Protein Alignment Atg6 and BECN2

DIOPT Version :9

• Sequence 1: NP_651209.1
• Gene: Atg6 / 42850
• FlyBaseID: FBgn0264325
• Length: 422
• Species: Drosophila melanogaster
• Sequence 2: NP_001277622.1
• Gene: BECN2 / 441925
• HGNCID: 38606
• Length: 431
• Species: Homo sapiens
• Alignment Length: 442
• Identity: 171/442 - (38%)
• Similarity: 244/442 - (55%)
• Gaps: 45/442 - (10%)

  Fly     8 AVSFACQRCLQPIVLDEQLEKISVHAMAELSLPIYG--DNGNTLDP-------------QDASSF 57
            ::.|.||||.|.:.|....|..|:.|   ...|..|  :.|:|.:|             ||.:|.
Human     3 SIRFLCQRCHQALKLSGSSESRSLPA---APAPTSGQAEPGDTREPGVTTREVTDAEEQQDGASS 64

  Fly    58 DHFVPPYRLTDSINGTGFMLVSDGRDN-----------KKMSAAFKLKAELFDCLSSNSEIDHPL 111
            ..  ||        |.|  .||.|..|           ..:|:..|...::||.:|..:.:||||
Human    65 RS--PP--------GDG--SVSKGHANIFTLLGELGAMHMLSSIQKAAGDIFDIVSGQAVVDHPL 117

  Fly   112 CEECADSMLEIMDRELRIAEDEWDVYKAYLDELEQQRVAPNVEALDKELDELKRSEQQLLSELKE 176
            ||||.||:||.:|.:|.:.|.:...|:..|:..|.........||..||.:|:..|.:|:.||::
Human   118 CEECTDSLLEQLDIQLALTEADSQNYQRCLETGELATSEDEAAALRAELRDLELEEARLVQELED 182

  Fly   177 LKKEEQSLNDAIAEEEQEREELHEQEESYWREYTKHRRELMLTEDDKRSLECQIAYSKQQLDKLR 241
            :.:........:...:.|..||.:||..::|:|:..:|:.:...|...::|.|:.|::.|.|:|:
Human   183 VDRNNARAAADLQAAQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYARVQRDRLK 247

  Fly   242 DTNIFNITFHIWHAGHFGTINNFRLGRLPSVSVDWSEINAAWGQTVLLLSALARKIGLTFERYRV 306
            :.|.|..||.||..|..|.||||||||||:|.|.|:|||.||||..|||..||..|||.|:|||:
Human   248 EINCFTATFEIWVEGPLGVINNFRLGRLPTVRVGWNEINTAWGQAALLLLTLANTIGLQFQRYRL 312

  Fly   307 VPFGNHSYVEVLGENR-ELPLYGSGGFKFFWDTKFDAAMVAFLDCLTQFQKEVEKRDTEFLLPY- 369
            :|.|||||::.|.::| ||||:..||...|.:.|:|.||||||||:.||::|.||.:....|||
Human   313 IPCGNHSYLKSLTDDRTELPLFCYGGQDVFLNNKYDRAMVAFLDCMQQFKEEAEKGELGLSLPYG 377

  Fly   370 -KMEKGKIID-PSTGNSYSIKIQFNSEEQWTKALKFMLTNLKWGLAWVSSQF 419
             ::|.|.:.| ...|..|||:...|::|.|||||||||.|.||.|.||:|::
Human   378 IQVETGLMEDVGGRGECYSIRTHLNTQELWTKALKFMLINFKWSLIWVASRY 429

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atg6	NP_651209.1	APG6	110..418	CDD:282029	137/311 (44%)
BECN2	NP_001277622.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	17..74		16/71 (23%)
		APG6	116..428	CDD:282029	137/311 (44%)
		Required for homodimer formation. /evidence=ECO:0000269|PubMed:28218432	173..243		16/69 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146153
Domainoid	1	1.000	91	1.000	Domainoid score	I7689
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	425	1.000	Inparanoid score	I1764
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1085752at2759
OrthoFinder	1	1.000	-	-		FOG0002528
OrthoInspector	1	1.000	-	-		otm41282
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12768
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1898
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	9.000