DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp68 and Hspa9

DIOPT Version :9

Sequence 1:	NP_524474.1	Gene:	Hsp68 / 42852	FlyBaseID:	FBgn0001230	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_034611.2	Gene:	Hspa9 / 15526	MGIID:	96245	Length:	679	Species:	Mus musculus

Alignment Length:	629	Identity:	310/629 - (49%)
Similarity:	418/629 - (66%)	Gaps:	31/629 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IGIDLGTTYSCVGVFQYGKVEIIANDQGNRTTPSYVAFT-DSERLIGDAAKNQVAMNPKNSVFDA 67
            :|||||||.|||.|.:..:.:::.|.:|.|||||.|||| |.|||:|..||.|...||.|:.:..
Mouse    56 VGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTFYAT 120

  Fly    68 KRLIGRRFDDSKIQEDIKHWPFKVIN-DNGKPKISVEFKGANKCFSPEEISSMVLTKMKETAEAY 131
            |||||||:||.::|:|.|:.|||::. .||...:...    .|.:||.:|.:.||.|||||||.|
Mouse   121 KRLIGRRYDDPEVQKDTKNVPFKIVRASNGDAWVEAH----GKLYSPSQIGAFVLMKMKETAENY 181

  Fly   132 LGTTVKDAVITVPAYFNDSQRQATKDAGAIAGINVLRIINEPTAAALAYGLDKNLKGERNVLIFD 196
            ||.|.|:|||||||||||||||||||||.|:|:||||:|||||||||||||||:  .::.:.::|
Mouse   182 LGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKS--EDKVIAVYD 244

  Fly   197 LGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVNHFAEEFKRKYKKDLRSNPRALRRL 261
            |||||||:|||.|.:| :|||:||.|||.|||||||..|:.|..:||||:...||..:..||:|:
Mouse   245 LGGGTFDISILEIQKG-VFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMALQRV 308

  Fly   262 RTAAERAKRTLSSSTEAS-----LEIDALYEGHDFYSKVSRARFEELCGDLFRNTLEPVEKALKD 321
            |.|||:||..||||.:..     |.:||....| ...|::||:||.:..||.:.|:.|.:||::|
Mouse   309 REAAEKAKCELSSSVQTDINLPYLTMDASGPKH-LNMKLTRAQFEGIVTDLIKRTIAPCQKAMQD 372

  Fly   322 AKMDKSQIHDIVLVGGSTRIPKVQNLLQNFFGGKTLNLSINPDEAVAYGAAIQAAILSGDKSSEI 386
            |::.||.|.:::||||.||:||||..:|:.| |:..:.::|||||||.|||||..:|:||    :
Mouse   373 AEVSKSDIGEVILVGGMTRMPKVQQTVQDLF-GRAPSKAVNPDEAVAIGAAIQGGVLAGD----V 432

  Fly   387 KDVLLVDVAPLSLGIETAGGVMTKLIERNSRIPCKQSKTFTTYADNQPAVTIQVFEGERALTKDN 451
            .||||:||.||||||||.|||.||||.||:.||.|:|:.|:|.||.|..|.|:|.:|||.:..||
Mouse   433 TDVLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAGDN 497

  Fly   452 NVLGTFDLTGVPPAPRGVPKIDVTFDLDANGILNVTAKEQGTGNAKNITIKNDKGRLSQADIDRM 516
            .:||.|.|.|:||||||||:|:||||:|||||::|:||::|||..:.|.|:: .|.||:.||:.|
Mouse   498 KLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVIQS-SGGLSKDDIENM 561

  Fly   517 LSEAEKYAEEDERHRQRIAARNQLETYLFGVKEAAENGGDRISAADKSSIVERCSEAMKWLDSNT 581
            :..||||||||.|.::|:.|.|..|..:...:...|...|::.|.:.:.:.|..|:....|....
Mouse   562 VKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPADECNKLKEEISKMRALLAGKD 626

  Fly   582 TAEKEEYEYKLKELEQFCSPIMTKMHK----------GGGDGQQ 615
            :...|........|:|....:....:|          ..|.|:|
Mouse   627 SETGENIRQAASSLQQASLKLFEMAYKKMASEREGSGSSGTGEQ 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp68	NP_524474.1	PTZ00009	2..635	CDD:240227	310/629 (49%)
Hsp68	NP_524474.1	HSPA1-2_6-8-like_NBD	3..379	CDD:212675	204/381 (54%)
Hspa9	NP_034611.2	Interaction with NFS1. /evidence=ECO:0000250\|UniProtKB:P38646	1..432		207/388 (53%)
		dnaK	52..673	CDD:234715	310/629 (49%)
		HSPA9-like_NBD	52..428	CDD:212683	204/380 (54%)
		Interaction with FXN and ISCU. /evidence=ECO:0000250\|UniProtKB:P38646	432..679		103/240 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	656..679		3/15 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D288077at2759
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820