DRSC/TRiP Functional Genomics Resources

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Protein Alignment Atg6 and Becn1

DIOPT Version :9

Sequence 1:NP_651209.1 Gene:Atg6 / 42850 FlyBaseID:FBgn0264325 Length:422 Species:Drosophila melanogaster
Sequence 2:NP_001029289.1 Gene:Becn1 / 114558 RGDID:620190 Length:448 Species:Rattus norvegicus


Alignment Length:438 Identity:218/438 - (49%)
Similarity:300/438 - (68%) Gaps:32/438 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 VSFACQRCLQPIVLDEQLEKISVHAMAELSLPIY-------GDNGNTLDPQDASSFD-------- 58
            |||.||||.||:.||...:.:....:.||:.|:.       |::    ..::|:|.:        
  Rat    13 VSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGES----QEEEANSGEEPFIETRQ 73

  Fly    59 -----HFVPPYRLTDSINGTGFMLV---SDGRDNKKMSAAFKLKAELFDCLSSNSEIDHPLCEEC 115
                 .|:||.|:..:.:...|.|:   |||...:.:|...|:..:|||.:|..:::||||||||
  Rat    74 DGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTGDLFDIMSGQTDVDHPLCEEC 138

  Fly   116 ADSMLEIMDRELRIAEDEWDVYKAYLDELEQQRVAPNVEALDKELDELKRSEQQLLSELKELKKE 180
            .|::|:.:|.:|.:.|:|...||..|:.|||.....: |.|.:||.||...|::|:.||::::|.
  Rat   139 TDTLLDQLDTQLNVTENECQNYKRCLEMLEQMNEGDS-EQLQRELKELALEEERLIQELEDVEKN 202

  Fly   181 EQSLNDAIAEEEQEREELHEQEESYWREYTKHRRELMLTEDDKRSLECQIAYSKQQLDKLRDTNI 245
            .:.:.:.:.:.:.|.|.|.::|..|.|||::.:|:.:..:|:.:|:|.|:.|::.|||||:.||:
  Rat   203 RKVVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQLELDDELKSVENQMRYAQMQLDKLKKTNV 267

  Fly   246 FNITFHIWHAGHFGTINNFRLGRLPSVSVDWSEINAAWGQTVLLLSALARKIGLTFERYRVVPFG 310
            ||.||||||:|.||||||||||||||..|:|:|||||||||||||.|||.|:||.|:|||:||:|
  Rat   268 FNATFHIWHSGQFGTINNFRLGRLPSAPVEWNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYG 332

  Fly   311 NHSYVEVL-GENRELPLYGSGGFKFFWDTKFDAAMVAFLDCLTQFQKEVEKRDTEFLLPYKM--E 372
            ||||:|.| .:::|||||.|||.:||||.|||.||||||||:.||::||||.:|.|.|||:|  |
  Rat   333 NHSYLESLTDKSKELPLYCSGGLRFFWDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPYRMDVE 397

  Fly   373 KGKIIDP-STGNSYSIKIQFNSEEQWTKALKFMLTNLKWGLAWVSSQF 419
            ||||.|. .:|.|||||.||||||||||||||||||||||||||||||
  Rat   398 KGKIEDTGGSGGSYSIKTQFNSEEQWTKALKFMLTNLKWGLAWVSSQF 445

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Atg6NP_651209.1 APG6 110..418 CDD:282029 181/311 (58%)
Becn1NP_001029289.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 47..72 3/28 (11%)
BH3 105..127 CDD:291932 6/21 (29%)
BH3. /evidence=ECO:0000250 106..125 5/18 (28%)
Interaction with BCL2 and BCL2L1 isoform Bcl-X(L). /evidence=ECO:0000250|UniProtKB:Q14457 110..157 19/46 (41%)
APG6 133..444 CDD:282029 181/311 (58%)
MT 194..>267 CDD:289543 23/72 (32%)
Evolutionary conserved domain (ECD). /evidence=ECO:0000250|UniProtKB:Q14457 243..448 146/203 (72%)
Required for membrane-association. /evidence=ECO:0000250|UniProtKB:Q14457 423..448 23/23 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166339919
Domainoid 1 1.000 279 1.000 Domainoid score I1629
eggNOG 1 0.900 - - E1_KOG2751
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H2794
Inparanoid 1 1.050 425 1.000 Inparanoid score I1706
OMA 1 1.010 - - QHG49029
OrthoDB 1 1.010 - - D1085752at2759
OrthoFinder 1 1.000 - - FOG0002528
OrthoInspector 1 1.000 - - oto97011
orthoMCL 1 0.900 - - OOG6_102610
Panther 1 1.100 - - LDO PTHR12768
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X1898
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1615.770

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