DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp68 and Hspa4

DIOPT Version :9

Sequence 1:	NP_524474.1	Gene:	Hsp68 / 42852	FlyBaseID:	FBgn0001230	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_705893.1	Gene:	Hspa4 / 266759	RGDID:	628878	Length:	840	Species:	Rattus norvegicus

Alignment Length:	815	Identity:	221/815 - (27%)
Similarity:	358/815 - (43%)	Gaps:	194/815 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPAIGIDLGTTYSCVGVFQYGKVEIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPKNSVF 65
            |..:|||||.....|.|.:.|.:|.|||:..:|.||:.|:|....|.:|.|||:||..|.||:|.
  Rat     1 MSVVGIDLGFQSCYVAVARAGGIETIANEYSDRCTPACVSFGPKNRSVGAAAKSQVISNAKNTVQ 65

  Fly    66 DAKRLIGRRFDDSKIQEDIKHWPFKVIN-DNGKPKISVEFKGANKCFSPEEISSMVLTKMKETAE 129
            ..||..||.|.|..::.:..:..:.::. ..|...|.|.:....:.|:.|::::|:|:|:|||||
  Rat    66 GFKRFHGRAFSDPFVEAEKSNLAYDIVQLPTGLTGIKVTYMEEERNFTTEQVTAMLLSKLKETAE 130

  Fly   130 AYLGTTVKDAVITVPAYFNDSQRQATKDAGAIAGINVLRIINEPTAAALAYGLDKN-----LKGE 189
            :.|...|.|.|::||:::.|::|::..||..|||:|.||::||.||.|||||:.|.     .:..
  Rat   131 SVLKKPVVDCVVSVPSFYTDAERRSVMDATQIAGLNCLRLMNETTAVALAYGIYKQDLPALEEKP 195

  Fly   190 RNVLIFDLGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVNHFAEEFKRKYKKDLRSN 254
            |||:..|:|...:.||:...:.|.| :|.:||.||.|||..||..|||||.|||.:|||.|::|.
  Rat   196 RNVVFVDMGHSAYQVSVCAFNRGKL-KVLATAFDTTLGGRKFDEVLVNHFCEEFGKKYKLDIKSK 259

  Fly   255 PRALRRLRTAAERAKRTLS-SSTEASLEIDALYEGHDFYSKVSRARFEELCGDLFRNTLEPVEKA 318
            .|||.||....|:.|:.:| ::::..|.|:......|....::|.:|.|:|.||......|:...
  Rat   260 VRALLRLSQECEKLKKLMSANASDLPLSIECFMNDIDVSGTMNRGKFLEMCDDLLARVEPPLRSI 324

  Fly   319 LKDAKMDKSQIHDIVLVGGSTRIPKVQNLLQNFFGGKTLNLSINPDEAVAYGAAIQAAILSGDKS 383
            |..:|:.|..|:.:.:|||:||||.|:..:..|| ||.|:.::|.||||..|.|:|.||||  .:
  Rat   325 LDQSKLKKEDIYAVEIVGGATRIPAVKEKISKFF-GKELSTTLNADEAVTRGCALQCAILS--PA 386

  Fly   384 SEIKDVLLVDVAPLSLGIE-----TAGGVMTKLIERNSRIPCKQSKTFTTYADNQPAVTIQVFEG 443
            .::::..:.||.|..:.:.     ..|....::..:|...|.  ||..|.|. .:|......:..
  Rat   387 FKVREFSITDVVPYPISLRWNSPAEEGSSDCEVFPKNHAAPF--SKVLTFYR-KEPFTLEAYYSS 448

  Fly   444 ERALTKDNNVLGTFDLTGVPPAPRG-VPKIDVTFDLDANGILNVT-------------------- 487
            .:.|...:..:..|.:..|.|...| ..|:.|...::.:||.:|:
  Rat   449 PQDLPYPDPAIAQFSVQKVTPQSDGSSSKVKVKVRVNVHGIFSVSSAALVEVHKSEESEEPMETD 513

  Fly   488 --AKEQ-----------------------------------GTGN--------AKNITIK----- 502
              |||:                                   |:.:        ||...:|
  Rat   514 QNAKEEEKMQVDQEEPHTEEQQPQTPAENKAESEEMETSQAGSKDKKMDQPPQAKKAKVKTSTVD 578

  Fly   503 --------------------NDKGRLSQAD--------------------IDRMLSEAEKYAEED 527
                                .::|::...|                    .|::..|.||:..||
  Rat   579 LPIESQLLWQLDREMLGLYTENEGKMIMQDKLEKERNDAKNAVEEYVYEMRDKLSGEYEKFVSED 643

  Fly   528 ERHR-----------------------------------QRIAAR---------------NQLET 542
            :|:.                                   |.|..|               .|::.
  Rat   644 DRNNFTLKLEDTENWLYEDGEDQPKQVYVDKLAELRTLGQPIKTRFQESEERPKLFEELGKQIQQ 708

  Fly   543 YLFGVK--EAAENGGDRISAADKSSIVERCSEAMKWLDS--------NTTAE----KEEYEYKLK 593
            |:..:.  :..|:..:.:.|||.:.:.:..:|||:|::|        :.||:    .:|.|.|:|
  Rat   709 YMKVISSFKNKEDQYEHLDAADMTKVEKSTNEAMEWMNSKLNLQNKQSLTADPVVKTKEIEAKIK 773

  Fly   594 ELEQFCSPIMTKMHKGGGDGQQAPNFGQQAGGYKG 628
            ||...||||::|........::.|...:|.|...|
  Rat   774 ELTNICSPIISKPKPKVEPPKEEPKHAEQNGPVDG 808

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp68	NP_524474.1	PTZ00009	2..635	CDD:240227	220/814 (27%)
Hsp68	NP_524474.1	HSPA1-2_6-8-like_NBD	3..379	CDD:212675	150/382 (39%)
Hspa4	NP_705893.1	HSPA4_NBD	2..384	CDD:212687	150/383 (39%)
		PTZ00121	<499..743	CDD:173412	27/243 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..575		7/74 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	781..840		7/28 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810