DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsp68 and HSPA1B

DIOPT Version :9

Sequence 1:	NP_524474.1	Gene:	Hsp68 / 42852	FlyBaseID:	FBgn0001230	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_005337.2	Gene:	HSPA1B / 3304	HGNCID:	5233	Length:	641	Species:	Homo sapiens

Alignment Length:	641	Identity:	466/641 - (72%)
Similarity:	551/641 - (85%)	Gaps:	13/641 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 AIGIDLGTTYSCVGVFQYGKVEIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPKNSVFDA 67
            |||||||||||||||||:|||||||||||||||||||||||:|||||||||||||:||:|:||||
Human     6 AIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDA 70

  Fly    68 KRLIGRRFDDSKIQEDIKHWPFKVINDNGKPKISVEFKGANKCFSPEEISSMVLTKMKETAEAYL 132
            ||||||:|.|..:|.|:|||||:||||..|||:.|.:||..|.|.||||||||||||||.|||||
Human    71 KRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYL 135

  Fly   133 GTTVKDAVITVPAYFNDSQRQATKDAGAIAGINVLRIINEPTAAALAYGLDKNLKGERNVLIFDL 197
            |..|.:|||||||||||||||||||||.|||:|||||||||||||:|||||:..|||||||||||
Human   136 GYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDL 200

  Fly   198 GGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVNHFAEEFKRKYKKDLRSNPRALRRLR 262
            |||||||||||||:| :|||::||||||||||||||||||||.||||||:|||:..|.||:||||
Human   201 GGGTFDVSILTIDDG-IFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLR 264

  Fly   263 TAAERAKRTLSSSTEASLEIDALYEGHDFYSKVSRARFEELCGDLFRNTLEPVEKALKDAKMDKS 327
            ||.|||||||||||:||||||:|:||.|||:.::||||||||.||||:|||||||||:|||:||:
Human   265 TACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKA 329

  Fly   328 QIHDIVLVGGSTRIPKVQNLLQNFFGGKTLNLSINPDEAVAYGAAIQAAILSGDKSSEIKDVLLV 392
            ||||:|||||||||||||.|||:||.|:.||.|||||||||||||:|||||.||||..::|:||:
Human   330 QIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLL 394

  Fly   393 DVAPLSLGIETAGGVMTKLIERNSRIPCKQSKTFTTYADNQPAVTIQVFEGERALTKDNNVLGTF 457
            ||||||||:||||||||.||:|||.||.||::.||||:||||.|.|||:|||||:|||||:||.|
Human   395 DVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRF 459

  Fly   458 DLTGVPPAPRGVPKIDVTFDLDANGILNVTAKEQGTGNAKNITIKNDKGRLSQADIDRMLSEAEK 522
            :|:|:||||||||:|:||||:||||||||||.::.||.|..|||.|||||||:.:|:||:.||||
Human   460 ELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEK 524

  Fly   523 YAEEDERHRQRIAARNQLETYLFGVKEAAENGG--DRISAADKSSIVERCSEAMKWLDSNTTAEK 585
            |..|||..|:|::|:|.||:|.|.:|.|.|:.|  .:||.|||..::::|.|.:.|||:||.|||
Human   525 YKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEK 589

  Fly   586 EEYEYKLKELEQFCSPIMTKMHKG------GGDGQQAPNFGQQAGGYKGPTVEEVD 635
            :|:|:|.|||||.|:||::.:::|      ||.|.|.|    :.|...|||:||||
Human   590 DEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGP----KGGSGSGPTIEEVD 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp68	NP_524474.1	PTZ00009	2..635	CDD:240227	464/639 (73%)
Hsp68	NP_524474.1	HSPA1-2_6-8-like_NBD	3..379	CDD:212675	307/375 (82%)
HSPA1B	NP_005337.2	PTZ00009	1..611	CDD:240227	452/605 (75%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250\|UniProtKB:P11142	2..386		311/380 (82%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250\|UniProtKB:P11142	394..509		84/114 (74%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	614..641		11/30 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H74294
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53894
OrthoDB	1	1.010	-	-		D180577at33208
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	1	1.100	-	-	O	PTHR19375
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.830