DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hsp68 and HSPA5

DIOPT Version :9

Sequence 1:NP_524474.1 Gene:Hsp68 / 42852 FlyBaseID:FBgn0001230 Length:635 Species:Drosophila melanogaster
Sequence 2:NP_005338.1 Gene:HSPA5 / 3309 HGNCID:5238 Length:654 Species:Homo sapiens


Alignment Length:624 Identity:374/624 - (59%)
Similarity:494/624 - (79%) Gaps:13/624 - (2%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 IGIDLGTTYSCVGVFQYGKVEIIANDQGNRTTPSYVAFT-DSERLIGDAAKNQVAMNPKNSVFDA 67
            :||||||||||||||:.|:|||||||||||.|||||||| :.|||||||||||:..||:|:||||
Human    31 VGIDLGTTYSCVGVFKNGRVEIIANDQGNRITPSYVAFTPEGERLIGDAAKNQLTSNPENTVFDA 95

  Fly    68 KRLIGRRFDDSKIQEDIKHWPFKVINDNGKPKISVEFKGA-NKCFSPEEISSMVLTKMKETAEAY 131
            ||||||.::|..:|:|||..||||:....||.|.|:..|. .|.|:|||||:|||||||||||||
Human    96 KRLIGRTWNDPSVQQDIKFLPFKVVEKKTKPYIQVDIGGGQTKTFAPEEISAMVLTKMKETAEAY 160

  Fly   132 LGTTVKDAVITVPAYFNDSQRQATKDAGAIAGINVLRIINEPTAAALAYGLDKNLKGERNVLIFD 196
            ||..|..||:||||||||:|||||||||.|||:||:||||||||||:||||||. :||:|:|:||
Human   161 LGKKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVMRIINEPTAAAIAYGLDKR-EGEKNILVFD 224

  Fly   197 LGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVNHFAEEFKRKYKKDLRSNPRALRRL 261
            |||||||||:||||.| :|||.:|.|||||||||||.|::.||.:.:|:|..||:|.:.||:::|
Human   225 LGGGTFDVSLLTIDNG-VFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKDVRKDNRAVQKL 288

  Fly   262 RTAAERAKRTLSSSTEASLEIDALYEGHDFYSKVSRARFEELCGDLFRNTLEPVEKALKDAKMDK 326
            |...|:|||.|||..:|.:||::.|||.||...::||:||||..||||:|::||:|.|:|:.:.|
Human   289 RREVEKAKRALSSQHQARIEIESFYEGEDFSETLTRAKFEELNMDLFRSTMKPVQKVLEDSDLKK 353

  Fly   327 SQIHDIVLVGGSTRIPKVQNLLQNFFGGKTLNLSINPDEAVAYGAAIQAAILSGDKSSEIKDVLL 391
            |.|.:||||||||||||:|.|::.||.||..:..||||||||||||:||.:||||:  :..|::|
Human   354 SDIDEIVLVGGSTRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGDQ--DTGDLVL 416

  Fly   392 VDVAPLSLGIETAGGVMTKLIERNSRIPCKQSKTFTTYADNQPAVTIQVFEGERALTKDNNVLGT 456
            :||.||:|||||.||||||||.||:.:|.|:|:.|:|.:||||.|||:|:||||.|||||::|||
Human   417 LDVCPLTLGIETVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVYEGERPLTKDNHLLGT 481

  Fly   457 FDLTGVPPAPRGVPKIDVTFDLDANGILNVTAKEQGTGNAKNITIKNDKGRLSQADIDRMLSEAE 521
            |||||:||||||||:|:|||::|.||||.|||:::||||...|||.||:.||:..:|:||:::||
Human   482 FDLTGIPPAPRGVPQIEVTFEIDVNGILRVTAEDKGTGNKNKITITNDQNRLTPEEIERMVNDAE 546

  Fly   522 KYAEEDERHRQRIAARNQLETYLFGVKEA---AENGGDRISAADKSSIVERCSEAMKWLDSNTTA 583
            |:||||::.::||..||:||:|.:.:|..   .|..|.::|:.||.::.:...|.::||:|:..|
Human   547 KFAEEDKKLKERIDTRNELESYAYSLKNQIGDKEKLGGKLSSEDKETMEKAVEEKIEWLESHQDA 611

  Fly   584 EKEEYEYKLKELEQFCSPIMTKMHKGGGDGQQAPNFGQQ 622
            :.|:::.|.||||:...||::|::...|    .|..|::
Human   612 DIEDFKAKKKELEEIVQPIISKLYGSAG----PPPTGEE 646

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hsp68NP_524474.1 PTZ00009 2..635 CDD:240227 374/624 (60%)
HSPA1-2_6-8-like_NBD 3..379 CDD:212675 248/376 (66%)
HSPA5NP_005338.1 Required for interaction with KIAA1324. /evidence=ECO:0000269|PubMed:26045166 1..80 40/48 (83%)
HSP70 30..635 CDD:394970 371/607 (61%)
Nucleotide-binding (NBD). /evidence=ECO:0000303|PubMed:28286085 125..280 110/156 (71%)
Interdomain linker. /evidence=ECO:0000250|UniProtKB:G3I8R9 409..419 2/11 (18%)
Substrate-binding (SBD). /evidence=ECO:0000303|PubMed:28286085 420..500 56/79 (71%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 633..654 4/18 (22%)
Prevents secretion from ER. /evidence=ECO:0000255 651..654
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0443
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53894
OrthoDB 1 1.010 - - D288077at2759
OrthoFinder 1 1.000 - - FOG0000049
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100083
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.730

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