...:|.|: |||:
 Frog   235 IAYQFVCAEETKVRSAEELKEMQDSILKLQDTMAENERKVKELGKEIAELEKLRDQEVGGALRSL 299

  Fly   308 -------REFETQMNKRRPL---YIKAKEKVTHCKKKLISLQKTLETAREADNAHQSDIRKLEKQ 362
                   :..:|::.....|   .:||:||    |:|  .|.|::|...:|..|.:.:::|:...
 Frog   300 EEALAEAQRSDTKVQSALDLKKQNMKAEEK----KRK--ELVKSMEEDAKALTAKEKEVKKITDS 358

  Fly   363 LADVEALKKRFEDEIENESQR-----RGKSVNMEEG----LVQEYDRLKQE---AEATATQYRSE 415
            |:.::...::..:.:....|.     .|.|.| |:|    |..:....|.|   ||..|.|.:.:
 Frog   359 LSSLQETSQKDAEALTGAQQHFNAVSAGLSSN-EDGEEATLAGQMMACKNEISKAETEAKQAQMK 422

  Fly   416 LDSVNREQKSEQDTLDGETNRRASVEESFKKLTLQREEAVKRRDKLMDHIKSSQAALE-EQNRIK 479
            |....:|.|::|          |.|    ||:    :...|:.::..:.:|.|:..|| |..::.
 Frog   423 LKHAQQELKTKQ----------AEV----KKM----DSGYKKDNEAFEAVKKSKEKLEVEMKKLN 469

  Fly   480 DELRRDVGTSKEKIAEKQRELEDVRDQLGDA----------------KSDKHEDARRKKKQEVVE 528
            .|..|:     |::.||:|.|....::|.:|                ..:|:.|:.|
 Frog   470 YEDGRE-----EQLLEKRRGLSRDVNRLREAYESLMARFPNLQFEYKDPEKNWDSSR-------- 521

  Fly   529 LFKKQVPGVYDRMINMCQPTHKRYNVAVTKVLGKFMEAIIVDTEKTARHCIQILKEQMLEVETFL 593
                 |.|:...:|::...:..   .|:..|.|..:..::||||.|.:..::  |.::....|.:
 Frog   522 -----VKGLVASLISVKDVSTA---TALEVVAGGRLYNVVVDTEVTGKKLLE--KGELKRRFTII 576

  Fly   594 PLDYLQVKPL-KERL---RNISDPRNVRLVFDVLKFEPQEIERAVLFATGNALVCETPEDAMKVA 654
            ||:.:..:.| |:.:   :|:....||.|...::.:| .|:::|:.:..|..|||:|.::|.||.
 Frog   577 PLNKISARCLGKDTVNVAKNLVGADNVHLALSLVGYE-SELQKAMEYVFGTTLVCDTMDNAKKVT 640

  Fly   655 YEIDRS-RFDALALDGTFYQKSGLISGG--SHDLARKAKRWDEKHMAQLKMQKERLQEELKELVK 716
            :  ||. ....:.|.|..:...|.:|||  |.:.:..||..:.||          :||||:
 Frog   641 F--DRKIMTKTVTLGGDTFDPQGTLSGGARSQNASVLAKLQELKH----------VQEELR---- 689

  Fly   717 KSRKQSELATVESQIKGLEN------------RLKYSMVDLESSKKSISQYDNQLQQVQSQLDEF 769
              .|:::|..||.::..|:|            .:|....||..:|...|.|..|    |.:||
 Frog   690 --AKETQLQEVEKELMSLKNTVERYRQLKQQWEMKSEEADLLQTKLQQSSYHKQ----QEELD-- 746

  Fly   770 GPKILEIERRMQNREEHIQEIKENMNNVEDKVYASFCRRLGVKNIRQYEERELVMQQERARKRAE 834
                 .:::.::..||.:::.||.....|:|             .:..|.:....:.||.|:..|
 Frog   747 -----TLKQTIEGSEETLKKTKEVQMKAEEK-------------FKVLEHKMKNAEAERERELKE 793

  Fly   835 FEQQIDSINSQLDFEKQKDTKKNVERWERSVQDEEDA----LEGLKLAEARYLKEIDEDKEKMEK 895
            .:|::|....:.|...:|..:|         |.|.||    ||.||..:..|.::|:...|.|:.
 Frog   794 AQQKLDGAKKKADASNKKMKEK---------QQEVDAFVLELEELKREQTTYKQQIEVVDEAMKA 849

  Fly   896 FKQDKQAKKQAVDDMEEDISKARKDVANLAKEIHNVGSHLSAVESK-IEAKKNERQNILLQAKTD 959
            :::........|...:|.:.||:::   |||:...:..|...:::| .||.|....|..||.|..
 Frog   850 YQEQADNMASEVAKNKESVKKAQEE---LAKQKEIIMGHDKEIKTKSAEAGKLRENNNDLQLKIK 911

  Fly   960 CIVVPLLRGSLDDAVRQSDPDVPSTSAAMENIIEVDYSSLPRE-YTKLKDDSAF-------KKTH 1016
                     .|:..:.:...|....:|.:..::. ||..:..| :...:.::|:       |:..
 Frog   912 ---------ELEHNISKHKKDSADAAAKVAKMLN-DYEWIASEKHLFGQANTAYDFKTNNPKEAG 966

  Fly  1017 EMLQKDLQSKLDVLERIQTPNMKALQKLDAVTE-----------------KVQSTNEEFENARKK 1064
            :.||| ||.|.:.|.|  ..||:|:..|....|                 |:.:|.||.:  :||
 Frog   967 QRLQK-LQEKKEKLGR--NVNMRAMNMLTQAEERYNDLMKKKRIVENDKSKILTTIEELD--QKK 1026

  Fly  1065 AKRAKAAFERVKNERSSRFVACCQHISDAIDGIYKKLARNEAAQAYIGPDNPE-EPYLDGINYNC 1128
            .:....|:::|..:..|.|       |..:.|          |.|.:.|  || :..|||:.:.
 Frog  1027 NEALNIAWQKVNKDFGSIF-------STLLPG----------ANAMLAP--PEGQSVLDGLEFK- 1071

  Fly  1129 VAPGKRF-QPMNNLSGGEKTIAALALLFSTHSFHPAPFFVLDEIDAALDNTNIGKVASYIRDHTT 1192
            ||.|..: :.:..||||::::.||:|:.:...|.|||.::|||:|||||.::...:...:|.|..
 Frog  1072 VALGNTWKENLTELSGGQRSLVALSLILAMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFR 1136

  Fly  1193 NLQTIVISLKEEFYGHADAL 1212
            :.|.||:|||:..:.:|:.|
 Frog  1137 HSQFIVVSLKDGMFNNANVL 1156

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC1	NP_651211.2	Smc	26..1216	CDD:224117	326/1320 (25%)
		ABC_SMC1_euk	27..>171	CDD:213242	47/153 (31%)
		SMC_hinge	535..653	CDD:214944	29/121 (24%)
		DUF4700	<697..>810	CDD:292399	26/124 (21%)
		ABC_SMC1_euk	<1130..1232	CDD:213242	31/84 (37%)
smc2	XP_002936738.3	Smc	1..1168	CDD:224117	326/1320 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000