DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hsp68 and Hspa8

DIOPT Version :9

Sequence 1:NP_524474.1 Gene:Hsp68 / 42852 FlyBaseID:FBgn0001230 Length:635 Species:Drosophila melanogaster
Sequence 2:NP_077327.1 Gene:Hspa8 / 24468 RGDID:621725 Length:646 Species:Rattus norvegicus


Alignment Length:646 Identity:462/646 - (71%)
Similarity:548/646 - (84%) Gaps:16/646 - (2%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 PAIGIDLGTTYSCVGVFQYGKVEIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPKNSVFD 66
            ||:|||||||||||||||:|||||||||||||||||||||||:||||||||||||||||.|:|||
  Rat     5 PAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTVFD 69

  Fly    67 AKRLIGRRFDDSKIQEDIKHWPFKVINDNGKPKISVEFKGANKCFSPEEISSMVLTKMKETAEAY 131
            |||||||||||:.:|.|:|||||.|:||.|:||:.||:||..|.|.|||:||||||||||.||||
  Rat    70 AKRLIGRRFDDAVVQSDMKHWPFMVVNDAGRPKVQVEYKGETKSFYPEEVSSMVLTKMKEIAEAY 134

  Fly   132 LGTTVKDAVITVPAYFNDSQRQATKDAGAIAGINVLRIINEPTAAALAYGLDKNLKGERNVLIFD 196
            ||.||.:||:||||||||||||||||||.|||:|||||||||||||:||||||.:..||||||||
  Rat   135 LGKTVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKVGAERNVLIFD 199

  Fly   197 LGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVNHFAEEFKRKYKKDLRSNPRALRRL 261
            |||||||||||||::| :|||:||||||||||||||||:||||..|||||:|||:..|.||:|||
  Rat   200 LGGGTFDVSILTIEDG-IFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDISENKRAVRRL 263

  Fly   262 RTAAERAKRTLSSSTEASLEIDALYEGHDFYSKVSRARFEELCGDLFRNTLEPVEKALKDAKMDK 326
            |||.|||||||||||:||:|||:||||.|||:.::|||||||..||||.||:||||||:|||:||
  Rat   264 RTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAKLDK 328

  Fly   327 SQIHDIVLVGGSTRIPKVQNLLQNFFGGKTLNLSINPDEAVAYGAAIQAAILSGDKSSEIKDVLL 391
            |||||||||||||||||:|.|||:||.||.||.|||||||||||||:||||||||||..::|:||
  Rat   329 SQIHDIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQDLLL 393

  Fly   392 VDVAPLSLGIETAGGVMTKLIERNSRIPCKQSKTFTTYADNQPAVTIQVFEGERALTKDNNVLGT 456
            :||.||||||||||||||.||:||:.||.||::|||||:||||.|.|||:|||||:|||||:||.
  Rat   394 LDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLGK 458

  Fly   457 FDLTGVPPAPRGVPKIDVTFDLDANGILNVTAKEQGTGNAKNITIKNDKGRLSQADIDRMLSEAE 521
            |:|||:||||||||:|:||||:||||||||:|.::.||....|||.|||||||:.||:||:.|||
  Rat   459 FELTGIPPAPRGVPQIEVTFDIDANGILNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQEAE 523

  Fly   522 KYAEEDERHRQRIAARNQLETYLFGVKEAAENG--GDRISAADKSSIVERCSEAMKWLDSNTTAE 584
            ||..|||:.|.:::::|.||:|.|.:|...|:.  ..:|:..||..|:::|:|.:.|||.|.|||
  Rat   524 KYKAEDEKQRDKVSSKNSLESYAFNMKATVEDEKLQGKINDEDKQKILDKCNEIISWLDKNQTAE 588

  Fly   585 KEEYEYKLKELEQFCSPIMTKMHK----------GGGDGQQAPNFGQQAGGYKGPTVEEVD 635
            |||:|::.||||:.|:||:||:::          ||..|..||..|   |...|||:||||
  Rat   589 KEEFEHQQKELEKVCNPIITKLYQSAGGMPGGMPGGFPGGGAPPSG---GASSGPTIEEVD 646

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hsp68NP_524474.1 PTZ00009 2..635 CDD:240227 460/644 (71%)
HSPA1-2_6-8-like_NBD 3..379 CDD:212675 305/375 (81%)
Hspa8NP_077327.1 PTZ00009 1..613 CDD:240227 448/608 (74%)
Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142 2..386 311/381 (82%)
Interaction with BAG1. /evidence=ECO:0000250 186..377 151/191 (79%)
Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142 394..509 83/114 (73%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 614..646 12/34 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0443
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53894
OrthoDB 1 1.010 - - D180577at33208
OrthoFinder 1 1.000 - - FOG0000049
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100083
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
76.730

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