DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsp68 and hyou1

DIOPT Version :9

Sequence 1:	NP_524474.1	Gene:	Hsp68 / 42852	FlyBaseID:	FBgn0001230	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_997868.1	Gene:	hyou1 / 327133	ZFINID:	ZDB-GENE-030131-5344	Length:	980	Species:	Danio rerio

Alignment Length:	742	Identity:	221/742 - (29%)
Similarity:	344/742 - (46%)	Gaps:	156/742 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IGIDLGTTYSCVGVFQYG-KVEIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPKNSVFDA 67
            :.:|||:.:..|.:.:.| .:||:.|.:..|.||..|...::|||.||.|......|||......
Zfish    28 MSVDLGSEWMKVAIVKPGVPMEIVLNKESRRKTPVAVCLKENERLFGDGALGVAVKNPKVVYRFL 92

  Fly    68 KRLIGRRFDDSKIQEDIKHWPFKVINDNGKPKISVEFKGANKC-FSPEEISSMVLTKMKETAEAY 131
            :.::|:..|:.::.|..||:|...:..:.| :.:|.||.:.:. ::|||:..|:|...:..|:.:
Zfish    93 QSILGKTADNPQVAEYQKHFPEHQLQKDEK-RGTVYFKFSEEMQYTPEELLGMILNYSRTLAQDF 156

  Fly   132 LGTTVKDAVITVPAYFNDSQRQATKDAGAIAGINVLRIINEPTAAALAYGL----DKNLKGERNV 192
            ....:||||||||||||.::|:|...|..|||:.||::||:.||.||.||:    |.|...: |:
Zfish   157 AEQPIKDAVITVPAYFNQAERRAVLQAAHIAGLKVLQLINDNTAVALNYGVFRRKDINSTAQ-NI 220

  Fly   193 LIFDLGGGTFDVSILTI------DEGS--LFEVRSTAGDTHLGGEDFDNRLVNHFAEEF--KRKY 247
            :.:|:|.|:...:|:|.      :.|:  ..::|....|..|||.:.:.||.:|.|:.|  ::|.
Zfish   221 MFYDMGSGSTTATIVTYQTVKTKESGTQPQLQIRGVGFDRTLGGFEMELRLRDHLAKLFNEQKKS 285

  Fly   248 KKDLRSNPRALRRLRTAAERAKRTLSSSTEASLEIDALYEGHDFYSKVSRARFEELCGDLFRNTL 312
            |||:|.|.||:.:|...|:|.|..||::.|.:.:|:.|.:..||.:||:|:.||.||.|||....
Zfish   286 KKDVRDNLRAMAKLLKEAQRLKTVLSANAEHTAQIEGLMDDIDFKAKVTRSEFEALCEDLFDRVP 350

  Fly   313 EPVEKALKDAKMDKSQIHDIVLVGGSTRIPKVQNLLQNFFGGKTLNLSINPDEAVAYGAAIQAAI 377
            .||::||..|:|...:|..::||||:||:||||::|....|.:.|:.:||.|||.|.||..|||.
Zfish   351 GPVKQALAAAEMSMDEIEQVILVGGATRVPKVQDVLLKSVGKEELSKNINADEAAAMGAVYQAAA 415

  Fly   378 LSGDKSSEIKDVLLVDVAPLSLGIETA------GGVMTKLIERNSRI------PCKQSK--TFTT 428
            ||  |:.::|..|:.|.|...:.:|.:      .||  |.::.|.||      |..|.|  ||..
Zfish   416 LS--KAFKVKPFLVRDAAVFPIQVEFSRETEEEDGV--KSLKHNKRILFQRMAPYPQRKVITFNR 476

  Fly   429 YADNQPAVTIQVFEGERAL--TKDNNVLGTFDLTGVPPAPRGVPK------------IDVTFDLD 479
            |.|:   ....:..|:.:.  .:|..|.|:.:||.|..:  ||..            |...|::|
Zfish   477 YIDD---FVFYINYGDLSFLSEQDMKVFGSQNLTTVKLS--GVGSSFKKHSDAESKGIKAHFNMD 536

  Fly   480 ANGIL------------------------------------------NVT-------------AK 489
            .:|:|                                          |||             .|
Zfish   537 ESGVLILDRVESVFETIVEEKEEESTLTKLGNTISSLFGGGSSEPSANVTEPVTDEEEVTPEAGK 601

  Fly   490 EQGTGNAKNITI----KNDKGRLSQADIDRMLSEAEKYAEEDERHRQRIAARNQLETYLFGVKEA 550
            ||.....:..|:    :.::|:           |||..|||.:..:::  |.||.||.....::.
Zfish   602 EQDQPEKQEETVQEKPETEEGK-----------EAEPQAEEQKEDKEK--AENQGETESEKTEKP 653

  Fly   551 AENGGDRISAAD-------KSSI-----------------VERCSEAMKWLDSNT--TAEKEEYE 589
            .|...|....||       ||.|                 .|....:.|.|...|  ..||:|.|
Zfish   654 EEKTTDEEKEADMKPKLQKKSKISADIAVELEVNDVLDPSAEDMEGSKKKLQDLTDRDLEKQERE 718

  Fly   590 YKLKELEQFCSPIMTKMHKGGGDGQQA 616
            ..|..||.|......|:::   |..||
Zfish   719 KTLNSLEAFIFETQDKLYQ---DEYQA 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp68	NP_524474.1	PTZ00009	2..635	CDD:240227	221/742 (30%)
Hsp68	NP_524474.1	HSPA1-2_6-8-like_NBD	3..379	CDD:212675	144/390 (37%)
hyou1	NP_997868.1	HSP70	27..705	CDD:278441	207/700 (30%)
		HYOU1-like_NBD	28..414	CDD:212672	142/387 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	558..682		26/136 (19%)
		PTPRCAP	<598..>648	CDD:292341	16/62 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	894..980
		Prevents secretion from ER. /evidence=ECO:0000255	977..980
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810