Protein Alignment SMC1 and smc1b

DIOPT Version :10

• Sequence 1: NP_651211.2
• Gene: SMC1 / 42853
• FlyBaseID: FBgn0040283
• Length: 1238
• Species: Drosophila melanogaster
• Sequence 2: XP_031753497.1
• Gene: smc1b / 100145425
• XenbaseID: XB-GENE-997265
• Length: 1242
• Species: Xenopus tropicalis
• Alignment Length: 1229
• Identity: 513/1229 - (41%)
• Similarity: 767/1229 - (62%)
• Gaps: 48/1229 - (3%)

  Fly    26 FLEYIEMENFKSYRGHIVVGPLKQFNAVIGPNGSGKSNFMDAISFVMGEKTSSLRVKRLNDLIHG 90
            |::.:.:|||||:.|..|:||..:||.|||||||||||.|||.|||||||.::|||:.:..||||
 Frog     3 FMKQLIIENFKSWGGRQVIGPFLRFNCVIGPNGSGKSNLMDAFSFVMGEKPANLRVRNIRQLIHG 67

  Fly    91 SSIGKPVSRSCYVTAKFVL------NEERHMDFQRAVIGGSSEYRINGESVSSSTYLNKLEKIGI 149
            :::|||:|    .||:.||      .|||  .|.|.::|.||||||:|:.|..|||:.:||:|||
 Frog    68 ANVGKPMS----TTARVVLVYSEENGEER--QFSRIIVGDSSEYRIDGKPVGRSTYVMELERIGI 126

  Fly   150 NVKAKNFLVFQGAVENIAMKTPKERTALFEEISGSGLLKDDYNRLKQEMIVAEEETQFTYQKKKG 214
            .|||:|.|||||.||::|||.|:|||.|||:||.|..|.|:|.:.|:.|:.|||:.||.|.|||.
 Frog   127 IVKARNCLVFQGEVESLAMKKPRERTHLFEQISNSWELADEYEKKKKLMLQAEEDAQFCYNKKKN 191

  Fly   215 IAAERKEAKHEKMEADRYTRLQNEYNEKQVEYQLFRLFHVERDIRKFTSDLEVRQQEVKAVEQRK 279
            .|.:||.|..||.|||||..||....|.:||.||::|||.||.:......||.:|.:....:::.
 Frog   192 AAVQRKHATLEKAEADRYKALQQNLKETKVELQLYQLFHNERKLESVVRSLEEKQSDANRQKEQL 256

  Fly   280 EAADEILREKKKDAGKITRDLAKIDQEIREFETQMNKRRPLYIKAKEKVTHCKKKLISLQKTLET 344
            ..|:..|:.:|.:.|:.||||.:|::||:..|..::..||.:|||||...|..||:.:.:|.:..
 Frog   257 VRAESALKSEKAELGRCTRDLQQIEKEIKVQEVSLSHLRPQFIKAKENTAHHLKKVETAKKNVAN 321

  Fly   345 AREADNAHQSDIRKLEKQLADVEALKKRFEDEIENESQRRGKSVNMEEGLVQEYDRLKQEAEATA 409
            ..:..:..:.|..:||.::.|:|...:.||.::|.:.|||...:.:||...::|..||:||...:
 Frog   322 NEKQCHKLEQDKSELETEIEDIETAWRLFERKVEEDRQRRLGDIELEESQREQYRELKEEANKES 386

  Fly   410 TQYRSELDSVNREQKSEQDTLDGETNRRASVEESFKKLTLQREEAVKRRDKLMDHIKSSQAALEE 474
            ...|.:||.:..||||.|:.|:....|:..|:.:.|.:..|.||..||.:||.::|.:...::||
 Frog   387 AVLRQQLDRLQWEQKSAQEKLEFVLTRQKEVQVNKKHVEEQIEEHNKRIEKLEEYINTCLKSIEE 451

  Fly   475 QNRIKDELRRDVGTSKEKIAEKQRELEDVRDQLGDAKSDKHEDARRKKKQEVVELFKKQVP-GVY 538
            |...:::|..::..||:::.|...:|..:..:|.:|:.|.||.:|:|:|.||:|..|:..| .|:
 Frog   452 QRPQEEQLAGEIKASKQRMVEINEQLNSIVGELQNARIDFHEGSRQKRKAEVLESMKRMYPDAVF 516

  Fly   539 DRMINMCQPTHKRYNVAVTKVLGKFMEAIIVDTEKTARHCIQILKEQMLEVETFLPLDYLQVKPL 603
            .|:..:|.|.||:|.:|||||.||:|.||||.|.:.||.|::.|||:..|.||||.||||.:|.:
 Frog   517 GRLFELCHPIHKKYQLAVTKVFGKYMNAIIVSTVQVARDCVKFLKEERAEPETFLALDYLDIKQI 581

