DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp68 and ssc1

DIOPT Version :9

Sequence 1:	NP_524474.1	Gene:	Hsp68 / 42852	FlyBaseID:	FBgn0001230	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_593459.1	Gene:	ssc1 / 2543026	PomBaseID:	SPAC664.11	Length:	674	Species:	Schizosaccharomyces pombe

Alignment Length:	632	Identity:	295/632 - (46%)
Similarity:	422/632 - (66%)	Gaps:	37/632 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PAIGIDLGTTYSCVGVFQYGKVEIIANDQGNRTTPSYVAFT-DSERLIGDAAKNQVAMNPKNSVF 65
            |.||||||||.||:.:.:....::|||.:|.|||||.|||| |.|||:|.:||.|..:||:|:.|
pombe    51 PVIGIDLGTTTSCLAIMEGQTPKVIANAEGTRTTPSVVAFTKDGERLVGVSAKRQAVINPENTFF 115

  Fly    66 DAKRLIGRRFDDSKIQEDIKHWPFKVI-NDNGKPKISVEFKGANKCFSPEEISSMVLTKMKETAE 129
            ..||||||||.:.::|.|||..|:|:: :.||...:  |.:|  |.:||.:|...:|:||:|||.
pombe   116 ATKRLIGRRFKEPEVQRDIKEVPYKIVEHSNGDAWL--EARG--KTYSPSQIGGFILSKMRETAS 176

  Fly   130 AYLGTTVKDAVITVPAYFNDSQRQATKDAGAIAGINVLRIINEPTAAALAYGLDKNLKGERNVLI 194
            .|||..||:||:|||||||||||||||.||||||:||||::||||||||||||||  |.:..|.:
pombe   177 TYLGKDVKNAVVTVPAYFNDSQRQATKAAGAIAGLNVLRVVNEPTAAALAYGLDK--KNDAIVAV 239

  Fly   195 FDLGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVNHFAEEFKRKYKKDLRSNPRALR 259
            |||||||||:|||.::.| :||||||.|||||||||||..||.|..|.||:....||..:..|::
pombe   240 FDLGGGTFDISILELNNG-VFEVRSTNGDTHLGGEDFDVALVRHIVETFKKNEGLDLSKDRLAVQ 303

  Fly   260 RLRTAAERAKRTLSSSTEASLEI-----DALYEGHDFYSKVSRARFEELCGDLFRNTLEPVEKAL 319
            |:|.|||:||..|||.::..:.:     ||....| ...::|||:||:|...|.|.|::|.::||
pombe   304 RIREAAEKAKCELSSLSKTDISLPFITADATGPKH-INMEISRAQFEKLVDPLVRRTIDPCKRAL 367

  Fly   320 KDAKMDKSQIHDIVLVGGSTRIPKVQNLLQNFFGGKTLNLSINPDEAVAYGAAIQAAILSGDKSS 384
            |||.:..|:|::::||||.||:|:|...:::.|..:... |:|||||||.|||||..:|||
pombe   368 KDANLQTSEINEVILVGGMTRMPRVVETVKSIFKREPAK-SVNPDEAVAIGAAIQGGVLSG---- 427

  Fly   385 EIKDVLLVDVAPLSLGIETAGGVMTKLIERNSRIPCKQSKTFTTYADNQPAVTIQVFEGERALTK 449
            .:||::|:||.||||||||.|||.|:||.||:.||.::|:.|:|.||.|.||.|:||:|||.|.:
pombe   428 HVKDLVLLDVTPLSLGIETLGGVFTRLINRNTTIPTRKSQVFSTAADGQTAVEIRVFQGERELVR 492

  Fly   450 DNNVLGTFDLTGVPPAPRGVPKIDVTFDLDANGILNVTAKEQGTGNAKNITIKNDKGRLSQADID 514
            ||.::|.|.|||:.|||:|.|:|:|:||:||:||:||:|:::.|....:||:....| |:.::|:
pombe   493 DNKLIGNFQLTGIAPAPKGQPQIEVSFDVDADGIINVSARDKATNKDSSITVAGSSG-LTDSEIE 556

  Fly   515 RMLSEAEKYAEEDERHRQRIAARNQLETYLFGVKEAAENGGDRISAADKSSIVERCSEAMKWLDS 579
            .|:::||||...|...::.|...|:.|:....::...:...|::   |:.::.:..|   |..|.
pombe   557 AMVADAEKYRASDMARKEAIENGNRAESVCTDIESNLDIHKDKL---DQQAVEDLRS---KITDL 615

  Fly   580 NTTAEK----------EEYEYKLKELEQFCSPIMTKMHKGGGDGQQA 616
            ..|..|          |:.:.|:.|::|....:...::|....|.::
pombe   616 RETVAKVNAGDEGITSEDMKKKIDEIQQLSLKVFESVYKNQNQGNES 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp68	NP_524474.1	PTZ00009	2..635	CDD:240227	295/632 (47%)
Hsp68	NP_524474.1	HSPA1-2_6-8-like_NBD	3..379	CDD:212675	202/382 (53%)
ssc1	NP_593459.1	dnaK	49..671	CDD:234715	295/632 (47%)
ssc1	NP_593459.1	HSPA9-like_NBD	49..425	CDD:212683	203/382 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810