DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp68 and bip1

DIOPT Version :9

Sequence 1:	NP_524474.1	Gene:	Hsp68 / 42852	FlyBaseID:	FBgn0001230	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_593245.1	Gene:	bip1 / 2541815	PomBaseID:	SPAC22A12.15c	Length:	663	Species:	Schizosaccharomyces pombe

Alignment Length:	618	Identity:	351/618 - (56%)
Similarity:	474/618 - (76%)	Gaps:	11/618 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IGIDLGTTYSCVGVFQYGKVEIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPKNSVFDAK 68
            ||||||||||||.|.:.|:|||||||||||.||||||||:.|||:|:|||||...||:|::||.|
pombe    38 IGIDLGTTYSCVAVMKNGRVEIIANDQGNRITPSYVAFTEDERLVGEAAKNQAPSNPENTIFDIK 102

  Fly    69 RLIGRRFDDSKIQEDIKHWPFKVINDNGKPKISVEFKGANKCFSPEEISSMVLTKMKETAEAYLG 133
            |||||:||:..:.:|||.:||.::||..:|.:.|...|..|.|:|||||:|:|:|||:|||||||
pombe   103 RLIGRKFDEKTMAKDIKSFPFHIVNDKNRPLVEVNVGGKKKKFTPEEISAMILSKMKQTAEAYLG 167

  Fly   134 TTVKDAVITVPAYFNDSQRQATKDAGAIAGINVLRIINEPTAAALAYGLDKNLKGERNVLIFDLG 198
            ..|..||:||||||||:|||||||||.|||:||:||:|||||||:||||||. ..|::::::|||
pombe   168 KPVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVIRIVNEPTAAAIAYGLDKT-DTEKHIVVYDLG 231

  Fly   199 GGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVNHFAEEFKRKYKKDLRSNPRALRRLRT 263
            |||||||:|:||.| :|||.:|:|||||||||||||::|:.|..:.||...|:..:.:|:.:|:.
pombe   232 GGTFDVSLLSIDNG-VFEVLATSGDTHLGGEDFDNRVINYLARTYNRKNNVDVTKDLKAMGKLKR 295

  Fly   264 AAERAKRTLSSSTEASLEIDALYEGHDFYSKVSRARFEELCGDLFRNTLEPVEKALKDAKMDKSQ 328
            ..|:|||||||.....:||::.:.|.||...:|||:|||:..|||:.||:|||:.|||:.:.||:
pombe   296 EVEKAKRTLSSQKSVRIEIESFFNGQDFSETLSRAKFEEINMDLFKKTLKPVEQVLKDSNLKKSE 360

  Fly   329 IHDIVLVGGSTRIPKVQNLLQNFFGGKTLNLSINPDEAVAYGAAIQAAILSGDKSSEIKDVLLVD 393
            |.|||||||||||||||.||::|| ||..:..||||||||||||:||.:|||::.|:  :::|:|
pombe   361 IDDIVLVGGSTRIPKVQELLESFF-GKKASKGINPDEAVAYGAAVQAGVLSGEEGSD--NIVLLD 422

  Fly   394 VAPLSLGIETAGGVMTKLIERNSRIPCKQSKTFTTYADNQPAVTIQVFEGERALTKDNNVLGTFD 458
            |.||:|||||.||||||||.||:.||.::|:.|:|..|||..|.|||:||||.||||||:||.||
pombe   423 VIPLTLGIETTGGVMTKLIGRNTPIPTRKSQIFSTAVDNQNTVLIQVYEGERTLTKDNNLLGKFD 487

  Fly   459 LTGVPPAPRGVPKIDVTFDLDANGILNVTAKEQ-GTGNAKNITIKNDKGRLSQADIDRMLSEAEK 522
            |.|:||||||||:|:|||::||||:|.|:|.:: |.|..:.:.|||||||||:.||:||:.|||:
pombe   488 LRGIPPAPRGVPQIEVTFEVDANGVLTVSAVDKSGKGKPEKLVIKNDKGRLSEEDIERMVKEAEE 552

  Fly   523 YAEEDERHRQRIAARNQLETYLFGVK---EAAENGGDRISAADKSSIVERCSEAMKWLD-SNTTA 583
            :||||:..::||.|||.||.|.:.:|   :..|..|.::...||.::::...:..:||: ....|
pombe   553 FAEEDKILKERIEARNTLENYAYSLKGQFDDDEQLGGKVDPEDKQAVLDAVEDVAEWLEIHGEDA 617

  Fly   584 EKEEYEYKLKELEQFCSPIMTKMH-KGGGDGQQ 615
            .|||:|.:.::|:....||..|:: :|.||..:
pombe   618 SKEEFEDQRQKLDAVVHPITQKLYSEGAGDADE 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp68	NP_524474.1	PTZ00009	2..635	CDD:240227	351/618 (57%)
Hsp68	NP_524474.1	HSPA1-2_6-8-like_NBD	3..379	CDD:212675	231/374 (62%)
bip1	NP_593245.1	HSPA5-like_NBD	35..407	CDD:212681	230/371 (62%)
bip1	NP_593245.1	HSP70	37..641	CDD:278441	348/607 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53894
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720