DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsp68 and Hspa2

DIOPT Version :9

Sequence 1:	NP_524474.1	Gene:	Hsp68 / 42852	FlyBaseID:	FBgn0001230	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_001002012.1	Gene:	Hspa2 / 15512	MGIID:	96243	Length:	633	Species:	Mus musculus

Alignment Length:	638	Identity:	455/638 - (71%)
Similarity:	544/638 - (85%)	Gaps:	14/638 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PAIGIDLGTTYSCVGVFQYGKVEIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPKNSVFD 66
            ||||||||||||||||||:|||||||||||||||||||||||:||||||||||||||||.|::||
Mouse     6 PAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTIFD 70

  Fly    67 AKRLIGRRFDDSKIQEDIKHWPFKVINDNGKPKISVEFKGANKCFSPEEISSMVLTKMKETAEAY 131
            |||||||:|:|:.:|.|:|||||:|:::.||||:.||:||..|.|.||||||||||||||.||||
Mouse    71 AKRLIGRKFEDATVQSDMKHWPFRVVSEGGKPKVQVEYKGEMKTFFPEEISSMVLTKMKEIAEAY 135

  Fly   132 LGTTVKDAVITVPAYFNDSQRQATKDAGAIAGINVLRIINEPTAAALAYGLDKN--LKGERNVLI 194
            ||..|:.|||||||||||||||||||||.|.|:|||||||||||||:||||||.  ..||:||||
Mouse   136 LGGKVQSAVITVPAYFNDSQRQATKDAGTITGLNVLRIINEPTAAAIAYGLDKKGCAGGEKNVLI 200

  Fly   195 FDLGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVNHFAEEFKRKYKKDLRSNPRALR 259
            |||||||||||||||::| :|||:||||||||||||||||:|:|.|||||||:|||:..|.||:|
Mouse   201 FDLGGGTFDVSILTIEDG-IFEVKSTAGDTHLGGEDFDNRMVSHLAEEFKRKHKKDIGPNKRAVR 264

  Fly   260 RLRTAAERAKRTLSSSTEASLEIDALYEGHDFYSKVSRARFEELCGDLFRNTLEPVEKALKDAKM 324
            |||||.|||||||||||:||:|||:||||.|||:.::|||||||..||||.|||||||||:|||:
Mouse   265 RLRTACERAKRTLSSSTQASIEIDSLYEGVDFYTSITRARFEELNADLFRGTLEPVEKALRDAKL 329

  Fly   325 DKSQIHDIVLVGGSTRIPKVQNLLQNFFGGKTLNLSINPDEAVAYGAAIQAAILSGDKSSEIKDV 389
            ||.||.:||||||||||||:|.|||:||.||.||.|||||||||||||:|||||.||||..::|:
Mouse   330 DKGQIQEIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILIGDKSENVQDL 394

  Fly   390 LLVDVAPLSLGIETAGGVMTKLIERNSRIPCKQSKTFTTYADNQPAVTIQVFEGERALTKDNNVL 454
            ||:||.||||||||||||||.||:||:.||.||::|||||:|||.:|.:||:|||||:|||||:|
Mouse   395 LLLDVTPLSLGIETAGGVMTPLIKRNTTIPTKQTQTFTTYSDNQSSVLVQVYEGERAMTKDNNLL 459

  Fly   455 GTFDLTGVPPAPRGVPKIDVTFDLDANGILNVTAKEQGTGNAKNITIKNDKGRLSQADIDRMLSE 519
            |.|||||:||||||||:|:||||:||||||||||.::.||....|||.|||||||:.|||||:.|
Mouse   460 GKFDLTGIPPAPRGVPQIEVTFDIDANGILNVTAADKSTGKENKITITNDKGRLSKDDIDRMVQE 524

  Fly   520 AEKYAEEDERHRQRIAARNQLETYLFGVKEAAENG--GDRISAADKSSIVERCSEAMKWLDSNTT 582
            ||:|..|||.:|.|:||:|.:|:|.:.:|:..|:.  ..:||..||:.|:::|.|.:.|||.|..
Mouse   525 AERYKSEDEANRDRVAAKNAVESYTYNIKQTVEDEKLRGKISEQDKNKILDKCQEVINWLDRNQM 589

  Fly   583 AEKEEYEYKLKELEQFCSPIMTKMHKGGGDGQQAPNFGQQAGGYKGPTVEEVD 635
            |||:|||:|.||||:.|:||::|:::||      |..|..:|   |||:||||
Mouse   590 AEKDEYEHKQKELERVCNPIISKLYQGG------PGGGGSSG---GPTIEEVD 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp68	NP_524474.1	PTZ00009	2..635	CDD:240227	453/636 (71%)
Hsp68	NP_524474.1	HSPA1-2_6-8-like_NBD	3..379	CDD:212675	300/377 (80%)
Hspa2	NP_001002012.1	PTZ00009	2..615	CDD:240227	443/609 (73%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250\|UniProtKB:P11142	2..389		305/383 (80%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250\|UniProtKB:P11142	397..512		83/114 (73%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	613..633		10/28 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53894
OrthoDB	1	1.010	-	-		D180577at33208
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.730