DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hsp68 and HSPA4L

DIOPT Version :9

Sequence 1:NP_524474.1 Gene:Hsp68 / 42852 FlyBaseID:FBgn0001230 Length:635 Species:Drosophila melanogaster
Sequence 2:NP_001304310.1 Gene:HSPA4L / 22824 HGNCID:17041 Length:870 Species:Homo sapiens


Alignment Length:830 Identity:222/830 - (26%)
Similarity:358/830 - (43%) Gaps:233/830 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MPAIGIDLGTTYSCVGVFQYGKVEIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPKNSVF 65
            |..:|||||.....:.|.:.|.:|.|||:..:|.||:.::.....|.||:|||:|:..|.:|::.
Human    32 MSVVGIDLGFLNCYIAVARSGGIETIANEYSDRCTPACISLGSRTRAIGNAAKSQIVTNVRNTIH 96

  Fly    66 DAKRLIGRRFDDSKIQEDIKHWPFKVIN-DNGKPKISVEFKGANKCFSPEEISSMVLTKMKETAE 129
            ..|:|.||.|||..:|.:....|:::.. .||...:.|.:....:.|:.|:::.|:|.|:|||:|
Human    97 GFKKLHGRSFDDPIVQTERIRLPYELQKMPNGSAGVKVRYLEEERPFAIEQVTGMLLAKLKETSE 161

  Fly   130 AYLGTTVKDAVITVPAYFNDSQRQATKDAGAIAGINVLRIINEPTAAALAYGLDKN-----LKGE 189
            ..|...|.|.||::|::|.|::|::...|..:||:|.||::||.||.|||||:.|.     .:..
Human   162 NALKKPVADCVISIPSFFTDAERRSVMAAAQVAGLNCLRLMNETTAVALAYGIYKQDLPPLDEKP 226

  Fly   190 RNVLIFDLGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVNHFAEEFKRKYKKDLRSN 254
            |||:..|:|...:.|.:...::|.| :|.:|..|.:|||.:||..||::|.:|||.|||.:::.|
Human   227 RNVVFIDMGHSAYQVLVCAFNKGKL-KVLATTFDPYLGGRNFDEALVDYFCDEFKTKYKINVKEN 290

  Fly   255 PRALRRLRTAAERAKRTLS-SSTEASLEIDALYEGHDFYSKVSRARFEELCGDLFRNTLEPVEKA 318
            .|||.||....|:.|:.:| ::::..|.|:......|..||::||:||:||..|......|::..
Human   291 SRALLRLYQECEKLKKLMSANASDLPLNIECFMNDLDVSSKMNRAQFEQLCASLLARVEPPLKAV 355

  Fly   319 LKDAKMDKSQIHDIVLVGGSTRIPKVQNLLQNFFGGKTLNLSINPDEAVAYGAAIQAAILSGDKS 383
            ::.|.:.:..|..|.:|||:||||.|:..:..|| .|.::.::|.|||||.|.|:|.||||  .:
Human   356 MEQANLQREDISSIEIVGGATRIPAVKEQITKFF-LKDISTTLNADEAVARGCALQCAILS--PA 417

  Fly   384 SEIKDVLLVDVAPLSL------GIETAGGVMTKLIERNSRIPCKQSKTFTTYADNQPAVTIQVFE 442
            .::::..:.|:.|.|:      ..|...|......:.:   |...||.. |:...:|      ||
Human   418 FKVREFSITDLVPYSITLRWKTSFEDGSGECEVFCKNH---PAPFSKVI-TFHKKEP------FE 472

  Fly   443 GERALTKDNNV------LGTFDLTGVPPAPRG-VPKIDVTFDLDANGILNVTA------------ 488
            .|...|..:.|      :|:|.:..|.|...| ..|:.|...::.:||.:|.:            
Human   473 LEAFYTNLHEVPYPDARIGSFTIQNVFPQSDGDSSKVKVKVRVNIHGIFSVASASVIEKQNLEGD 537

  Fly   489 --------------------------KEQG----------------TGNAK------------NI 499
                                      :|:|                || ||            |.
Human   538 HSDAPMETETSFKNENKDNMDKMQVDQEEGHQKCHAEHTPEEEIDHTG-AKTKSAVSDKQDRLNQ 601

  Fly   500 TIKNDKGRLSQADID------RMLSE--AEKYAE-------EDERHRQRIAARNQLETYLFG--- 546
            |:|  ||::...|:.      |.|.:  ...|.|       :|:..::|..|:|.:|.|::.   
Human   602 TLK--KGKVKSIDLPIQSSLCRQLGQDLLNSYIENEGKMIMQDKLEKERNDAKNAVEEYVYDFRD 664

  Fly   547 ----------------------------------------------------------------- 546
                                                                             
Human   665 RLGTVYEKFITPEDLSKLSAVLEDTENWLYEDGEDQPKQVYVDKLQELKKYGQPIQMKYMEHEER 729

  Fly   547 ----------------VKEAAENGGDRISAADKSSI--VERC-SEAMKWLDSNTTAEKE------ 586
                            |.||..|..:|....|.:.:  ||:| |:||.||:|...|:.:      
Human   730 PKALNDLGKKIQLVMKVIEAYRNKDERYDHLDPTEMEKVEKCISDAMSWLNSKMNAQNKLSLTQD 794

  Fly   587 ------EYEYKLKELEQFCSPIMTK----------------MHKGGGDGQ 614
                  |...|.|||:.||:||:.|                .|.|..|||
Human   795 PVVKVSEIVAKSKELDNFCNPIIYKPKPKAEVPEDKPKANSEHNGPMDGQ 844

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hsp68NP_524474.1 PTZ00009 2..635 CDD:240227 221/829 (27%)
HSPA1-2_6-8-like_NBD 3..379 CDD:212675 141/382 (37%)
HSPA4LNP_001304310.1 HSPA4L_NBD 33..415 CDD:212688 141/383 (37%)
HSP70 34..725 CDD:278441 190/707 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0443
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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