DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp68 and HSPH1

DIOPT Version :9

Sequence 1:	NP_524474.1	Gene:	Hsp68 / 42852	FlyBaseID:	FBgn0001230	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_001273433.1	Gene:	HSPH1 / 10808	HGNCID:	16969	Length:	860	Species:	Homo sapiens

Alignment Length:	820	Identity:	218/820 - (26%)
Similarity:	344/820 - (41%)	Gaps:	253/820 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SYVAFTDSERLIGDAAKNQVAMNPKNSVFDAKRLIGRRFDDSKIQEDIKHWPFKVIN-DNGKPKI 100
            |.::|....|.||.|||||...:..|:|.:.||..||.|:|..||::.::..:.::. .||...|
Human    39 SVISFGSKNRTIGVAAKNQQITHANNTVSNFKRFHGRAFNDPFIQKEKENLSYDLVPLKNGGVGI 103

  Fly   101 SVEFKGANKCFSPEEISSMVLTKMKETAEAYLGTTVKDAVITVPAYFNDSQRQATKDAGAIAGIN 165
            .|.:.|....||.|:|::|:|||:|||||..|...|.|.||:||::|.|::|::..||..|.|:|
Human   104 KVMYMGEEHLFSVEQITAMLLTKLKETAENSLKKPVTDCVISVPSFFTDAERRSVLDAAQIVGLN 168

  Fly   166 VLRIINEPTAAALAYGLDK----NLKGERNVLIF-DLGGGTFDVSILTIDEGSLFEVRSTAGDTH 225
            .||::|:.||.||.||:.|    :|..:..:::| |:|...|.||....::|.| :|..||.|..
Human   169 CLRLMNDMTAVALNYGIYKQDLPSLDEKPRIVVFVDMGHSAFQVSACAFNKGKL-KVLGTAFDPF 232

  Fly   226 LGGEDFDNRLVNHFAEEFKRKYKKDLRSNPRALRRLRTAAERAKRTLSS-STEASLEIDALYEGH 289
            |||::||.:||.||..|||.|||.|.:|..|||.||....|:.|:.:|| ||:..|.|:......
Human   233 LGGKNFDEKLVEHFCAEFKTKYKLDAKSKIRALLRLYQECEKLKKLMSSNSTDLPLNIECFMNDK 297

  Fly   290 DFYSKVSRARFEELCGDLFRNTLEPVEKALKDAKMDKSQIHDIVLVGGSTRIPKVQNLLQNFFGG 354
            |...|::|::|||||.:|.:....|:...|:...:....:..:.:|||:||||.|:..:..|| |
Human   298 DVSGKMNRSQFEELCAELLQKIEVPLYSLLEQTHLKVEDVSAVEIVGGATRIPAVKERIAKFF-G 361

  Fly   355 KTLNLSINPDEAVAYGAAIQAAILSGDKSSEIKDVLLVDVAPLSLGI-------ETAGGVMTKLI 412
            |.::.::|.|||||.|.|:|.||||  .:.::::..:.|..|..:.:       :|.|  :.::.
Human   362 KDISTTLNADEAVARGCALQCAILS--PAFKVREFSVTDAVPFPISLIWNHDSEDTEG--VHEVF 422

  Fly   413 ERNSRIPCKQSKTF---------TTYADNQ----PAVTIQVF---------EGERALTK------ 449
            .||...|..:..||         ..|:|.|    |...|..|         :||::..|
Human   423 SRNHAAPFSKVLTFLRRGPFELEAFYSDPQGVPYPEAKIGRFVVQNVSAQKDGEKSRVKVKVRVN 487

  Fly   450 ------------------------------------------------DNNVLGT--------FD 458
                                                            ||:..||        ..
Human   488 THGIFTISTASMVEKVPTEENEMSSEADMECLNQRPPENPDTDKNVQQDNSEAGTQPQVQTDAQQ 552

  Fly   459 LTGVPPAPR-------------------------GVPKI---DVTFDLDAN-------GILNVTA 488
            .:..||:|.                         ..|||   :|...::||       .:||:..
Human   553 TSQSPPSPELTSEENKIPDADKANEKKVDQPPEAKKPKIKVVNVELPIEANLVWQLGKDLLNMYI 617

  Fly   489 KEQG-----------TGNAKN--------------------------------ITIKND------ 504
            :.:|           ..:|||                                :|...|
Human   618 ETEGKMIMQDKLEKERNDAKNAVEEYVYEFRDKLCGPYEKFICEQDHQNFLRLLTETEDWLYEEG 682

  Fly   505 KGRLSQADIDRMLSEAEK--------YAEEDER------------HRQRIAA--RNQLETYLFGV 547
            :.:..||.:|: |.|..|        :.|.:||            |..:|||  ||:.|.|
Human   683 EDQAKQAYVDK-LEELMKIGTPVKVRFQEAEERPKMFEELGQRLQHYAKIAADFRNKDEKY---- 742

  Fly   548 KEAAENGGDRISAADKSSIVERCSEAMKWLDS--NTTAEK----------EEYEYKLKELEQFCS 600
                    :.|..::...:.:..:|.|:|:::  |..|:|          :|.:.|:|||...|.
Human   743 --------NHIDESEMKKVEKSVNEVMEWMNNVMNAQAKKSLDQDPVVRAQEIKTKIKELNNTCE 799

  Fly   601 PIMTK------------------MHKGGGDGQQAPNFGQQ 622
            |::|:                  :.|...|.:...|||.:
Human   800 PVVTQPKPKIESPKLERTPNGPNIDKKEEDLEDKNNFGAE 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp68	NP_524474.1	PTZ00009	2..635	CDD:240227	218/820 (27%)
Hsp68	NP_524474.1	HSPA1-2_6-8-like_NBD	3..379	CDD:212675	140/348 (40%)
HSPH1	NP_001273433.1	NBD_sugar-kinase_HSP70_actin	39..386	CDD:327376	140/348 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810