DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp68 and Hspa1a

DIOPT Version :9

Sequence 1:	NP_524474.1	Gene:	Hsp68 / 42852	FlyBaseID:	FBgn0001230	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_034609.2	Gene:	Hspa1a / 193740	MGIID:	96244	Length:	641	Species:	Mus musculus

Alignment Length:	641	Identity:	464/641 - (72%)
Similarity:	553/641 - (86%)	Gaps:	13/641 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 AIGIDLGTTYSCVGVFQYGKVEIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPKNSVFDA 67
            |||||||||||||||||:|||||||||||||||||||||||:|||||||||||||:||:|:||||
Mouse     6 AIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDA 70

  Fly    68 KRLIGRRFDDSKIQEDIKHWPFKVINDNGKPKISVEFKGANKCFSPEEISSMVLTKMKETAEAYL 132
            ||||||:|.|:.:|.|:|||||:|:||..|||:.|.:||.::.|.||||||||||||||.|||||
Mouse    71 KRLIGRKFGDAVVQSDMKHWPFQVVNDGDKPKVQVNYKGESRSFFPEEISSMVLTKMKEIAEAYL 135

  Fly   133 GTTVKDAVITVPAYFNDSQRQATKDAGAIAGINVLRIINEPTAAALAYGLDKNLKGERNVLIFDL 197
            |..|.:|||||||||||||||||||||.|||:|||||||||||||:|||||:..|||||||||||
Mouse   136 GHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDL 200

  Fly   198 GGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVNHFAEEFKRKYKKDLRSNPRALRRLR 262
            |||||||||||||:| :|||::|||||||||||||||||:||.||||||:|||:..|.||:||||
Mouse   201 GGGTFDVSILTIDDG-IFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLR 264

  Fly   263 TAAERAKRTLSSSTEASLEIDALYEGHDFYSKVSRARFEELCGDLFRNTLEPVEKALKDAKMDKS 327
            ||.|||||||||||:||||||:|:||.|||:.::||||||||.||||.|||||||||:||||||:
Mouse   265 TACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKMDKA 329

  Fly   328 QIHDIVLVGGSTRIPKVQNLLQNFFGGKTLNLSINPDEAVAYGAAIQAAILSGDKSSEIKDVLLV 392
            ||||:|||||||||||||.|||:||.|:.||.|||||||||||||:|||||.||||..::|:||:
Mouse   330 QIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLL 394

  Fly   393 DVAPLSLGIETAGGVMTKLIERNSRIPCKQSKTFTTYADNQPAVTIQVFEGERALTKDNNVLGTF 457
            ||||||||:||||||||.||:|||.||.||::|||||:||||.|.|||:|||||:|:|||:||.|
Mouse   395 DVAPLSLGLETAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRF 459

  Fly   458 DLTGVPPAPRGVPKIDVTFDLDANGILNVTAKEQGTGNAKNITIKNDKGRLSQADIDRMLSEAEK 522
            :|:|:||||||||:|:||||:||||||||||.::.||.|..|||.|||||||:.:|:||:.|||:
Mouse   460 ELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAER 524

  Fly   523 YAEEDERHRQRIAARNQLETYLFGVKEAAENGG--DRISAADKSSIVERCSEAMKWLDSNTTAEK 585
            |..|||..|.|:||:|.||:|.|.:|.|.|:.|  .::|.|||..::::|.|.:.||||||.|:|
Mouse   525 YKAEDEVQRDRVAAKNALESYAFNMKSAVEDEGLKGKLSEADKKKVLDKCQEVISWLDSNTLADK 589

  Fly   586 EEYEYKLKELEQFCSPIMTKMHKG------GGDGQQAPNFGQQAGGYKGPTVEEVD 635
            ||:.:|.:|||:.||||::.:::|      ||.|.|||   :.|.| .|||:||||
Mouse   590 EEFVHKREELERVCSPIISGLYQGAGAPGAGGFGAQAP---KGASG-SGPTIEEVD 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp68	NP_524474.1	PTZ00009	2..635	CDD:240227	462/639 (72%)
Hsp68	NP_524474.1	HSPA1-2_6-8-like_NBD	3..379	CDD:212675	305/375 (81%)
Hspa1a	NP_034609.2	PTZ00009	1..641	CDD:240227	462/639 (72%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250\|UniProtKB:P11142	2..386		309/380 (81%)
		HSPA1-2_6-8-like_NBD	6..381	CDD:212675	305/375 (81%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250\|UniProtKB:P11142	394..509		84/114 (74%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	618..641		13/26 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H74294
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53894
OrthoDB	1	1.010	-	-		D180577at33208
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	1	1.100	-	-	O	PTHR19375
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.830