DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atg6 and atg6

DIOPT Version :9

Sequence 1:	NP_651209.1	Gene:	Atg6 / 42850	FlyBaseID:	FBgn0264325	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_001342824.1	Gene:	atg6 / 3361548	PomBaseID:	SPAC20G8.10c	Length:	464	Species:	Schizosaccharomyces pombe

Alignment Length:	473	Identity:	152/473 - (32%)
Similarity:	241/473 - (50%)	Gaps:	78/473 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VSFACQRCLQPI----VLDEQLEKIS-------VHAMAELSLPIYGDNGNTLDPQDASS------ 56
            :.:.||||...|    |.|:.|.|:.       |.|.   ||....::|.:.|..::||
pombe     1 MQYLCQRCHSLINFKDVYDDDLLKLKNLPKSRFVQAS---SLTEMNESGESDDQMNSSSEDYPAQ 62

  Fly    57 ---------------FDHFVPPYRLTDSINGTGFMLV---SDGRDNKKMSA-----AFKLKAE-- 96
                           ||:..||...|.:::  .|:::   .||.:.:|.|.     .|..|.|
pombe    63 RLQLYKKTISEGDYNFDNVPPPELRTPTLD--SFVVLPAAKDGYEEEKNSPEEVNDLFSWKIEIY 125

  Fly    97 --LFDCLSSNSEIDHPLCEECADSMLEIMDRELRIAEDEWDVYKAYLDELEQQRV-APNVEALDK 158
              :||.|||.:::|||||.|||:.:.|.|.:.||..::|..:|..|.:.|..|.| ..|..|||.
pombe   126 NRIFDLLSSKTKVDHPLCVECAELLTEEMSKTLRALKEEKKMYFNYDNFLSSQTVHEENTAALDS 190

  Fly   159 ELDELKRSEQQLLSELKELKKEEQSLNDAIAEEEQEREELHEQEESYWREYTKHR-RELMLTEDD 222
            |:|||.:...:...:::|:..|...|...:.|.::|:|:::.:|:.::....:.: ::|.|
pombe   191 EIDELMKQINEKEEKIEEISDETDKLQKLLRELDEEKEKVYAEEQEFYNNLNQFQIKKLSL---- 251

  Fly   223 KRSLEC---QIAYSKQQLDKLRDTNIFNITFHIWH------AGHFGTINNFRLGRLPSVSVDWSE 278
            :|..:|   :..::.::|:||:..|:|:..|:|.|      .|...|||..|||||||..|:|:|
pombe   252 ERQYDCANLEFEHNSRKLEKLQKMNVFSDIFYISHYSEPNGEGSIATINGLRLGRLPSQKVNWAE 316

  Fly   279 INAAWGQTVLLLSALARKIGLTFERYRVVPFGNHSYVEVLGEN--------RELPLYGSGGFKFF 335
            ||||||.|||||..|..|:......|::.|||:.|::.....:        .:|.|:.||..|.|
pombe   317 INAAWGMTVLLLDVLTEKLDFHSSSYQLKPFGSQSFIIRFDRDPNGNQVKPTKLDLFSSGELKIF 381

  Fly   336 WDTKFDAAMVAFLDCLTQFQKEVEKRDTEFLLPYKMEKGKIIDPSTGNSYSIKIQFNSEEQWTKA 400
            .:.:||..||||||.|.||......:....:|||.:|..:|      ....|::.||.:|.||:|
pombe   382 MNRRFDQGMVAFLDYLHQFGDFCAAKTPSAVLPYAIENDRI------GGKCIRLAFNQDENWTRA 440

  Fly   401 LKFMLTNLKWGLAWVSSQ 418
            |||:||::|:..|:||||
pombe   441 LKFVLTDIKFLEAYVSSQ 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg6	NP_651209.1	APG6	110..418	CDD:282029	113/326 (35%)
atg6	NP_001342824.1	APG6	141..457	CDD:309295	112/325 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	133	1.000	Domainoid score	I1299
eggNOG	1	0.900	-	-		E1_KOG2751
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2794
Inparanoid	1	1.050	215	1.000	Inparanoid score	I929
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002528
OrthoInspector	1	1.000	-	-		oto101209
orthoMCL	1	0.900	-	-		OOG6_102610
Panther	1	1.100	-	-	LDO	PTHR12768
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1774
SonicParanoid	1	1.000	-	-		X1898
TreeFam	1	0.960	-	-
	13	12.850