DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp68 and Hspa14

DIOPT Version :9

Sequence 1:	NP_524474.1	Gene:	Hsp68 / 42852	FlyBaseID:	FBgn0001230	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_001004257.1	Gene:	Hspa14 / 307133	RGDID:	1303296	Length:	509	Species:	Rattus norvegicus

Alignment Length:	509	Identity:	184/509 - (36%)
Similarity:	295/509 - (57%)	Gaps:	10/509 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPAIGIDLGTTYSCVGVFQYGKVEIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPKNSVF 65
            |.|||:.||.|.:||.|::.|:.:::|||.|:|.||:.||:::.|:::|.|||.....|..::|.
  Rat     1 MAAIGVHLGCTSACVAVYKDGRADVVANDAGDRVTPAVVAYSEREQVVGLAAKQSRIRNISSTVV 65

  Fly    66 DAKRLIGRRFDDSKIQEDIKHWPFKVINDNGKPKISVEFKGANKCFSPEEISSMVLTKMKETAEA 130
            ..|:::||...|.:.|:.|......||..|||.:..::.....|..|||:::.::.:||||||.:
  Rat    66 KVKQILGRSTADPQAQKYISESKCLVIEKNGKLQYEIDTGEETKLVSPEDVARLIFSKMKETAHS 130

  Fly   131 YLGTTVKDAVITVPAYFNDSQRQATKDAGAIAGINVLRIINEPTAAALAYGLDKNL-KGERNVLI 194
            .||:...|.|:|||..|.:.|:.|..:|...||.||||:|:||:||.||||:.::. .|:.|||:
  Rat   131 VLGSDANDVVVTVPFDFGEKQKSALGEAAGAAGFNVLRLIHEPSAALLAYGIGQDCPTGKSNVLV 195

  Fly   195 FDLGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVNHFAEEFKRKYKKDLRSNPRALR 259
            |.|||.:..:||:.::.| ::.|.||....::||..|.:.|..:.|.||:|.:|.|:|.:.||:.
  Rat   196 FKLGGTSLSLSIMEVNSG-MYRVLSTNTSDNIGGVHFTDSLAQYLASEFQRLFKHDVRGSARAMM 259

  Fly   260 RLRTAAERAKRTLSSSTEASLEIDALYEGHDFYSKVSRARFEELCGDLFRNTLEPVEKALKDAKM 324
            :|..:||.||.:||:...|:..:|:||||.||...|||||||.||..||...:|.|...|:.:..
  Rat   260 KLMNSAEVAKHSLSTLGSANCFVDSLYEGQDFDCNVSRARFELLCSPLFNKCIEAVRALLQQSGF 324

  Fly   325 DKSQIHDIVLVGGSTRIPKVQNLLQNFF-GGKTLNLSINPDEAVAYGAAIQAAILSGDKSSEIKD 388
            ....|:.:||.|||:|||::|.|:::.| .|..|| ||.|||.:..||||:|.||.|.:|:...|
  Rat   325 TADDINKVVLCGGSSRIPRLQQLIKDLFPAGDLLN-SIPPDEVIPIGAAIEAGILVGKESTSGDD 388

  Fly   389 VLLVDVAP---LSLGIETAG-GVMTKLIERNSRIPCKQSKTFTTYADNQPAVTIQVFEGE-RALT 448
            .:|::.:.   |..|::.:| ...|.|....:.:|.::..|... ..:..:|.::::|.| :...
  Rat   389 SVLIECSARDILVKGVDESGANRFTVLFPSGTPLPARRQHTLQA-PGSISSVCLELYESEGKNSV 452

  Fly   449 KDNNVLGTFDLTGVPPAPRGVPKIDVTFDLDANGILNVTAKEQGTGNAKNITIK 502
            |:........|..:.....|:..|.....:..:|.|.||..:|.||..:.||::
  Rat   453 KEETKFAQVVLQDLDKKENGLRDILAVLTMKRDGSLQVTCTDQETGKCEAITVE 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp68	NP_524474.1	PTZ00009	2..635	CDD:240227	183/508 (36%)
Hsp68	NP_524474.1	HSPA1-2_6-8-like_NBD	3..379	CDD:212675	155/377 (41%)
Hspa14	NP_001004257.1	HSPA14-like_NBD	2..376	CDD:212680	153/375 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810