DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsp68 and Hsc70-2

DIOPT Version :9

Sequence 1:	NP_524474.1	Gene:	Hsp68 / 42852	FlyBaseID:	FBgn0001230	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_524339.1	Gene:	Hsc70-2 / 41609	FlyBaseID:	FBgn0001217	Length:	633	Species:	Drosophila melanogaster

Alignment Length:	636	Identity:	473/636 - (74%)
Similarity:	551/636 - (86%)	Gaps:	8/636 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPAIGIDLGTTYSCVGVFQYGKVEIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPKNSVF 65
            :||||||||||||||||:|..||||||||||||||||||||.::||||||.||||||||.||:||
  Fly     4 IPAIGIDLGTTYSCVGVWQNSKVEIIANDQGNRTTPSYVAFNETERLIGDPAKNQVAMNAKNTVF 68

  Fly    66 DAKRLIGRRFDDSKIQEDIKHWPFKVINDNGKPKISVEFKGANKCFSPEEISSMVLTKMKETAEA 130
            ||||||||:|||.|||||:|.|||||||:.|||||.|||||..|.|:||||||||||||:|.||.
  Fly    69 DAKRLIGRKFDDKKIQEDLKLWPFKVINEKGKPKIEVEFKGERKRFAPEEISSMVLTKMREIAEV 133

  Fly   131 YLGTTVKDAVITVPAYFNDSQRQATKDAGAIAGINVLRIINEPTAAALAYGLDKNLKGERNVLIF 195
            |||..|||||:||||||||||||||||||:|||:|||||||||||||||||||||||||||||||
  Fly   134 YLGGKVKDAVVTVPAYFNDSQRQATKDAGSIAGLNVLRIINEPTAAALAYGLDKNLKGERNVLIF 198

  Fly   196 DLGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVNHFAEEFKRKYKKDLRSNPRALRR 260
            ||||||||||:|:|||||||||::|||||||||||||||||||||||||||:|.|::.|.|||||
  Fly   199 DLGGGTFDVSVLSIDEGSLFEVKATAGDTHLGGEDFDNRLVNHFAEEFKRKHKSDIKGNARALRR 263

  Fly   261 LRTAAERAKRTLSSSTEASLEIDALYEGHDFYSKVSRARFEELCGDLFRNTLEPVEKALKDAKMD 325
            ||||.||||||||||||||||||||:||.|||||:||||||||..||||:|::|||:||.|||||
  Fly   264 LRTACERAKRTLSSSTEASLEIDALHEGIDFYSKISRARFEELNMDLFRSTMQPVERALSDAKMD 328

  Fly   326 KSQIHDIVLVGGSTRIPKVQNLLQNFFGGKTLNLSINPDEAVAYGAAIQAAILSGDKSSEIKDVL 390
            |..|||:|||||||||||:|.|||:.||||.||||||||||||||||:|||||:|..||:|:|:|
  Fly   329 KKAIHDVVLVGGSTRIPKIQKLLQDLFGGKQLNLSINPDEAVAYGAAVQAAILTGVGSSQIQDLL 393

  Fly   391 LVDVAPLSLGIETAGGVMTKLIERNSRIPCKQSKTFTTYADNQPAVTIQVFEGERALTKDNNVLG 455
            |||||||||||||||||||.|:|||:||||||.:.||||:|||.||||||:|||||:|||||:||
  Fly   394 LVDVAPLSLGIETAGGVMTNLVERNARIPCKQQQIFTTYSDNQNAVTIQVYEGERAMTKDNNLLG 458

  Fly   456 TFDLTGVPPAPRGVPKIDVTFDLDANGILNVTAKEQGTGNAKNITIKNDKGRLSQADIDRMLSEA 520
            ||:|||:||||||||:|:|.|||:|:|||||.||:..||.::.|||.|||||||:|:||||||||
  Fly   459 TFNLTGIPPAPRGVPQIEVAFDLNADGILNVNAKDNSTGKSEKITISNDKGRLSKAEIDRMLSEA 523

  Fly   521 EKYAEEDERHRQRIAARNQLETYLFGVKEAAENGGDRI-SAADKSSIVERCSEAMKWLDSNTTAE 584
            |||..||:|.|:|:.::|.||.|::..::|.::....: |..::|.:.::||....|||.|:.||
  Fly   524 EKYKVEDDRQRERVQSKNNLEAYIYACRQAVDDAPSGVLSETERSKVRDKCSSEASWLDKNSLAE 588

  Fly   585 KEEYEYKLKELEQFCSPIMTKMHKGGGDGQQAPNFGQQAGGYKGPTVEEVD 635
            |||:|..|||.::.|:|||:|:| ||..|:.:...|..      |||||||
  Fly   589 KEEFESHLKECQRICTPIMSKIH-GGKKGKSSMGKGSH------PTVEEVD 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp68	NP_524474.1	PTZ00009	2..635	CDD:240227	471/633 (74%)
Hsp68	NP_524474.1	HSPA1-2_6-8-like_NBD	3..379	CDD:212675	317/375 (85%)
Hsc70-2	NP_524339.1	PTZ00009	1..632	CDD:240227	471/634 (74%)
Hsc70-2	NP_524339.1	HSPA1-2_6-8-like_NBD	6..382	CDD:212675	317/375 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440295
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Homologene	1	1.000	-	-		H74294
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D180577at33208
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	1	1.100	-	-	P	PTHR19375
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.750