  Fly   604 KERLRNISDPRNVRLVFDVLKFEPQEIERAVLFATGNALVCETPEDAMKVAYEIDRSRFDALALD 668
            .|:||.|   :..:::.||::.....:::.:.|..||.|||:|.::|.::|:: ...|..|:|||
 Frog   582 NEKLREI---KGAKMMVDVIQTVSAPLKKVIQFVCGNGLVCDTVKEAKRIAFD-GPERLKAVALD 642

  Fly   669 GTFYQKSGLISGGSHDLARKAKRWDEKHMAQLKMQKERLQEELKELVKKSRKQSELATVESQIKG 733
            ||.:.|||:|||||.||..||||||||.:.:||.:::.|..|||||:|..|::|:|..:::|::|
 Frog   643 GTLFLKSGVISGGSSDLRYKAKRWDEKEINELKEKRDALMAELKELIKLQRRESDLKQLQAQLQG 707

  Fly   734 LENRLKYSMVDLE-SSKKSISQYDNQLQQVQSQLDEFGPKILEIERRMQNREEHIQEIKENMNNV 797
            .:.|:|||..::| ..||.::....:..::.|:|..|..::..:...:......|.:|:|.||.|
 Frog   708 TQTRMKYSQSEVEVVKKKHLANCSMEKSRLDSELANFASQLTMLREELDVHGTKIGDIQEQMNQV 772

  Fly   798 EDKVYASFCRRLGVKNIRQYEERELVMQQERARKRAEFEQQIDSINSQLDFEKQKDTK--KNVER 860
            ||:|:..||..:||.|||.|||..:..|||..:||.||:.|...:..||::.:.:..|  .|:::
 Frog   773 EDRVFKDFCEAIGVPNIRAYEEEYVQQQQEMDKKRLEFDNQKTRLGIQLEYIRGQLEKGRSNIDK 837

  Fly   861 WERSVQDEEDALEGLKLAEARYLKEIDEDKEKMEKFKQDKQAKKQAVDDMEEDISKARKDVANLA 925
            .::::|.||.....||..|.:.:|.:|:...:.::||.:...||..|.|.::.:.:|||.:.|:.
 Frog   838 SKQTLQKEEGDKVRLKKEEEQCMKAVDKAMAQQQQFKNNFTFKKSEVADAQKKVEEARKALLNVN 902

  Fly   926 KEIHNVGSHLSAVESKIEAKKNERQNILLQAKTDCIVVPLLRGSLDDAVR-QSDPDVPSTSAA-- 987
            :|:.......:.:|:.:|.||.||.|:||..|...|.:.||.|||||... :.|.:..||.|.
 Frog   903 REMSKKQKEAAVIENSVEQKKIERHNLLLDCKVQDIQIILLTGSLDDITEIELDTETESTQATAD 967

  Fly   988 ---MENIIEVDYSSLPREYTKLKDDSAFKKTHEMLQKDLQSKLDVLER---------IQT-PNMK 1039
               .|..|::||..|.::...|..|           |::.::|..|.:         ::| ||:|
 Frog   968 IYEREGNIQIDYRGLRKDLKSLVTD-----------KEISAELMTLRQETITLENTLLKTAPNLK 1021

  Fly  1040 ALQKLDAVTEKVQSTNEEFENARKKAKRAKAAFERVKNERSSRFVACCQHISDAIDGIYKKLARN 1104
            ||:||.:|.:|.|...:.||.:|||||..:..||:||..|...|..|.:|:..|||.|||||.||
 Frog  1022 ALEKLHSVRDKFQEAADAFEASRKKAKLCRNEFEQVKKRRYELFSRCFEHVCVAIDQIYKKLCRN 1086

  Fly  1105 EAAQAYIGPDNPEEPYLDGINYNCVAPGKRFQPMNNLSGGEKTIAALALLFSTHSFHPAPFFVLD 1169
            .:|||::.|:|||||||:||.|||.||||||..|:|||||||.:|||||:|:.|||.|||||:||
 Frog  1087 PSAQAFLSPENPEEPYLEGIAYNCSAPGKRFMSMDNLSGGEKAVAALALVFAIHSFRPAPFFILD 1151

  Fly  1170 EIDAALDNTNIGKVASYIRDHT-TNLQTIVISLKEEFYGHADALVGITPGEGDCLVSNV 1227
            |:||||||:|||||.||||:.: ...|.:|||||||||..||||:|:...:.:.:.|.|
 Frog  1152 EVDAALDNSNIGKVTSYIREESREQFQVVVISLKEEFYSRADALIGVCAEQEEAISSKV 1210

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC1	NP_651211.2	SMC_N	26..1222	CDD:481474	511/1222 (42%)
smc1b	XP_031753497.1	SMC_N	3..1198	CDD:481474	510/1215 (42%)