DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsp68 and CG7182

DIOPT Version :9

Sequence 1:	NP_524474.1	Gene:	Hsp68 / 42852	FlyBaseID:	FBgn0001230	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_001286979.1	Gene:	CG7182 / 38944	FlyBaseID:	FBgn0035878	Length:	513	Species:	Drosophila melanogaster

Alignment Length:	512	Identity:	144/512 - (28%)
Similarity:	244/512 - (47%)	Gaps:	50/512 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PAIGIDLGTTYSCVG-VFQYGKVEIIANDQGNRTTPSYVAFTD-SERLIGDAAKNQVAMNPKNSV 64
            |..||.:|.:..|:. |...||.|:|||.||:|.:.:.:.:.. ||...|..||.::|..|:.:|
  Fly     3 PRFGIKIGNSTLCIAHVRADGKAEVIANKQGDRVSQACLLWDGASEIECGLTAKQKMANRPRQAV 67

  Fly    65 FDAKRLI--GRRFDDSKIQEDIKHWP---------FKVINDNGKPKISVEFKGANKCFSPEEISS 118
            ..:.:|:  .....:.|:...::..|         |::.:.....:...:.:...|..|..:::.
  Fly    68 AHSFQLLQPKEELTEEKLSSALREIPCDFDKEELVFRMEHTVPSDREDQDDRVVTKDLSAYQVTV 132

  Fly   119 MVLTKMKETAEAYL--GTTVKDAVITVPAYFNDSQRQATKDAGAIAGINVLRIINEPTAAALAYG 181
            .:|....|.|..|.  |.....||:::|:|:..|..:...||...||.:|.:||.|||||.|.|.
  Fly   133 ELLRAELELAHQYHTDGEQAPIAVLSIPSYYPASAYKLLADAAQTAGFHVAQIITEPTAAVLGYS 197

  Fly   182 L-DKNLKGERNVLIFDLGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVNHFAEEFKR 245
            : ::..:..|:||....||...|::..::..| ||...:|.|...:||..|...||....|||:|
  Fly   198 IGEEQTEQRRHVLTIKCGGLYSDIAFYSVQNG-LFVQLATFGPFPIGGRQFTEALVQFICEEFRR 261

  Fly   246 KYKKDLRSNPRALRRLRTAAERAKRTLSSSTEASLEIDALYEGHDFYSKVSRARFEELCGDLFRN 310
            |||.|...:.|::.::||||...|..|::.....|.||:|.:|.|:.:::||||||.|...:..|
  Fly   262 KYKLDPHESRRSVAKIRTAAANCKHILTTMPSTQLYIDSLMDGVDYNAQMSRARFESLIQPVINN 326

  Fly   311 TLEPVEKALKDAKMDK---SQIHDIVLVGGSTRIPKVQNLLQNFFGGKTLNLSINPDEAVAYGAA 372
            .::.:.:.::.|:.:.   |:|.||||:|.:.:|||:|..:...|....|:.|.:.||.||.|.|
  Fly   327 LIQQLGECVEQAQKEHPGLSKIDDIVLLGATMQIPKLQAAVGARFPDAKLHNSHSADEVVAIGCA 391

  Fly   373 IQAAILSGDKSSEI---------KDVLLV------DVAPLSLGIETAGGVMTKLIERNSRIPCKQ 422
            .||..|......::         :|.|.:      ..|.|.||   .|.|:...|    ||...|
  Fly   392 RQAVCLIDPLEQQLHKEEDCVVAEDDLFIWHGNDESNAKLVLG---RGSVLPAKI----RISLPQ 449

  Fly   423 SKTFTTYADNQPAVTIQVFEGERALTKDNNVLGTFDLTGVPPAPRGVPKIDVTFDLD 479
            |:.......::.|.:.::..||      :.:|.....:.:|  ..|:.:::|..|:|
  Fly   450 SEEGKGDDVSKAAASFKLRTGE------SEILARLPDSTIP--EDGLYQLEVEVDVD 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp68	NP_524474.1	PTZ00009	2..635	CDD:240227	144/512 (28%)
Hsp68	NP_524474.1	HSPA1-2_6-8-like_NBD	3..379	CDD:212675	120/394 (30%)
CG7182	NP_001286979.1	NBD_sugar-kinase_HSP70_actin	5..394	CDD:302596	118/389 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464186
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR19375
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840