Protein Alignment Hsp68 and Hspa4

DIOPT Version :10

• Sequence 1: NP_524474.1
• Gene: Hsp68 / 42852
• FlyBaseID: FBgn0001230
• Length: 635
• Species: Drosophila melanogaster
• Sequence 2: NP_705893.1
• Gene: Hspa4 / 266759
• RGDID: 628878
• Length: 840
• Species: Rattus norvegicus
• Alignment Length: 815
• Identity: 221/815 - (27%)
• Similarity: 358/815 - (43%)
• Gaps: 194/815 - (23%)

  Fly     1 MPAIGIDLGTTYSCVGVFQYGKVEIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPKNSVF 65
            |..:|||||.....|.|.:.|.:|.|||:..:|.||:.|:|....|.:|.|||:||..|.||:|.
  Rat     1 MSVVGIDLGFQSCYVAVARAGGIETIANEYSDRCTPACVSFGPKNRSVGAAAKSQVISNAKNTVQ 65

  Fly    66 DAKRLIGRRFDDSKIQEDIKHWPFKVIN-DNGKPKISVEFKGANKCFSPEEISSMVLTKMKETAE 129
            ..||..||.|.|..::.:..:..:.::. ..|...|.|.:....:.|:.|::::|:|:|:|||||
  Rat    66 GFKRFHGRAFSDPFVEAEKSNLAYDIVQLPTGLTGIKVTYMEEERNFTTEQVTAMLLSKLKETAE 130

  Fly   130 AYLGTTVKDAVITVPAYFNDSQRQATKDAGAIAGINVLRIINEPTAAALAYGLDKN-----LKGE 189
            :.|...|.|.|::||:::.|::|::..||..|||:|.||::||.||.|||||:.|.     .:..
  Rat   131 SVLKKPVVDCVVSVPSFYTDAERRSVMDATQIAGLNCLRLMNETTAVALAYGIYKQDLPALEEKP 195

  Fly   190 RNVLIFDLGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVNHFAEEFKRKYKKDLRSN 254
            |||:..|:|...:.||:...:.|.| :|.:||.||.|||..||..|||||.|||.:|||.|::|.
  Rat   196 RNVVFVDMGHSAYQVSVCAFNRGKL-KVLATAFDTTLGGRKFDEVLVNHFCEEFGKKYKLDIKSK 259

  Fly   255 PRALRRLRTAAERAKRTLS-SSTEASLEIDALYEGHDFYSKVSRARFEELCGDLFRNTLEPVEKA 318
            .|||.||....|:.|:.:| ::::..|.|:......|....::|.:|.|:|.||......|:...
  Rat   260 VRALLRLSQECEKLKKLMSANASDLPLSIECFMNDIDVSGTMNRGKFLEMCDDLLARVEPPLRSI 324

  Fly   319 LKDAKMDKSQIHDIVLVGGSTRIPKVQNLLQNFFGGKTLNLSINPDEAVAYGAAIQAAILSGDKS 383
            |..:|:.|..|:.:.:|||:||||.|:..:..|| ||.|:.::|.||||..|.|:|.||||  .:
  Rat   325 LDQSKLKKEDIYAVEIVGGATRIPAVKEKISKFF-GKELSTTLNADEAVTRGCALQCAILS--PA 386

  Fly   384 SEIKDVLLVDVAPLSLGIE-----TAGGVMTKLIERNSRIPCKQSKTFTTYADNQPAVTIQVFEG 443
            .::::..:.||.|..:.:.     ..|....::..:|...|.  ||..|.|. .:|......:..
  Rat   387 FKVREFSITDVVPYPISLRWNSPAEEGSSDCEVFPKNHAAPF--SKVLTFYR-KEPFTLEAYYSS 448

  Fly   444 ERALTKDNNVLGTFDLTGVPPAPRG-VPKIDVTFDLDANGILNVT-------------------- 487
            .:.|...:..:..|.:..|.|...| ..|:.|...::.:||.:|:
  Rat   449 PQDLPYPDPAIAQFSVQKVTPQSDGSSSKVKVKVRVNVHGIFSVSSAALVEVHKSEESEEPMETD 513

  Fly   488 --AKEQ-----------------------------------GTGN--------AKNITIK----- 502
              |||:                                   |:.:        ||...:|
  Rat   514 QNAKEEEKMQVDQEEPHTEEQQPQTPAENKAESEEMETSQAGSKDKKMDQPPQAKKAKVKTSTVD 578

  Fly   503 --------------------NDKGRLSQAD--------------------IDRMLSEAEKYAEED 527
                                .::|::...|                    .|::..|.||:..||
  Rat   579 LPIESQLLWQLDREMLGLYTENEGKMIMQDKLEKERNDAKNAVEEYVYEMRDKLSGEYEKFVSED 643

  Fly   528 ERHR-----------------------------------QRIAAR---------------NQLET 542
            :|:.                                   |.|..|               .|::.
  Rat   644 DRNNFTLKLEDTENWLYEDGEDQPKQVYVDKLAELRTLGQPIKTRFQESEERPKLFEELGKQIQQ 708

  Fly   543 YLFGVK--EAAENGGDRISAADKSSIVERCSEAMKWLDS--------NTTAE----KEEYEYKLK 593
            |:..:.  :..|:..:.:.|||.:.:.:..:|||:|::|        :.||:    .:|.|.|:|
  Rat   709 YMKVISSFKNKEDQYEHLDAADMTKVEKSTNEAMEWMNSKLNLQNKQSLTADPVVKTKEIEAKIK 773

  Fly   594 ELEQFCSPIMTKMHKGGGDGQQAPNFGQQAGGYKG 628
            ||...||||::|........::.|...:|.|...|
  Rat   774 ELTNICSPIISKPKPKVEPPKEEPKHAEQNGPVDG 808

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp68	NP_524474.1	PTZ00009	2..635	CDD:240227	220/814 (27%)
Hspa4	NP_705893.1	ASKHA_NBD_HSP70_HSPA4	2..382	CDD:466843	148/381 (39%)
		PTZ00121	<499..743	CDD:173412	27/243 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	500..575		7/74 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	781..840		7/28 (25%)