Protein Alignment Atg6 and Becn2

DIOPT Version :9

• Sequence 1: NP_651209.1
• Gene: Atg6 / 42850
• FlyBaseID: FBgn0264325
• Length: 422
• Species: Drosophila melanogaster
• Sequence 2: NP_001277621.1
• Gene: Becn2 / 226720
• MGIID: 2684950
• Length: 447
• Species: Mus musculus
• Alignment Length: 444
• Identity: 164/444 - (36%)
• Similarity: 241/444 - (54%)
• Gaps: 43/444 - (9%)

  Fly    11 FACQRCLQPIVLDEQ----LEKISVHAMAELSLPI------------YGDNGNTLDPQDASSFDH 59
            |.||||.:|:.|.:|    || :..||.....:|:            :.|.|.........:|.
Mouse     6 FLCQRCKEPLKLLQQQGGPLE-VQHHANTPTEIPVSAESQVRTSGRPHSDGGRVSQGSALCTFT- 68

  Fly    60 FVPPYRLT----DSINGT--------GFMLVSDGRDNKKMSAAFKLKAELFDCLSSNSEIDHPLC 112
                 .||    ||..||        .|.|:.:....:.|:.......|.|:.||....:|||||
Mouse    69 -----LLTSGGPDSEGGTTSQGNACCTFTLLGESASMRTMNTIQNTVLETFEILSDQKVVDHPLC 128

  Fly   113 EECADSMLEIMDRELRIAEDEWDVYKAYLD-EL---EQQRVAPNVEALDKELDELKRSEQQLLSE 173
            .:|.|.:|..:|.:|.:...:...||::.| ||   |::|.|.:.| |..||..|::.|.:|..|
Mouse   129 VDCTDHLLMQLDDQLALLASDNQKYKSFQDRELLVSEEEREALHAE-LCAELSSLEQEEARLTQE 192

  Fly   174 LKELKKEEQSLNDAIAEEEQEREELHEQEESYWREYTKHRRELMLTEDDKRSLECQIAYSKQQLD 238
            |::|......:...:...:.|.:||::|.|.:..||:..:.|.:...|...|:|.|:.|:..|..
Mouse   193 LEDLDGHHARVAAELRAAQAESKELYKQHEQHRVEYSVFKMEQLELMDQLSSVENQLTYALSQQY 257

  Fly   239 KLRDTNIFNITFHIWHAGHFGTINNFRLGRLPSVSVDWSEINAAWGQTVLLLSALARKIGLTFER 303
            :||.|||||.||.|...|..|.|||||||.||.|.|.|:||::|||||||||.:|::..||.|:|
Mouse   258 RLRQTNIFNATFTISDEGPLGVINNFRLGCLPGVRVGWTEISSAWGQTVLLLFSLSKIAGLQFQR 322

  Fly   304 YRVVPFGNHSYVEVLGENRELPLYGSGGFKFFWDTKFDAAMVAFLDCLTQFQKEVEKRDTEFLLP 368
            |::||||:|||::.|..:..|||:..|....|.:.|||..|.||||||.||.:|:|:.:....||
Mouse   323 YQLVPFGDHSYLKSLTGDGVLPLFSDGSHSVFLNNKFDCGMKAFLDCLQQFVEEIERDERCPCLP 387

  Fly   369 YK--MEKGKIIDP-STGNSYSIKIQFNSEEQWTKALKFMLTNLKWGLAWVSSQF 419
            |:  :::|.:.|. .:|...||:...|:||:|::||||||::||..|||.|.:|
Mouse   388 YRIHVKEGLMEDVWDSGECCSIRTHLNTEEEWSRALKFMLSDLKLILAWASLRF 441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atg6	NP_651209.1	APG6	110..418	CDD:282029	132/314 (42%)
Becn2	NP_001277621.1	APG6	126..440	CDD:282029	132/314 (42%)
		APP_E2	<151..>220	CDD:289677	21/69 (30%)
		Required for homodimer formation. /evidence=ECO:0000250|UniProtKB:A8MW95	186..256		18/69 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836255
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002528
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12768
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1898
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.940