DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsp68 and Hsc70-5

DIOPT Version :9

Sequence 1:	NP_524474.1	Gene:	Hsp68 / 42852	FlyBaseID:	FBgn0001230	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_001286414.1	Gene:	Hsc70-5 / 36583	FlyBaseID:	FBgn0001220	Length:	686	Species:	Drosophila melanogaster

Alignment Length:	601	Identity:	298/601 - (49%)
Similarity:	414/601 - (68%)	Gaps:	20/601 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IGIDLGTTYSCVGVFQYGKVEIIANDQGNRTTPSYVAFT-DSERLIGDAAKNQVAMNPKNSVFDA 67
            ||||||||.||:.|.:..:.::|.|.:|.|||||:|||| |.|||:|..||.|...|..|:.:..
  Fly    55 IGIDLGTTNSCLAVMEGKQAKVIENAEGARTTPSHVAFTKDGERLVGMPAKRQAVTNSANTFYAT 119

  Fly    68 KRLIGRRFDDSKIQEDIKHWPFKVIN-DNGKPKISVEFKGANKCFSPEEISSMVLTKMKETAEAY 131
            ||||||||||.::::||.:..:||:. .||...:|   ....|.:||.:|.:.:|.|||||||||
  Fly   120 KRLIGRRFDDPEVKKDITNLSYKVVKASNGDAWVS---STDGKVYSPSQIGAFILMKMKETAEAY 181

  Fly   132 LGTTVKDAVITVPAYFNDSQRQATKDAGAIAGINVLRIINEPTAAALAYGLDKNLKGERNVLIFD 196
            |.|.||:||:||||||||||||||||||.|||:||||:||||||||||||:||.  .::.:.::|
  Fly   182 LNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGMDKT--EDKIIAVYD 244

  Fly   197 LGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVNHFAEEFKRKYKKDLRSNPRALRRL 261
            |||||||:|||.|.:| :|||:||.|||.||||||||.:||....|||:....|:|.:..|::||
  Fly   245 LGGGTFDISILEIQKG-VFEVKSTNGDTLLGGEDFDNHIVNFLVAEFKKDSGIDIRKDNIAMQRL 308

  Fly   262 RTAAERAKRTLSSSTEAS-----LEIDALYEGHDFYSKVSRARFEELCGDLFRNTLEPVEKALKD 321
            :.|||:||..||||.:..     |.:||....| ...|::|::.|.|.|||.:.|::|.:|||.|
  Fly   309 KEAAEKAKCELSSSQQTDINLPYLTMDAAGPQH-MNLKLTRSKLESLVGDLIKRTIQPCQKALSD 372

  Fly   322 AKMDKSQIHDIVLVGGSTRIPKVQNLLQNFFGGKTLNLSINPDEAVAYGAAIQAAILSGDKSSEI 386
            |::.||:|.:::||||.||:||||:.:|..| |:..:.|:|||||||.|||:|..:|:||    :
  Fly   373 AEVSKSEIGEVLLVGGMTRMPKVQSTVQELF-GRQPSRSVNPDEAVAVGAAVQGGVLAGD----V 432

  Fly   387 KDVLLVDVAPLSLGIETAGGVMTKLIERNSRIPCKQSKTFTTYADNQPAVTIQVFEGERALTKDN 451
            .||||:||.||||||||.|||.|:||.||:.||.|:|:.|:|.:|.|..|.|:|.:|||.:..||
  Fly   433 TDVLLLDVTPLSLGIETLGGVFTRLISRNTTIPTKKSQVFSTASDGQTQVEIKVHQGEREMANDN 497

  Fly   452 NVLGTFDLTGVPPAPRGVPKIDVTFDLDANGILNVTAKEQGTGNAKNITIKNDKGRLSQADIDRM 516
            .:||:|.|.|:||||||||:|:|.||:|||||::|:||::|||..:.|.|:: .|.||:.:|:.|
  Fly   498 KLLGSFTLVGIPPAPRGVPQIEVVFDIDANGIVHVSAKDKGTGKEQQIVIQS-SGGLSKDEIENM 561

  Fly   517 LSEAEKYAEEDERHRQRIAARNQLETYLFGVKEAAENGGDRISAADKSSIVERCSEAMKWLDSNT 581
            :.:||:||..|::.|:.|...||.|:.:...:...|....::.|.:...:.:..::....|.:..
  Fly   562 IKKAEEYATADKQKRELIEIVNQGESIVHDTETKMEEFKSQLPAEECEKLKKEIADLRTLLANKE 626

  Fly   582 TAEKEEYEYKLKELEQ 597
            ||:.||.......|:|
  Fly   627 TADLEEVRKATSSLQQ 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp68	NP_524474.1	PTZ00009	2..635	CDD:240227	298/601 (50%)
Hsp68	NP_524474.1	HSPA1-2_6-8-like_NBD	3..379	CDD:212675	203/381 (53%)
Hsc70-5	NP_001286414.1	dnaK	51..666	CDD:234715	298/601 (50%)
		HSPA9-like_NBD	51..428	CDD:212683	203/380 (53%)
		Syntaphilin	<566..>642	CDD:291936	17/75 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464211
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D288077at2759
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR19375
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850