DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp68 and SSQ1

DIOPT Version :9

Sequence 1:	NP_524474.1	Gene:	Hsp68 / 42852	FlyBaseID:	FBgn0001230	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_013473.1	Gene:	SSQ1 / 851084	SGDID:	S000004361	Length:	657	Species:	Saccharomyces cerevisiae

Alignment Length:	589	Identity:	259/589 - (43%)
Similarity:	383/589 - (65%)	Gaps:	39/589 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IGIDLGTTYSCVGVFQYG----KVEIIANDQGNRTTPSYVAF---------TDSERLIGDAAKNQ 55
            ||||||||.|.|...:..    ...||.||:|.|||||.|||         ...:.|:|.|||.|
Yeast    31 IGIDLGTTNSAVAYIRDSNDKKSATIIENDEGQRTTPSIVAFDVKSSPQNKDQMKTLVGMAAKRQ 95

  Fly    56 VAMNPKNSVFDAKRLIGRRFDDSKIQEDIKHWPFKVI--NDNGKPKISVEFKGANKCF-SPEEIS 117
            .|:|.:|:.|..||||||.|:|.::|.|:...|:|::  ..||:..:|.    :|... ||.:|:
Yeast    96 NAINSENTFFATKRLIGRAFNDKEVQRDMAVMPYKIVKCESNGQAYLST----SNGLIQSPSQIA 156

  Fly   118 SMVLTKMKETAEAYLGTTVKDAVITVPAYFNDSQRQATKDAGAIAGINVLRIINEPTAAALAYGL 182
            |::|..:|:|:|.|||..|..|||||||||||||||||||||.:||:||||:|||||||||::|:
Yeast   157 SILLKYLKQTSEEYLGEKVNLAVITVPAYFNDSQRQATKDAGKLAGLNVLRVINEPTAAALSFGI 221

  Fly   183 DKNLKGERN---VLIFDLGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVNHFAEEFK 244
            |    .:||   :.::||||||||:|||.|::| :||||:|.||||||||||||.:||:..:.|.
Yeast   222 D----DKRNNGLIAVYDLGGGTFDISILDIEDG-VFEVRATNGDTHLGGEDFDNVIVNYIIDTFI 281

  Fly   245 RK----YKKDLRSNPRALRRLRTAAERAKRTLSSSTEASLEIDALYEGHDFYSKVSRARFEELCG 305
            .:    .::::..|...::||:..:||||..||...:..:|:..:|:.......::....:.:..
Yeast   282 HENPEITREEITKNRETMQRLKDVSERAKIDLSHVKKTFIELPFVYKSKHLRVPMTEEELDNMTL 346

  Fly   306 DLFRNTLEPVEKALKDAKMDKSQIHDIVLVGGSTRIPKVQNLLQNFFGGKTLNLSINPDEAVAYG 370
            .|...|:.||::|||||.::...|.:::||||.||:||:::::::.| ||:.|.|:||||.||.|
Yeast   347 SLINRTIPPVKQALKDADIEPEDIDEVILVGGMTRMPKIRSVVKDLF-GKSPNSSVNPDETVALG 410

  Fly   371 AAIQAAILSGDKSSEIKDVLLVDVAPLSLGIETAGGVMTKLIERNSRIPCKQSKTFTTYADNQPA 435
            ||||..||||    |||:|||:||.||:|||||.||..:.||.||:.:|.|:::.|:|..|.|..
Yeast   411 AAIQGGILSG----EIKNVLLLDVTPLTLGIETFGGAFSPLIPRNTTVPVKKTEIFSTGVDGQAG 471

  Fly   436 VTIQVFEGERALTKDNNVLGTFDLTGVPPAPRGVPKIDVTFDLDANGILNVTAKEQGTGNAKNIT 500
            |.|:||:|||.|.::|.::|...|||:.|.|:|:|:|.||||:||:||:||:|.|:.:|..::||
Yeast   472 VDIKVFQGERGLVRNNKLIGDLKLTGITPLPKGIPQIYVTFDIDADGIINVSAAEKSSGKQQSIT 536

  Fly   501 IKNDKGRLSQADIDRMLSEAEKYAEEDERHRQRIAARNQLETYLFGVKEAAENGGDRISA-ADKS 564
            :..:.| ||:.:|.:::.||.....:|...|||:...::.:..:...:...:.....||: .:.|
Yeast   537 VIPNSG-LSEEEIAKLIEEANANRAQDNLIRQRLELISKADIMISDTENLFKRYEKLISSEKEYS 600

  Fly   565 SIVE 568
            :|||
Yeast   601 NIVE 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp68	NP_524474.1	PTZ00009	2..635	CDD:240227	259/589 (44%)
Hsp68	NP_524474.1	HSPA1-2_6-8-like_NBD	3..379	CDD:212675	180/397 (45%)
SSQ1	NP_013473.1	dnaK	29..656	CDD:234715	259/589 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810