Protein Alignment Hsp68 and Hspa9

DIOPT Version :10

• Sequence 1: NP_524474.1
• Gene: Hsp68 / 42852
• FlyBaseID: FBgn0001230
• Length: 635
• Species: Drosophila melanogaster
• Sequence 2: NP_034611.2
• Gene: Hspa9 / 15526
• MGIID: 96245
• Length: 679
• Species: Mus musculus
• Alignment Length: 629
• Identity: 310/629 - (49%)
• Similarity: 418/629 - (66%)
• Gaps: 31/629 - (4%)

  Fly     4 IGIDLGTTYSCVGVFQYGKVEIIANDQGNRTTPSYVAFT-DSERLIGDAAKNQVAMNPKNSVFDA 67
            :|||||||.|||.|.:..:.:::.|.:|.|||||.|||| |.|||:|..||.|...||.|:.:..
Mouse    56 VGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTFYAT 120

  Fly    68 KRLIGRRFDDSKIQEDIKHWPFKVIN-DNGKPKISVEFKGANKCFSPEEISSMVLTKMKETAEAY 131
            |||||||:||.::|:|.|:.|||::. .||...:...    .|.:||.:|.:.||.|||||||.|
Mouse   121 KRLIGRRYDDPEVQKDTKNVPFKIVRASNGDAWVEAH----GKLYSPSQIGAFVLMKMKETAENY 181

  Fly   132 LGTTVKDAVITVPAYFNDSQRQATKDAGAIAGINVLRIINEPTAAALAYGLDKNLKGERNVLIFD 196
            ||.|.|:|||||||||||||||||||||.|:|:||||:|||||||||||||||:  .::.:.::|
Mouse   182 LGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKS--EDKVIAVYD 244

  Fly   197 LGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVNHFAEEFKRKYKKDLRSNPRALRRL 261
            |||||||:|||.|.:| :|||:||.|||.|||||||..|:.|..:||||:...||..:..||:|:
Mouse   245 LGGGTFDISILEIQKG-VFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMALQRV 308

  Fly   262 RTAAERAKRTLSSSTEAS-----LEIDALYEGHDFYSKVSRARFEELCGDLFRNTLEPVEKALKD 321
            |.|||:||..||||.:..     |.:||....| ...|::||:||.:..||.:.|:.|.:||::|
Mouse   309 REAAEKAKCELSSSVQTDINLPYLTMDASGPKH-LNMKLTRAQFEGIVTDLIKRTIAPCQKAMQD 372

  Fly   322 AKMDKSQIHDIVLVGGSTRIPKVQNLLQNFFGGKTLNLSINPDEAVAYGAAIQAAILSGDKSSEI 386
            |::.||.|.:::||||.||:||||..:|:.| |:..:.::|||||||.|||||..:|:||    :
Mouse   373 AEVSKSDIGEVILVGGMTRMPKVQQTVQDLF-GRAPSKAVNPDEAVAIGAAIQGGVLAGD----V 432

  Fly   387 KDVLLVDVAPLSLGIETAGGVMTKLIERNSRIPCKQSKTFTTYADNQPAVTIQVFEGERALTKDN 451
            .||||:||.||||||||.|||.||||.||:.||.|:|:.|:|.||.|..|.|:|.:|||.:..||
Mouse   433 TDVLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAGDN 497

  Fly   452 NVLGTFDLTGVPPAPRGVPKIDVTFDLDANGILNVTAKEQGTGNAKNITIKNDKGRLSQADIDRM 516
            .:||.|.|.|:||||||||:|:||||:|||||::|:||::|||..:.|.|:: .|.||:.||:.|
Mouse   498 KLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVIQS-SGGLSKDDIENM 561

  Fly   517 LSEAEKYAEEDERHRQRIAARNQLETYLFGVKEAAENGGDRISAADKSSIVERCSEAMKWLDSNT 581
            :..||||||||.|.::|:.|.|..|..:...:...|...|::.|.:.:.:.|..|:....|....
Mouse   562 VKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPADECNKLKEEISKMRALLAGKD 626

  Fly   582 TAEKEEYEYKLKELEQFCSPIMTKMHK----------GGGDGQQ 615
            :...|........|:|....:....:|          ..|.|:|
Mouse   627 SETGENIRQAASSLQQASLKLFEMAYKKMASEREGSGSSGTGEQ 670

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp68	NP_524474.1	PTZ00009	2..635	CDD:240227	310/629 (49%)
Hspa9	NP_034611.2	Interaction with NFS1. /evidence=ECO:0000250|UniProtKB:P38646	1..432		207/388 (53%)
		dnaK	52..673	CDD:234715	310/629 (49%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P38646	63..431		199/376 (53%)
		Interaction with FXN and ISCU. /evidence=ECO:0000250|UniProtKB:P38646	432..679		103/240 (43%)
		Interdomain linker. /evidence=ECO:0000250|UniProtKB:P38646	432..441		5/8 (63%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P38646	442..679		97/230 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	656..679		3/15 (20%)