DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp68 and Hyou1

DIOPT Version :9

Sequence 1:	NP_524474.1	Gene:	Hsp68 / 42852	FlyBaseID:	FBgn0001230	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_001029200.1	Gene:	Hyou1 / 192235	RGDID:	621146	Length:	998	Species:	Rattus norvegicus

Alignment Length:	693	Identity:	208/693 - (30%)
Similarity:	333/693 - (48%)	Gaps:	103/693 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPAIGIDLGTTYSCVGVFQYG-KVEIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPKNSV 64
            :..:.:|||:....|.:.:.| .:||:.|.:..|.||..|...::||.:||:|......|||.::
  Rat    33 LAVMSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPVTVTLKENERFLGDSAAGMAIKNPKATL 97

  Fly    65 FDAKRLIGRRFDDSKIQEDIKHWPFKVINDNGKPKISVEFKGANKC-FSPEEISSMVLTKMKETA 128
            ...:.|:|::.|:..:......:|...:|.:.: :.:|.|:.:.:. |||||:..|||...:..|
  Rat    98 RYFQHLLGKQADNPHVALYRSRFPEHELNVDPQ-RQTVRFQISPQLQFSPEEVLGMVLNYSRSLA 161

  Fly   129 EAYLGTTVKDAVITVPAYFNDSQRQATKDAGAIAGINVLRIINEPTAAALAYGL----DKNLKGE 189
            |.:....:|||||||||:||.::|:|...|..:||:.||::||:.||.||:||:    |.|...:
  Rat   162 EDFAEQPIKDAVITVPAFFNQAERRAVLQAARMAGLKVLQLINDNTATALSYGVFRRKDINSTAQ 226

  Fly   190 RNVLIFDLGGGTFDVSILTI------DEGS--LFEVRSTAGDTHLGGEDFDNRLVNHFAEEFKRK 246
             |::.:|:|.|:...:|:|.      :.|:  ..::|....|..|||.:.:.||..|.|:.|..:
  Rat   227 -NIMFYDMGSGSTVCTIVTYQTVKTKEAGTQPQLQIRGVGFDRTLGGLEMELRLREHLAKLFNEQ 290

  Fly   247 YK----KDLRSNPRALRRLRTAAERAKRTLSSSTEASLEIDALYEGHDFYSKVSRARFEELCGDL 307
            .|    ||:|.||||:.:|...|.|.|..||::.:...:|:.|.:..||.:||:|..|||||.||
  Rat   291 RKGQKAKDVRENPRAMAKLLREANRLKTVLSANADHMAQIEGLMDDVDFKAKVTRVEFEELCADL 355

  Fly   308 FRNTLEPVEKALKDAKMDKSQIHDIVLVGGSTRIPKVQNLLQNFFGGKTLNLSINPDEAVAYGAA 372
            |.....||::||:.|:|...||..::||||:||:||||.:|....|.:.|..:||.|||.|.||.
  Rat   356 FDRVPGPVQQALQSAEMSLDQIEQVILVGGATRVPKVQEVLLKAVGKEELGKNINADEAAAMGAV 420

  Fly   373 IQAAILSGDKSSEIKDVLLVD--VAPL----SLGIETAGGVMTKLIERNSRI------PCKQSK- 424
            .|||.||  |:.::|..::.|  :.|:    :..:|...|:  :.::.|.|:      |..|.|
  Rat   421 YQAAALS--KAFKVKPFVVRDAVIYPILVEFTREVEEEPGL--RSLKHNKRVLFSRMGPYPQRKV 481

  Fly   425 -TFTTYADNQPAVTIQVFEGERAL--TKDNNVLGTFDLT-----GVPPAPRGVPK-----IDVTF 476
             ||..|:.:   ....:..|:...  .:|..|.|:.:||     ||..:.:..|.     |...|
  Rat   482 ITFNRYSHD---FNFHINYGDLGFLGPEDLRVFGSQNLTTVKLKGVGESFKKYPDYESKGIKAHF 543

  Fly   477 DLDANGILNVTAKEQGTGNAKNITIKNDKGRLSQADIDRMLSEAEKYAEEDERHRQRIAARNQLE 541
            :||.:|:|:                           :||:.|..|...|:.......:.......
  Rat   544 NLDESGVLS---------------------------LDRVESVFETLVEDSPEEESTLTKLGNTI 581

  Fly   542 TYLFG---VKEAAENGGDRISAADKSSIVERCSEAMKWLDSNTTAEKEEYEYKLKELEQFCSPIM 603
            :.|||   ..:|.|||.|.:...::|.     :|..|...:.....|||.|..:::..|  .|..
  Rat   582 SSLFGGGTSSDAKENGTDAVQEEEESP-----AEGSKDEPAEQGELKEEAEAPMEDTSQ--PPPS 639

  Fly   604 -----------TKMHKGGGDGQQA--PNFGQQAGGYKGPTVEE 633
                       |...|..||..:|  ||...|||....|...|
  Rat   640 EPKGDAAREGETPDEKESGDKSEAQKPNEKGQAGPEGVPPAPE 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp68	NP_524474.1	PTZ00009	2..635	CDD:240227	208/692 (30%)
Hsp68	NP_524474.1	HSPA1-2_6-8-like_NBD	3..379	CDD:212675	143/393 (36%)
Hyou1	NP_001029200.1	HSP70	35..700	CDD:278441	208/691 (30%)
		HYOU1-like_NBD	36..424	CDD:212672	141/389 (36%)
		RR_TM4-6	549..>706	CDD:283990	36/168 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	564..694		30/126 (24%)
		Prevents secretion from ER. /evidence=ECO:0000255	995..998
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810