DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsp68 and Hspa14

DIOPT Version :9

Sequence 1:	NP_524474.1	Gene:	Hsp68 / 42852	FlyBaseID:	FBgn0001230	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_056580.2	Gene:	Hspa14 / 50497	MGIID:	1354164	Length:	509	Species:	Mus musculus

Alignment Length:	508	Identity:	179/508 - (35%)
Similarity:	291/508 - (57%)	Gaps:	8/508 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPAIGIDLGTTYSCVGVFQYGKVEIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPKNSVF 65
            |.|||:.||.|.:||.|::.|:.:::|||.|:|.||:.||:::.|:::|.|||.....:..::|.
Mouse     1 MAAIGVHLGCTSACVAVYKDGRADVVANDAGDRVTPAIVAYSEREQVVGLAAKQSRIRHVSSTVV 65

  Fly    66 DAKRLIGRRFDDSKIQEDIKHWPFKVINDNGKPKISVEFKGANKCFSPEEISSMVLTKMKETAEA 130
            ..|:::||...|.:.|:.|......||..|||.:..::.....|..:||:::.::.:||||||.:
Mouse    66 KVKQILGRSSADPQAQKYISESKCLVIEKNGKLRYEIDTGEETKLVNPEDVARLIFSKMKETAHS 130

  Fly   131 YLGTTVKDAVITVPAYFNDSQRQATKDAGAIAGINVLRIINEPTAAALAYGLDK-NLKGERNVLI 194
            .||:...|.|:|||..|.:.|:.|..:|...||.||||:|:||:||.||||:.: :..|:.|||:
Mouse   131 VLGSDANDVVVTVPFDFGEKQKSALGEAAGAAGFNVLRLIHEPSAALLAYGIGQDHPTGKSNVLV 195

  Fly   195 FDLGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVNHFAEEFKRKYKKDLRSNPRALR 259
            |.|||.:..:|::.::.| ::.|.||....::||..|.:.|..:.|.||:|.:|.|:|.|.||:.
Mouse   196 FKLGGTSLSLSVMEVNSG-MYRVLSTNTSDNIGGAHFTDTLAQYLASEFQRLFKHDVRGNARAMM 259

  Fly   260 RLRTAAERAKRTLSSSTEASLEIDALYEGHDFYSKVSRARFEELCGDLFRNTLEPVEKALKDAKM 324
            :|..:||.||.:||:...|:..:|:||||.||...|||||||.||..||....|.:.:.|:....
Mouse   260 KLMNSAEVAKHSLSTLGSANCFVDSLYEGQDFDCNVSRARFELLCSPLFNKCTEAIRELLRQTGF 324

  Fly   325 DKSQIHDIVLVGGSTRIPKVQNLLQNFFGGKTLNLSINPDEAVAYGAAIQAAILSGDKSSEIKDV 389
            ....|:.:||.|||:||||:|.|:::.|....|..||.|||.:..||||:|.||.|.:|:...|.
Mouse   325 TADDINKVVLCGGSSRIPKLQQLIKDLFPAVDLLNSIPPDEVIPIGAAIEAGILVGKESTSGDDS 389

  Fly   390 LLVDVAP---LSLGIETAGG-VMTKLIERNSRIPCKQSKTFTTYADNQPAVTIQVFEGE-RALTK 449
            ::::.:.   |..|::.:|. ..|.|....:.:|.::..|... .....:|.::::|.| :...|
Mouse   390 VMIECSAKDILVKGVDESGADRFTVLFPSGTPLPARRQHTLQA-PGRVSSVCLELYESEGKNSAK 453

  Fly   450 DNNVLGTFDLTGVPPAPRGVPKIDVTFDLDANGILNVTAKEQGTGNAKNITIK 502
            :........|..:.....|:..|.....:..:|.|.||..:|.||..:.||::
Mouse   454 EEAKFAQVVLQDLDKKENGLRDILAVLTMKRDGSLQVTCTDQDTGKCEAITVE 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp68	NP_524474.1	PTZ00009	2..635	CDD:240227	178/507 (35%)
Hsp68	NP_524474.1	HSPA1-2_6-8-like_NBD	3..379	CDD:212675	151/376 (40%)
Hspa14	NP_056580.2	HSPA14-like_NBD	2..376	CDD:212680	149/374 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810