Protein Alignment Hsp68 and HSPA14

DIOPT Version :10

• Sequence 1: NP_524474.1
• Gene: Hsp68 / 42852
• FlyBaseID: FBgn0001230
• Length: 635
• Species: Drosophila melanogaster
• Sequence 2: NP_057383.2
• Gene: HSPA14 / 51182
• HGNCID: 29526
• Length: 509
• Species: Homo sapiens
• Alignment Length: 508
• Identity: 181/508 - (35%)
• Similarity: 292/508 - (57%)
• Gaps: 8/508 - (1%)

  Fly     1 MPAIGIDLGTTYSCVGVFQYGKVEIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPKNSVF 65
            |.|||:.||.|.:||.|::.|:..::|||.|:|.||:.||::::|.::|.|||.....|..|:|.
Human     1 MAAIGVHLGCTSACVAVYKDGRAGVVANDAGDRVTPAVVAYSENEEIVGLAAKQSRIRNISNTVM 65

  Fly    66 DAKRLIGRRFDDSKIQEDIKHWPFKVINDNGKPKISVEFKGANKCFSPEEISSMVLTKMKETAEA 130
            ..|:::||...|.:.|:.|......||..|||.:..::.....|..:||:::.::.:||||||.:
Human    66 KVKQILGRSSSDPQAQKYIAESKCLVIEKNGKLRYEIDTGEETKFVNPEDVARLIFSKMKETAHS 130

  Fly   131 YLGTTVKDAVITVPAYFNDSQRQATKDAGAIAGINVLRIINEPTAAALAYGLDKNL-KGERNVLI 194
            .||:...|.|||||..|.:.|:.|..:|...||.||||:|:||:||.||||:.::. .|:.|:|:
Human   131 VLGSDANDVVITVPFDFGEKQKNALGEAARAAGFNVLRLIHEPSAALLAYGIGQDSPTGKSNILV 195

  Fly   195 FDLGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVNHFAEEFKRKYKKDLRSNPRALR 259
            |.|||.:..:|::.::.| ::.|.||..|.::||..|...|..:.|.||:|.:|.|:|.|.||:.
Human   196 FKLGGTSLSLSVMEVNSG-IYRVLSTNTDDNIGGAHFTETLAQYLASEFQRSFKHDVRGNARAMM 259

  Fly   260 RLRTAAERAKRTLSSSTEASLEIDALYEGHDFYSKVSRARFEELCGDLFRNTLEPVEKALKDAKM 324
            :|..:||.||.:||:...|:..:|:||||.||...|||||||.||..||...:|.:...|.....
Human   260 KLTNSAEVAKHSLSTLGSANCFLDSLYEGQDFDCNVSRARFELLCSPLFNKCIEAIRGLLDQNGF 324

  Fly   325 DKSQIHDIVLVGGSTRIPKVQNLLQNFFGGKTLNLSINPDEAVAYGAAIQAAILSGDKSSEIKDV 389
            ....|:.:||.|||:||||:|.|:::.|....|..||.|||.:..||||:|.||.|.::..::|.
Human   325 TADDINKVVLCGGSSRIPKLQQLIKDLFPAVELLNSIPPDEVIPIGAAIEAGILIGKENLLVEDS 389

  Fly   390 LLVDVAP---LSLGIETAGGV-MTKLIERNSRIPCKQSKTFTTYADNQPAVTIQVFEGE-RALTK 449
            |:::.:.   |..|::.:|.. .|.|....:.:|.::..|... ..:..:|.::::|.: :...|
Human   390 LMIECSARDILVKGVDESGASRFTVLFPSGTPLPARRQHTLQA-PGSISSVCLELYESDGKNSAK 453

  Fly   450 DNNVLGTFDLTGVPPAPRGVPKIDVTFDLDANGILNVTAKEQGTGNAKNITIK 502
            :........|..:.....|:..|.....:..:|.|:||..:|.||..:.|:|:
Human   454 EETKFAQVVLQDLDKKENGLRDILAVLTMKRDGSLHVTCTDQETGKCEAISIE 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp68	NP_524474.1	PTZ00009	2..635	CDD:240227	180/507 (36%)
HSPA14	NP_057383.2	ASKHA_NBD_HSP70_HSPA14	2..378	CDD:466836	153/376 (41%)