Protein Alignment Hsp68 and hspa8

DIOPT Version :10

• Sequence 1: NP_524474.1
• Gene: Hsp68 / 42852
• FlyBaseID: FBgn0001230
• Length: 635
• Species: Drosophila melanogaster
• Sequence 2: NP_001103873.1
• Gene: hspa8 / 573376
• ZFINID: ZDB-GENE-990415-92
• Length: 649
• Species: Danio rerio
• Alignment Length: 646
• Identity: 461/646 - (71%)
• Similarity: 547/646 - (84%)
• Gaps: 13/646 - (2%)

  Fly     2 PAIGIDLGTTYSCVGVFQYGKVEIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPKNSVFD 66
            ||:|||||||||||||||:|||||||||||||||||||||||:||||||||||||||||.|:|||
Zfish     5 PAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTVFD 69

  Fly    67 AKRLIGRRFDDSKIQEDIKHWPFKVINDNGKPKISVEFKGANKCFSPEEISSMVLTKMKETAEAY 131
            |||||||||||..:|.|:|||||.|||||.:||:.||:||.:|.|.||||||||||||||.||||
Zfish    70 AKRLIGRRFDDGVVQSDMKHWPFNVINDNSRPKVQVEYKGESKSFYPEEISSMVLTKMKEIAEAY 134

  Fly   132 LGTTVKDAVITVPAYFNDSQRQATKDAGAIAGINVLRIINEPTAAALAYGLDKNLKGERNVLIFD 196
            ||.||.:|||||||||||||||||||||.|:|:|||||||||||||:||||||.:..||||||||
Zfish   135 LGKTVSNAVITVPAYFNDSQRQATKDAGTISGLNVLRIINEPTAAAIAYGLDKKVGAERNVLIFD 199

  Fly   197 LGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVNHFAEEFKRKYKKDLRSNPRALRRL 261
            |||||||||||||::| :|||:||||||||||||||||:||||..|||||:|||:..|.||:|||
Zfish   200 LGGGTFDVSILTIEDG-IFEVKSTAGDTHLGGEDFDNRMVNHFITEFKRKHKKDISDNKRAVRRL 263

  Fly   262 RTAAERAKRTLSSSTEASLEIDALYEGHDFYSKVSRARFEELCGDLFRNTLEPVEKALKDAKMDK 326
            |||.|||||||||||:||:|||:||||.|||:.::|||||||..||||.||:||||||:||||||
Zfish   264 RTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAKMDK 328

  Fly   327 SQIHDIVLVGGSTRIPKVQNLLQNFFGGKTLNLSINPDEAVAYGAAIQAAILSGDKSSEIKDVLL 391
            :||||||||||||||||:|.|||::|.||.||.|||||||||||||:||||||||||..::|:||
Zfish   329 AQIHDIVLVGGSTRIPKIQKLLQDYFNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQDLLL 393

  Fly   392 VDVAPLSLGIETAGGVMTKLIERNSRIPCKQSKTFTTYADNQPAVTIQVFEGERALTKDNNVLGT 456
            :||.||||||||||||||.||:||:.||.||::|||||:||||.|.|||:|||||:|||||:||.
Zfish   394 LDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLGK 458

  Fly   457 FDLTGVPPAPRGVPKIDVTFDLDANGILNVTAKEQGTGNAKNITIKNDKGRLSQADIDRMLSEAE 521
            |:|||:||||||||:|:||||:|||||:||:|.::.||....|||.|||||||:.||:||:.|||
Zfish   459 FELTGIPPAPRGVPQIEVTFDIDANGIMNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQEAE 523

  Fly   522 KYAEEDERHRQRIAARNQLETYLFGVKEAAENG--GDRISAADKSSIVERCSEAMKWLDSNTTAE 584
            ||..||:..|.:::|:|.||:|.|.:|...|:.  ..:||..||..|:::|:|.:.|||.|.|||
Zfish   524 KYKAEDDVQRDKVSAKNGLESYAFNMKSTVEDEKLKGKISDEDKQKILDKCNEVIGWLDKNQTAE 588

  Fly   585 KEEYEYKLKELEQFCSPIMTKMHKGGG-------DGQQA--PNFG-QQAGGYKGPTVEEVD 635
            :||:|::.||||:.|:||:||:::..|       :|...  |..| ...||..|||:||||
Zfish   589 REEFEHQQKELEKVCNPIITKLYQSAGGMPGGMPEGMPGGFPGAGAAPGGGSSGPTIEEVD 649

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp68	NP_524474.1	PTZ00009	2..635	CDD:240227	459/644 (71%)
hspa8	NP_001103873.1	PTZ00009	1..614	CDD:240227	448/609 (74%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142	2..386		312/381 (82%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142	394..509		82/114 (72%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	614..649		11/34 (32%)