DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp68 and Hsph1

DIOPT Version :9

Sequence 1:	NP_524474.1	Gene:	Hsp68 / 42852	FlyBaseID:	FBgn0001230	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_001011901.1	Gene:	Hsph1 / 288444	RGDID:	1311609	Length:	858	Species:	Rattus norvegicus

Alignment Length:	813	Identity:	226/813 - (27%)
Similarity:	357/813 - (43%)	Gaps:	218/813 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPAIGIDLGTTYSCVGVFQYGKVEIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPKNSVF 65
            |..:|:|:|:....:.|.:.|.:|.|||:..:|.|||.::|....|.||.|||||...:..|:|.
  Rat     1 MSVVGLDVGSQSCYIAVARAGGIETIANEFSDRCTPSVISFGPKNRTIGVAAKNQQITHANNTVS 65

  Fly    66 DAKRLIGRRFDDSKIQEDIKHWPFKVI-NDNGKPKISVEFKGANKCFSPEEISSMVLTKMKETAE 129
            ..||..||.|:|..||::.::..:.:: ..||...|.|.:...:..||.|:|::|:|||:|||||
  Rat    66 SFKRFHGRAFNDPFIQKEKENLSYDLVPMKNGGVGIKVMYMDEDHLFSVEQITAMLLTKLKETAE 130

  Fly   130 AYLGTTVKDAVITVPAYFNDSQRQATKDAGAIAGINVLRIINEPTAAALAYGLDK----NLKGER 190
            ..|...|.|.||:||::|.|::|::..||..|.|:|.||::|:.||.||.||:.|    |...:.
  Rat   131 NNLKKPVTDCVISVPSFFTDAERRSVLDAAQIVGLNCLRLMNDMTAVALNYGIYKQDLPNADEKP 195

  Fly   191 NVLIF-DLGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVNHFAEEFKRKYKKDLRSN 254
            .|::| |:|..:|.||....::|.| :|..||.|..|||::||.:||.||..|||.|||.|.:|.
  Rat   196 RVVVFVDMGHSSFQVSACAFNKGKL-KVLGTAFDPFLGGKNFDEKLVEHFCAEFKTKYKLDAKSK 259

  Fly   255 PRALRRLRTAAERAKRTLSS-STEASLEIDALYEGHDFYSKVSRARFEELCGDLFRNTLEPVEKA 318
            .|||.||....|:.|:.:|| ||:..|.|:......|..:|::|::|||||.:|.:....|:...
  Rat   260 IRALLRLHQECEKLKKLMSSNSTDLPLNIECFMNDKDVSAKMNRSQFEELCAELLQKIEVPLHLL 324

  Fly   319 LKDAKMDKSQIHDIVLVGGSTRIPKVQNLLQNFFGGKTLNLSINPDEAVAYGAAIQAAILSGDKS 383
            ::...:...::..|.:|||:||||.|:..:..|| ||.::.::|.|||||.|.|:|.||||  .:
  Rat   325 MEQTHLKTEEVSAIEIVGGATRIPAVKERIARFF-GKDVSTTLNADEAVARGCALQCAILS--PA 386

  Fly   384 SEIKDVLLVDVAPLSLGI-------ETAGGVMTKLIERNSRIPCKQSKTF---------TTYADN 432
            .::::..:.|..|..:.:       ||.|  :.::..||...|..:..||         ..|:|.
  Rat   387 FKVREFSVTDAVPFPISLVWNHDSEETEG--VHEVFSRNHAAPFSKVLTFLRRGPFELEAFYSDP 449

  Fly   433 Q----PAVTIQVF---------EGERALTK----------------------------------- 449
            |    |...|..|         :||::..|
  Rat   450 QAVPYPEAKIGRFVVQNVSAQKDGEKSKVKVKVRVNTHGIFTISTASMVEKVPTEEEDGSSVEAD 514

  Fly   450 --------------------DNNVLGT--------FDLTGVPPAPR------------------- 467
                                ||:..||        ...:..||:|.
  Rat   515 MECPNQKPAESSDVDKNIQQDNSEAGTQPQVQTDGQQTSQSPPSPELTSEENKIPDADKANEKKV 579

  Fly   468 ------GVPKI---DVTFDLDAN-------GILNVTAKEQG-----------TGNAKN------- 498
                  ..|||   :|...::||       .:||:..:.:|           ..:|||
  Rat   580 DQPPEAKKPKIKVVNVELPVEANLVWQLGRDLLNMYIETEGKMIMQDKLEKERNDAKNAVEECVY 644

  Fly   499 -------------------------ITIKND------KGRLSQADIDRMLSEAEK--------YA 524
                                     :|...|      :.:..||.||: |.|..|        :.
  Rat   645 EFRDKLCGPYEKFICEQEHEKFLRLLTETEDWLYEEGEDQAKQAYIDK-LEELMKMGTPVKVRFQ 708

  Fly   525 EEDERHRQRIAARNQLETYLFGVKEAAENGG-----DRISAADKSSIVERCSEAMKWLDS--NTT 582
            |.:||.|.......:|:.|   .|.||:..|     :.|..::...:.:..:|.|:|:::  |..
  Rat   709 EAEERPRVLEELGQRLQHY---AKIAADFRGKDEKYNHIDESEMKKVEKSVNEVMEWMNNVMNAQ 770

  Fly   583 AEK----------EEYEYKLKELEQFCSPIMTK 605
            |::          .|...|:|||...|.|::|:
  Rat   771 AKRSLHQDPVVRTHEISAKVKELNNVCEPVVTQ 803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp68	NP_524474.1	PTZ00009	2..635	CDD:240227	225/812 (28%)
Hsp68	NP_524474.1	HSPA1-2_6-8-like_NBD	3..379	CDD:212675	152/382 (40%)
Hsph1	NP_001011901.1	HSPH1_NBD	2..384	CDD:212689	152/383 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..585		7/84 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	801..858		1/3 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810