DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp68 and ECM10

DIOPT Version :9

Sequence 1:	NP_524474.1	Gene:	Hsp68 / 42852	FlyBaseID:	FBgn0001230	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_010884.1	Gene:	ECM10 / 856682	SGDID:	S000000756	Length:	644	Species:	Saccharomyces cerevisiae

Alignment Length:	628	Identity:	305/628 - (48%)
Similarity:	417/628 - (66%)	Gaps:	31/628 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IGIDLGTTYSCVGVFQYGKV-EIIANDQGNRTTPSYVAFT-DSERLIGDAAKNQVAMNPKNSVFD 66
            ||||||||.|.|.:.: ||| .||.|.:|:|||||.|||| |.|||:|:.||.|..:|.:|::|.
Yeast    30 IGIDLGTTNSAVAIME-GKVPRIIENAEGSRTTPSVVAFTKDGERLVGEPAKRQSVINSENTLFA 93

  Fly    67 AKRLIGRRFDDSKIQEDIKHWPFKVI-NDNGKPKISVEFKGANKCFSPEEISSMVLTKMKETAEA 130
            .||||||||:|:::|.||...|||:: :.||...:    :..|:.:||.:|...:|.||||||||
Yeast    94 TKRLIGRRFEDAEVQRDINQVPFKIVKHSNGDAWV----EARNRTYSPAQIGGFILNKMKETAEA 154

  Fly   131 YLGTTVKDAVITVPAYFNDSQRQATKDAGAIAGINVLRIINEPTAAALAYGLDKNLKGERNVL-I 194
            ||..:||:||:||||||||:|||||||||.|.|:||||::||||||||||||||:   |..|: :
Yeast   155 YLAKSVKNAVVTVPAYFNDAQRQATKDAGQIIGLNVLRVVNEPTAAALAYGLDKS---EPKVIAV 216

  Fly   195 FDLGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVNHFAEEFKRKYKKDLRSNPRALR 259
            |||||||||:|||.||.| :|||:||.|||||||||||..|:......||::...||.::..|::
Yeast   217 FDLGGGTFDISILDIDNG-IFEVKSTNGDTHLGGEDFDIYLLQEIISHFKKETGIDLSNDRMAVQ 280

  Fly   260 RLRTAAERAKRTLSS--STEASLEI---DALYEGHDFYSKVSRARFEELCGDLFRNTLEPVEKAL 319
            |:|.|||:||..|||  |||.:|..   ||....| .....||.:.|.:...|...|::||:|||
Yeast   281 RIREAAEKAKIELSSTLSTEINLPFITADAAGPKH-IRMPFSRVQLENITAPLIDRTVDPVKKAL 344

  Fly   320 KDAKMDKSQIHDIVLVGGSTRIPKVQNLLQNFFGGKTLNLSINPDEAVAYGAAIQAAILSGDKSS 384
            |||::..|.|.|::||||.:|:|||.:.::..| ||..:.::|||||||.|||||||:|||
Yeast   345 KDARITASDISDVLLVGGMSRMPKVADTVKKLF-GKDASKAVNPDEAVALGAAIQAAVLSG---- 404

  Fly   385 EIKDVLLVDVAPLSLGIETAGGVMTKLIERNSRIPCKQSKTFTTYADNQPAVTIQVFEGERALTK 449
            |:.||||:||.||||||||.|||.||||.|||.||.|:|:.|:|.|..|.:|.::||:|||.|.|
Yeast   405 EVTDVLLLDVTPLSLGIETLGGVFTKLIPRNSTIPNKKSQIFSTAASGQTSVEVKVFQGERELVK 469

  Fly   450 DNNVLGTFDLTGVPPAPRGVPKIDVTFDLDANGILNVTAKEQGTGNAKNITIKNDKGRLSQADID 514
            ||.::|.|.|.|:||||:|.|:|:||||:|||||:||:||:..:....:||:....| ||..:||
Yeast   470 DNKLIGNFTLAGIPPAPKGTPQIEVTFDIDANGIINVSAKDLASHKDSSITVAGASG-LSDTEID 533

  Fly   515 RMLSEAEKYAEEDERHRQRIAARNQLETYLFGVKEAAENGGDRISAADKSSIVERCSEAMKWLDS 579
            ||::|||:|..:|...|..|...|:.:......:.:.:....::...|...:.::.| :::.|.|
Yeast   534 RMVNEAERYKNQDRARRNAIETANKADQLANDTENSIKEFEGKLDKTDSQRLKDQIS-SLRELVS 597

  Fly   580 NTTAEKE----EYEYKLKELEQFCSPIMTKMHKGGGDGQQAPN 618
            .:.|..|    :...|:..|......:..:::| ..|..:..|
Yeast   598 RSQAGDEVNDDDVGTKIDNLRTSSMKLFEQLYK-NSDNPETKN 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp68	NP_524474.1	PTZ00009	2..635	CDD:240227	305/628 (49%)
Hsp68	NP_524474.1	HSPA1-2_6-8-like_NBD	3..379	CDD:212675	207/383 (54%)
ECM10	NP_010884.1	dnaK	29..644	CDD:234715	305/628 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810