DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp68 and LHS1

DIOPT Version :9

Sequence 1:	NP_524474.1	Gene:	Hsp68 / 42852	FlyBaseID:	FBgn0001230	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_012850.1	Gene:	LHS1 / 853789	SGDID:	S000001556	Length:	881	Species:	Saccharomyces cerevisiae

Alignment Length:	706	Identity:	164/706 - (23%)
Similarity:	307/706 - (43%)	Gaps:	116/706 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IGIDLG-TTYSCVGVFQYGKVEIIANDQGNRTTPSYVAF-----------TDSERLIGDAAKNQV 56
            :|:|.| .....:.|.....:|::...:..|...|.::.           ...||:.|.|..:..
Yeast    23 LGVDYGQQNIKAIVVSPQAPLELVLTPEAKRKEISGLSIKRLPGYGKDDPNGIERIYGSAVGSLA 87

  Fly    57 AMNPKNSVFDAKRLIGRRFDD-------SKIQEDIKHWPFKVINDNGKPKISVEFKGANKCFSPE 114
            ...|:|::...|.|:|:..:|       ||     :|...::::.|   :.::.|...|..:..|
Yeast    88 TRFPQNTLLHLKPLLGKSLEDETTVTLYSK-----QHPGLEMVSTN---RSTIAFLVDNVEYPLE 144

  Fly   115 EISSMVLTKMKETAEAYL---GTTVKDAV----ITVPAYFNDSQRQATKDAGAI-AGINVLRIIN 171
            |:.:|.:.::...|.:.|   ....:|.|    .|:|.:|:..||:|..||.:| .||....:::
Yeast   145 ELVAMNVQEIANRANSLLKDRDARTEDFVNKMSFTIPDFFDQHQRKALLDASSITTGIEETYLVS 209

  Fly   172 EPTAAALAYGLDKNL--KGE-RNVLIFDLGGGTFDVSILTI------DEGSLFEVRSTAGDTHLG 227
            |..:.|:.:.|.:..  .|| ::.:::|:|.|:...|:.:|      .:....|......:.|||
Yeast   210 EGMSVAVNFVLKQRQFPPGEQQHYIVYDMGSGSIKASMFSILQPEDTTQPVTIEFEGYGYNPHLG 274

  Fly   228 GE----DFDNRLVNHFAEEFKRKYKKDLRSNPRALRRLRTAAERAKRTLSSSTEASLEIDALYEG 288
            |.    |..:.:.|.|.|........:|.:||:||.::..|||:||..||:::|||:.|::|...
Yeast   275 GAKFTMDIGSLIENKFLETHPAIRTDELHANPKALAKINQAAEKAKLILSANSEASINIESLIND 339

  Fly   289 HDFYSKVSRARFEELCGDLFRNTLEPVEKALKDA----KMDKSQIHDIVLVGGSTRIPKVQNLLQ 349
            .||.:.::|..|||...|...:.::|:..|:...    ..:..:|:.::|.|||:|||.||:.|.
Yeast   340 IDFRTSITRQEFEEFIADSLLDIVKPINDAVTKQFGGYGTNLPEINGVILAGGSSRIPIVQDQLI 404

  Fly   350 NFFGGKTLNLSINPDEAVAYGAAIQAAILSGDKSSEIKDVLLVDVAPLSLGIETAG-GVMTKLIE 413
            .....:.:..::|.||:...|..::...||  .|.:.|.:.:||.:..:...:.:. ..:..:..
Yeast   405 KLVSEEKVLRNVNADESAVNGVVMRGIKLS--NSFKTKPLNVVDRSVNTYSFKLSNESELYDVFT 467

  Fly   414 RNSRIPCKQSKTFTTYADNQP-AVTIQVFEG----ERALTKDNNVLGTFD----LTGVPPAPRGV 469
            |.|..|.|.| ..|...|:.| ..||.:||.    |........:..::.    .:||
Yeast   468 RGSAYPNKTS-ILTNTTDSIPNNFTIDLFENGKLFETITVNSGAIKNSYSSDKCSSGV------- 524

  Fly   470 PKIDVTFDLDANGILN------VTAKEQGTGNAKNITIKNDKGRLSQADID-RMLSEAE------ 521
             ..::||||.::.:.:      :...|...||:|.|..|..:...:..|:: :.||.:|
Yeast   525 -AYNITFDLSSDRLFSIQEVNCICQSENDIGNSKQIKNKGSRLAFTSEDVEIKRLSPSERSRLHE 588

  Fly   522 --KYAEEDERHRQRIAAR-NQLETYLFGVK------EAAENGGDRISAADKSSIVERCSEAMK-- 575
              |..::.::.|.:.... |.||:.|:..:      |..:||        ..|.||..||.:|
Yeast   589 HIKLLDKQDKERFQFQENLNVLESNLYDARNLLMDDEVMQNG--------PKSQVEELSEMVKVY 645

  Fly   576 --WL-DSNTTAEKEEYEYKLKELEQFCSPIMTKMHKGGGDGQQAPNFGQQAGGYKG 628
              || |::...:.|:...:::|:     .|:.|..:...|..:.|...||   :||
Yeast   646 LDWLEDASFDTDPEDIVSRIREI-----GILKKKIELYMDSAKEPLNSQQ---FKG 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp68	NP_524474.1	PTZ00009	2..635	CDD:240227	164/706 (23%)
Hsp68	NP_524474.1	HSPA1-2_6-8-like_NBD	3..379	CDD:212675	101/418 (24%)
LHS1	NP_012850.1	HYOU1-like_NBD	23..430	CDD:212672	101/414 (24%)
LHS1	NP_012850.1	Smc	<581..737	CDD:224117	29/129 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810