Protein Alignment Hsp68 and HSPA4

DIOPT Version :9

• Sequence 1: NP_524474.1
• Gene: Hsp68 / 42852
• FlyBaseID: FBgn0001230
• Length: 635
• Species: Drosophila melanogaster
• Sequence 2: NP_002145.3
• Gene: HSPA4 / 3308
• HGNCID: 5237
• Length: 840
• Species: Homo sapiens
• Alignment Length: 825
• Identity: 223/825 - (27%)
• Similarity: 356/825 - (43%)
• Gaps: 210/825 - (25%)

  Fly     1 MPAIGIDLGTTYSCVGVFQYGKVEIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPKNSVF 65
            |..:|||||.....|.|.:.|.:|.|||:..:|.||:.::|....|.||.|||:||..|.||:|.
Human     1 MSVVGIDLGFQSCYVAVARAGGIETIANEYSDRCTPACISFGPKNRSIGAAAKSQVISNAKNTVQ 65

  Fly    66 DAKRLIGRRFDDSKIQEDIKHWPFKVIN-DNGKPKISVEFKGANKCFSPEEISSMVLTKMKETAE 129
            ..||..||.|.|..::.:..:..:.::. ..|...|.|.:....:.|:.|::::|:|:|:|||||
Human    66 GFKRFHGRAFSDPFVEAEKSNLAYDIVQLPTGLTGIKVTYMEEERNFTTEQVTAMLLSKLKETAE 130

  Fly   130 AYLGTTVKDAVITVPAYFNDSQRQATKDAGAIAGINVLRIINEPTAAALAYGLDKN-----LKGE 189
            :.|...|.|.|::||.::.|::|::..||..|||:|.||::||.||.|||||:.|.     .:..
Human   131 SVLKKPVVDCVVSVPCFYTDAERRSVMDATQIAGLNCLRLMNETTAVALAYGIYKQDLPALEEKP 195

  Fly   190 RNVLIFDLGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVNHFAEEFKRKYKKDLRSN 254
            |||:..|:|...:.||:...:.|.| :|.:||.||.|||..||..|||||.|||.:|||.|::|.
Human   196 RNVVFVDMGHSAYQVSVCAFNRGKL-KVLATAFDTTLGGRKFDEVLVNHFCEEFGKKYKLDIKSK 259

  Fly   255 PRALRRLRTAAERAKRTLS-SSTEASLEIDALYEGHDFYSKVSRARFEELCGDLFRNTLEPVEKA 318
            .|||.||....|:.|:.:| ::::..|.|:......|....::|.:|.|:|.||......|:...
Human   260 IRALLRLSQECEKLKKLMSANASDLPLSIECFMNDVDVSGTMNRGKFLEMCNDLLARVEPPLRSV 324

  Fly   319 LKDAKMDKSQIHDIVLVGGSTRIPKVQNLLQNFFGGKTLNLSINPDEAVAYGAAIQAAILSGDKS 383
            |:..|:.|..|:.:.:|||:||||.|:..:..|| ||.|:.::|.||||..|.|:|.||||  .:
Human   325 LEQTKLKKEDIYAVEIVGGATRIPAVKEKISKFF-GKELSTTLNADEAVTRGCALQCAILS--PA 386

  Fly   384 SEIKDVLLVDVAPLSLGIE-----TAGGVMTKLIERNSRIPCKQSKTFTTYADNQPAVTIQVFEG 443
            .::::..:.||.|..:.:.     ..|....::..:|...|.  ||..|.|. .:|......:..
Human   387 FKVREFSITDVVPYPISLRWNSPAEEGSSDCEVFSKNHAAPF--SKVLTFYR-KEPFTLEAYYSS 448

  Fly   444 ERALTKDNNVLGTFDLTGVPPAPRG-VPKIDVTFDLDANGILNVT-------------------- 487
            .:.|...:..:..|.:..|.|...| ..|:.|...::.:||.:|:
Human   449 PQDLPYPDPAIAQFSVQKVTPQSDGSSSKVKVKVRVNVHGIFSVSSASLVEVHKSEENEEPMETD 513

  Fly   488 --AKEQ-----------------------------------GTGNAK------------------ 497
              |||:                                   |:.:.|
Human   514 QNAKEEEKMQVDQEEPHVEEQQQQTPAENKAESEEMETSQAGSKDKKMDQPPQAKKAKVKTSTVD 578

  Fly   498 ----------------NITIKNDKGRLSQADI-------------------DRMLSEAEKYAEED 527
                            |:.|:|:...:.|..:                   |::..|.||:..||
Human   579 LPIENQLLWQIDREMLNLYIENEGKMIMQDKLEKERNDAKNAVEEYVYEMRDKLSGEYEKFVSED 643

  Fly   528 ERHR-----------------------------------QRIAAR---------------NQLET 542
            :|:.                                   |.|..|               .|::.
Human   644 DRNSFTLKLEDTENWLYEDGEDQPKQVYVDKLAELKNLGQPIKIRFQESEERPKLFEELGKQIQQ 708

  Fly   543 YLFGVK--EAAENGGDRISAADKSSIVERCSEAMKWLDS------------NTTAEKEEYEYKLK 593
            |:..:.  :..|:..|.:.|||.:.:.:..:|||:|:::            :...:.:|.|.|:|
Human   709 YMKIISSFKNKEDQYDHLDAADMTKVEKSTNEAMEWMNNKLNLQNKQSLTMDPVVKSKEIEAKIK 773

  Fly   594 ELEQFCSPIMTK---------------MHKGGGDGQQAPNFGQQA 623
            ||...||||::|               ...|..|| |..|.|.||
Human   774 ELTSTCSPIISKPKPKVEPPKEEQKNAEQNGPVDG-QGDNPGPQA 817

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp68	NP_524474.1	PTZ00009	2..635	CDD:240227	222/824 (27%)
		HSPA1-2_6-8-like_NBD	3..379	CDD:212675	150/382 (39%)
HSPA4	NP_002145.3	HSPA4_NBD	2..384	CDD:212687	150/383 (39%)
		HSP70	3..607	CDD:278441	181/610 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	500..575		5/74 (7%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	779..840		13/40 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810