DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp68 and SSC1

DIOPT Version :9

Sequence 1:	NP_524474.1	Gene:	Hsp68 / 42852	FlyBaseID:	FBgn0001230	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_012579.1	Gene:	SSC1 / 853503	SGDID:	S000003806	Length:	654	Species:	Saccharomyces cerevisiae

Alignment Length:	633	Identity:	304/633 - (48%)
Similarity:	423/633 - (66%)	Gaps:	26/633 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IGIDLGTTYSCVGVFQYGKV-EIIANDQGNRTTPSYVAFT-DSERLIGDAAKNQVAMNPKNSVFD 66
            ||||||||.|.|.:.: ||| :||.|.:|:|||||.|||| :.|||:|..||.|..:||:|::|.
Yeast    33 IGIDLGTTNSAVAIME-GKVPKIIENAEGSRTTPSVVAFTKEGERLVGIPAKRQAVVNPENTLFA 96

  Fly    67 AKRLIGRRFDDSKIQEDIKHWPFKVI-NDNGKPKISVEFKGANKCFSPEEISSMVLTKMKETAEA 130
            .||||||||:|:::|.|||..|:|:: :.||  ...||.:|  :.:||.:|...||.||||||||
Yeast    97 TKRLIGRRFEDAEVQRDIKQVPYKIVKHSNG--DAWVEARG--QTYSPAQIGGFVLNKMKETAEA 157

  Fly   131 YLGTTVKDAVITVPAYFNDSQRQATKDAGAIAGINVLRIINEPTAAALAYGLDKNLKGERNVLIF 195
            |||..||:||:||||||||||||||||||.|.|:||||::||||||||||||:|:  ..:.|.:|
Yeast   158 YLGKPVKNAVVTVPAYFNDSQRQATKDAGQIVGLNVLRVVNEPTAAALAYGLEKS--DSKVVAVF 220

  Fly   196 DLGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVNHFAEEFKRKYKKDLRSNPRALRR 260
            ||||||||:|||.||.| :|||:||.|||||||||||..|:......||.:...||.::..|::|
Yeast   221 DLGGGTFDISILDIDNG-VFEVKSTNGDTHLGGEDFDIYLLREIVSRFKTETGIDLENDRMAIQR 284

  Fly   261 LRTAAERAKRTLSS--STEASLEI---DALYEGHDFYSKVSRARFEELCGDLFRNTLEPVEKALK 320
            :|.|||:||..|||  |||.:|..   ||....| ...|.|||:||.|...|.:.|::||:||||
Yeast   285 IREAAEKAKIELSSTVSTEINLPFITADASGPKH-INMKFSRAQFETLTAPLVKRTVDPVKKALK 348

  Fly   321 DAKMDKSQIHDIVLVGGSTRIPKVQNLLQNFFGGKTLNLSINPDEAVAYGAAIQAAILSGDKSSE 385
            ||.:..|.|.:::||||.:|:|||...:::.| ||..:.::|||||||.|||:|.|:|||    |
Yeast   349 DAGLSTSDISEVLLVGGMSRMPKVVETVKSLF-GKDPSKAVNPDEAVAIGAAVQGAVLSG----E 408

  Fly   386 IKDVLLVDVAPLSLGIETAGGVMTKLIERNSRIPCKQSKTFTTYADNQPAVTIQVFEGERALTKD 450
            :.||||:||.||||||||.|||.|:||.||:.||.|:|:.|:|.|..|.:|.|:||:|||.|.:|
Yeast   409 VTDVLLLDVTPLSLGIETLGGVFTRLIPRNTTIPTKKSQIFSTAAAGQTSVEIRVFQGERELVRD 473

  Fly   451 NNVLGTFDLTGVPPAPRGVPKIDVTFDLDANGILNVTAKEQGTGNAKNITIKNDKGRLSQADIDR 515
            |.::|.|.|.|:||||:|||:|:||||:||:||:||:|:::.|....:||:....| ||:.:|::
Yeast   474 NKLIGNFTLAGIPPAPKGVPQIEVTFDIDADGIINVSARDKATNKDSSITVAGSSG-LSENEIEQ 537

  Fly   516 MLSEAEKYAEEDERHRQRIAARNQLETYLFGVKEAAENGGDRISAADKSSI---VERCSEAMKWL 577
            |:::|||:..:||..:|.|...|:.:......:.:.:....::..|:...:   :....|.:..:
Yeast   538 MVNDAEKFKSQDEARKQAIETANKADQLANDTENSLKEFEGKVDKAEAQKVRDQITSLKELVARV 602

  Fly   578 DSNTTAEKEEYEYKLKELEQFCSPIMTKMHKGGGDGQQAPNFGQQAGG 625
            ........||.:.|.:||:.....:..:::|...:.....|......|
Yeast   603 QGGEEVNAEELKTKTEELQTSSMKLFEQLYKNDSNNNNNNNGNNAESG 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp68	NP_524474.1	PTZ00009	2..635	CDD:240227	304/633 (48%)
Hsp68	NP_524474.1	HSPA1-2_6-8-like_NBD	3..379	CDD:212675	211/382 (55%)
SSC1	NP_012579.1	dnaK	30..633	CDD:234715	301/614 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810