Protein Alignment Hsp68 and HSPA12A

DIOPT Version :10

• Sequence 1: NP_524474.1
• Gene: Hsp68 / 42852
• FlyBaseID: FBgn0001230
• Length: 635
• Species: Drosophila melanogaster
• Sequence 2: NP_001317093.1
• Gene: HSPA12A / 259217
• HGNCID: 19022
• Length: 692
• Species: Homo sapiens
• Alignment Length: 651
• Identity: 141/651 - (21%)
• Similarity: 227/651 - (34%)
• Gaps: 200/651 - (30%)

  Fly     4 IGIDLGTTYS-----------CVGVFQYGKVEIIANDQG--NRTTPSYVAFTDSERL--IGDAAK 53
            :.:|.|||.|           |:.|.:..:    ..|.|  |:.||:.:..|...:.  .|.||
Human    76 VAVDFGTTSSGYAYSFTKEPECIHVMRRWE----GGDPGVSNQKTPTTILLTPERKFHSFGYAA- 135

  Fly    54 NQVAMNPKNSVFDAKRLIGRRFDDSKIQEDIKHW----PFKV-INDNGKPKISVEFKGAN-KCFS 112
                               |.|.......:.|.|    .||: ::..|...:..:...|| |...
Human   136 -------------------RDFYHDLDPNEAKQWLYLEKFKMKLHTTGDLTMDTDLTAANGKKVK 181

  Fly   113 PEEISSMVLTKMKETAEAYL----GTTVKDA----VITVPAYFNDSQRQATKDAGAIAGI----- 164
            ..||.:..|...||.|...|    |:..:::    ||||||.:....:|..:.|...||:
Human   182 ALEIFAYALQYFKEQALKELSDQAGSEFENSDVRWVITVPAIWKQPAKQFMRQAAYQAGLASPEN 246

  Fly   165 -NVLRIINEPTAAAL--------------------AYG-------------------------LD 183
             ..|.|..||.||::                    .|.                         |.
Human   247 SEQLIIALEPEAASIYCRKLRLHQMIELSSKAAVNGYSGSDTVGAGFTQAKEHIRRNRQSRTFLV 311

  Fly   184 KNLKGE--------RNVLIFDLGGGTFDVSI--LTIDEGSLFEVRSTAGDTH--LGGE-DFDNRL 235
            :|:.||        ...::.|.||||.|:::  :.:.||.|.|:....|..:  ||.: :|:..|
Human   312 ENVIGEIWSELEEGDKYVVVDSGGGTVDLTVHQIRLPEGHLKELYKATGGPYGSLGVDYEFEKLL 376

  Fly   236 VNHFAEEFKRKYKKDLRSNPRALRRLRTAAERAKRTLSSSTEASLEIDALYEGHDFYSKVSRARF 300
            ...|.|:|..::|   ...|.|...|..|.|..||..:......|.|...:...|:|.|......
Human   377 YKIFGEDFIEQFK---IKRPAAWVDLMIAFESRKRAAAPDRTNPLNITLPFSFIDYYKKFRGHSV 438

  Fly   301 E-----------------------ELCGDLFRNTLEPVEKALKD--AKMDKSQIHDIVLVGGSTR 340
            |                       :....||:.|::.:.:.|:|  .|.:.|.:..:.||||...
Human   439 EHALRKSNVDFVKWSSQGMLRMSPDAMNALFKPTIDSIIEHLRDLFQKPEVSTVKFLFLVGGFAE 503

  Fly   341 IPKVQNLLQNFFGGKTLNLSINPDEAVAYGAAIQAAILSGDKSSEIKDVLLVDVAPLSLGIETAG 405
            .|.:|..:|..||.: ..:.|..|..:   ..::.|:|.|...:.||    |..:||:.|:
Human   504 APLLQQAVQAAFGDQ-CRIIIPQDVGL---TILKGAVLFGLDPAVIK----VRRSPLTYGV---- 556

  Fly   406 GVMTKLIER--------------------NSRIPCKQS--------KTFTTYADNQPAVTIQVFE 442
            ||:.:.:|.                    :..|...||        :::|....:|..:.|.::.
Human   557 GVLNRYVEGKHPPEKLLVKDGTRWCTDVFDKFISADQSVALGELVKRSYTPAKPSQLVIVINIYS 621

  Fly   443 GER---ALTKDNNV--LGT--FDLTGVP----PAPRGVPKIDVTF---DLDANGILNVTAKEQGT 493
            .|.   :...|..|  .||  .||||..    ||.|.:..: :.|   ::.|..|...|:|....
Human   622 SEHDNVSFITDPGVKKCGTLRLDLTGTSGTAVPARREIQTL-MQFGDTEIKATAIDIATSKSVKV 685

  Fly   494 G 494
            |
Human   686 G 686

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp68	NP_524474.1	PTZ00009	2..635	CDD:240227	141/651 (22%)
HSPA12A	NP_001317093.1	ASKHA_NBD_HSP70_HSPA12A	74..540	CDD:466841	107/494 (22%)