DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsp68 and Hyou1

DIOPT Version :9

Sequence 1:	NP_524474.1	Gene:	Hsp68 / 42852	FlyBaseID:	FBgn0001230	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_067370.3	Gene:	Hyou1 / 12282	MGIID:	108030	Length:	999	Species:	Mus musculus

Alignment Length:	683	Identity:	207/683 - (30%)
Similarity:	326/683 - (47%)	Gaps:	101/683 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPAIGIDLGTTYSCVGVFQYG-KVEIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPKNSV 64
            :..:.:|||:....|.:.:.| .:||:.|.:..|.||..|...::||.:||:|......|||.::
Mouse    33 LAVMSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPVTVTLKENERFLGDSAAGMAIKNPKATL 97

  Fly    65 FDAKRLIGRRFDDSKIQEDIKHWP-FKVINDNGKPKISVEFKGANKCFSPEEISSMVLTKMKETA 128
            ...:.|:|::.|:..:......:| .::|.|..:..:..:.....: |||||:..|||...:..|
Mouse    98 RYFQHLLGKQADNPHVALYRSRFPEHELIVDPQRQTVRFQISPQLQ-FSPEEVLGMVLNYSRSLA 161

  Fly   129 EAYLGTTVKDAVITVPAYFNDSQRQATKDAGAIAGINVLRIINEPTAAALAYGL----DKNLKGE 189
            |.:....:|||||||||:||.::|:|...|..:||:.||::||:.||.||:||:    |.|...:
Mouse   162 EDFAEQPIKDAVITVPAFFNQAERRAVLQAARMAGLKVLQLINDNTATALSYGVFRRKDINSTAQ 226

  Fly   190 RNVLIFDLGGGTFDVSILTID-----EGSL---FEVRSTAGDTHLGGEDFDNRLVNHFAEEFKRK 246
             ||:.:|:|.|:...:|:|..     |..:   .::|....|..|||.:.:.||..|.|:.|..:
Mouse   227 -NVMFYDMGSGSTVCTIVTYQTVKTKEAGMQPQLQIRGVGFDRTLGGLEMELRLREHLAKLFNEQ 290

  Fly   247 YK----KDLRSNPRALRRLRTAAERAKRTLSSSTEASLEIDALYEGHDFYSKVSRARFEELCGDL 307
            .|    ||:|.||||:.:|...|.|.|..||::.:...:|:.|.:..||.:||:|..|||||.||
Mouse   291 RKGQKAKDVRENPRAMAKLLREANRLKTVLSANADHMAQIEGLMDDVDFKAKVTRVEFEELCADL 355

  Fly   308 FRNTLEPVEKALKDAKMDKSQIHDIVLVGGSTRIPKVQNLLQNFFGGKTLNLSINPDEAVAYGAA 372
            |.....||::||:.|:|...||..::||||:||:||||.:|....|.:.|..:||.|||.|.||.
Mouse   356 FDRVPGPVQQALQSAEMSLDQIEQVILVGGATRVPKVQEVLLKAVGKEELGKNINADEAAAMGAV 420

  Fly   373 IQAAILSGDKSSEIKDVLLVD--VAPL----SLGIETAGGVMTKLIERNSRI------PCKQSK- 424
            .|||.||  |:.::|..::.|  :.|:    :..:|...|:  :.::.|.|:      |..|.|
Mouse   421 YQAAALS--KAFKVKPFVVRDAVIYPILVEFTREVEEEPGL--RSLKHNKRVLFSRMGPYPQRKV 481

  Fly   425 -TFTTYADNQPAVTIQVFEGERAL--TKDNNVLGTFDLT-----GVPPAPRGVPK-----IDVTF 476
             ||..|:.:   ....:..|:...  .:|..|.|:.:||     ||..:.:..|.     |...|
Mouse   482 ITFNRYSHD---FNFHINYGDLGFLGPEDLRVFGSQNLTTVKLKGVGESFKKYPDYESKGIKAHF 543

  Fly   477 DLDANGILNVTAKEQGTGNAKNITIKNDKGRLSQADIDRMLSEAEKYAEEDERHRQRIAARNQLE 541
            :||.:|:|:                           :||:.|..|...|:.......:.......
Mouse   544 NLDESGVLS---------------------------LDRVESVFETLVEDSPEEESTLTKLGNTI 581

  Fly   542 TYLFG---VKEAAENGGDRISAADKSSIVERCSEAMKWLDSNTTAEKEEYEYKLKELEQFCSPIM 603
            :.|||   ..:|.|||.|.:...::|.     :|..|...:.....|||.|...:|..| ..|..
Mouse   582 SSLFGGGTSSDAKENGTDAVQEEEESP-----AEGSKDEPAEQGELKEEAEPPAEETSQ-PPPSE 640

  Fly   604 TK----------MHKGGGDGQQA--PNFGQQAG 624
            .|          ..|..||..:|  ||...|||
Mouse   641 PKGDAAREGEKPDEKESGDKPEAQKPNEKGQAG 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp68	NP_524474.1	PTZ00009	2..635	CDD:240227	207/682 (30%)
Hsp68	NP_524474.1	HSPA1-2_6-8-like_NBD	3..379	CDD:212675	143/393 (36%)
Hyou1	NP_067370.3	HYOU1-like_NBD	36..424	CDD:212672	141/389 (36%)
		MDN1	<554..767	CDD:227596	33/126 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	567..694		28/113 (25%)
		PHA03169	<586..>691	CDD:223003	26/94 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	909..999
		Prevents secretion from ER. /evidence=ECO:0000255	996..999
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810